基因页：ATP2B2

概括?
基因ID 491
Symbol ATP2B2
同义词 PMCA2|PMCA2a|PMCA2i
描述 ATPase质膜Ca2+运输2
参考 MIM：108733|HGNC：HGNC：815|Ensembl:ENSG00000157087|HPRD:00160|Vega:OTTHUMG00000128679
基因type protein-coding
地图位置 3p25.3
Pascal P值 9.295E-5
Fetal beta -2.141
支持 ION BALANCE
G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-CONSESUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_Synaptosome
G2Cdb.humanPSD
G2Cdb.humanPSP
COMPOSITESET
Darnell FMRP targets

数据源中的基因
基因set name 基因组方法 描述 Info
CV：GWASDB 全基因组关联研究 gwasdbrecords for schizophrenia
简历：PGCNP Genome-wide Association Study GWAS
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 高通量文献搜索 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

第一节遗传学和表观遗传学注释

@DNM table

基因 Chromosome Position Ref Alt Transcript AA change 突变类型 Sift CG46 Trait Study
ATP2B2 chr3 10491069 G A NM_001001331
NM_001683		 .
.		 silent
silent		 精神分裂症 DNM：Fromer_2014


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 核苷酸结合 IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005509 钙离子结合 IEA -
GO:0005516 calmodulin binding IEA -
GO:0005524 ATP结合 IEA -
GO:0005388 calcium-transporting ATPase activity NAS 1313367
GO:0016787 hydrolase activity IEA -
GO：0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0030182 neuron differentiation IDA neuron (GO term level: 8) 11259493
去：0008152 metabolic process IEA -
GO:0007605 sensory perception of sound 小鬼 15829536
GO:0006816 calcium ion transport IEA -
GO:0006812 cation transport IEA -
细胞分量 GO term Evidence Neuro keywords PubMed ID
GO:0005737 细胞质 IDA 15765049
GO:0016021 integral to membrane IEA -
GO:0005886 质膜 NAS 1313367

