基因页：NTRK1
概括?
| GeneID | 4914 |
| Symbol | NTRK1 |
| 同义词 | MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA |
| 描述 | neurotrophic tyrosine kinase, receptor, type 1 |
| 参考 | MIM: 191315|HGNC:HGNC:8031|Ensembl:ENSG00000198400|HPRD:01869|Vega:OTTHUMG00000041304 |
| Gene type | protein-coding |
| 地图位置 | 1q21-Q22 |
| Fetal beta | 0.09 |
数据源中的基因
| Gene set name | 基因组方法 | 描述 | Info |
|---|---|---|---|
| 简