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 该途径中的所有SZGR 2.0基因
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 该途径中的所有SZGR 2.0基因
Reactome血小板稳态 78 49 该途径中的所有SZGR 2.0基因
REACTOME PLATELET CALCIUM HOMEOSTASIS 18 10 该途径中的所有SZGR 2.0基因
REACTOME ION TRANSPORT BY P TYPE ATPASES 34 21 该途径中的所有SZGR 2.0基因
REACTOME ION CHANNEL TRANSPORT 55 42 该途径中的所有SZGR 2.0基因
REACTOME HEMOSTASIS 466 331 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 该途径中的所有SZGR 2.0基因
周的炎症反应fima 544 308 该途径中的所有SZGR 2.0基因
周炎性反应lps up 431 237 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
Jazag TGFB1信号传导DN 35 24 该途径中的所有SZGR 2.0基因
KIM MYC AMPLIFICATION TARGETS UP 201 127 该途径中的所有SZGR 2.0基因
LEE TARGETS OF PTCH1 AND SUFU DN 83 69 该途径中的所有SZGR 2.0基因
CERVERA SDHB TARGETS 2 114 76 该途径中的所有SZGR 2.0基因
URS ADIPOCYTE DIFFERENTIATION UP 74 51 该途径中的所有SZGR 2.0基因
lu衰老的脑dn 153 120 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
kayo卡路里限制肌肉 95 64 该途径中的所有SZGR 2.0基因
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN 60 45 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K27ME3 79 59 该途径中的所有SZGR 2.0基因
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 该途径中的所有SZGR 2.0基因
具有H3K4ME2和H3K27ME3的Meissner NPC HCP 349 234 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
HOSHIDA LIVER CANCER SUBCLASS S2 115 74 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 该途径中的所有SZGR 2.0基因
Browne HCMV感染1小时 61 44 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS UP 745 475 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family 目标位置 mirna id miRNA seq
UTR start UTR end Match method
miR-101 1494 1500 1A HSA-MIR-101 UACAGUACUGUGAUAACUGAAG
mir-127 1410 1416 1A hsa-miR-127脑 ucggauccgugugagcuuggcu
miR-130/301 2597 2603 m8 HSA-MIR-130A脑 CAGUGCAAUGUUAAAAGGGCAU
HSA-MIR-301 CAGUGCAAUAGUAUUGUCAAAGC
HSA-MIR-130b脑 CAGUGCAAUGAUGAAAGGGCAU
HSA-MIR-454-3P uagugcaauauugcuuauaggguuu
HSA-MIR-130A脑 CAGUGCAAUGUUAAAAGGGCAU
HSA-MIR-301 CAGUGCAAUAGUAUUGUCAAAGC
HSA-MIR-130b脑 CAGUGCAAUGAUGAAAGGGCAU
HSA-MIR-454-3P uagugcaauauugcuuauaggguuu
mir-135 1536年 1542 m8 hsa-miR-135a Uauggcuuuuuuuuccuauga
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135a Uauggcuuuuuuuuccuauga
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
mir-139 1495 1501 m8 hsa-miR-139脑 UCUACAGUGCACGUGUCU
hsa-miR-139脑 UCUACAGUGCACGUGUCU
mir-144 1493 1500 1A,m8 hsa-miR-144 uacaguauagauguauguaguag
mir-15/16/195/424/497 1355 1361 m8 hsa-miR-15a脑 UAGCAGCACAUAAUGGUUUGUG
HSA-MIR-16脑 uagcagcacguaaauauuggcg
hsa-miR-15b脑 uagcagcacaucaugguuaca
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
HSA-MIR-424 Cagcagcaauucauguuuugaa
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
mir-17-5p/20/93.mr/106/519.D 1663年 1669年 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
HSA-MIR-20A脑 uaaagugcuuauagugcagguag
HSA-MIR-106A aaaagugcuuacugugcagguagc
HSA-MIR-106BSZ uaaagugcugacagugcagau
HSA-MIR-20BSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
mir-181 326 333 1A,m8 hsa-miR-181a脑 aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c脑 aacauucaaccugucggugagu
hsa-miR-181d脑 AACAUUCAUUGUUGUCGGUGGGUU
hsa-miR-181a脑 aacauucaacgcugucggugagu
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181c脑 aacauucaaccugucggugagu
hsa-miR-181d脑 AACAUUCAUUGUUGUCGGUGGGUU
mir-19 559 565 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
mir-191 955 961 m8 hsa-miR-191脑 CAACGGAAUCCCAAAAGCAGCU
mir-199 848 854 m8 hsa-miR-199a cccaguucagacuaccuguuc
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-203.1 1182 1188 1A HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-299-5p 1461 1467 1A HSA-MIR-299-5P UGGUUUACCGUCCCACAUACAU
miR-30-5p 799 806 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
HSA-MIR-30C脑 uguaaacauccuacucucucucucagc
HSA-MIR-30DSZ uguaaacauccccgacuggaag
HSA-MIR-30BSZ UGUAAACAUCCUACACUCAGCU
HSA-MIR-30E-5P uguaaacauccuugacugga
miR-326 1915 1922 1A,m8 HSA-MIR-326 ccucugggcccuccag
miR-330 1720年 1727年 1A,m8 HSA-MIR-330脑 GCAAAGCACGGCCUGCAGAGA
mir-363 1768年 1774年 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
mir-378 2482 2489 1A,m8 hsa-miR-378 cuccugacuccaggucugugu
miR-410 601 607 m8 HSA-MIR-410 AAUAUAACACAGAUGGCCUGU
miR-452 420 427 1A,m8 HSA-MIR-452 UguuugcaggaaacugagaC
mir-495 394 400 m8 hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
miR-505 1257 1263 m8 HSA-MIR-505 GUCAACACUUGCUGGUUUCCUC
miR-7 1472 1478 m8 hsa-miR-7SZ Uggaagacuaguuuuuguug
mir-93.hd/291-3p/294/295/302/372/373/520 1662年 1668年 m8 hsa-miR-93脑 AAAGUGCUGUUCGUGCAGGUAG
HSA-MIR-302A UAAGUGCUUCCAUGUUUUGGUGA
HSA-MIR-302B uaagugcuuccauguuuaguag
HSA-MIR-302C UAAGUGCUUCCAUGUUUCAGUGG
HSA-MIR-302D UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 aaagugcugcgacauuugagcgu
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
HSA-MIR-520A aaagugcuucccuuguggugu
HSA-MIR-520B AAAGUGCUUCCUUUUAGAGGG
HSA-MIR-520C AAAGUGCUUCCUUUUAGAGGGUU
HSA-MIR-520D AAAGUGCUUCUCUUUGGUGGGUU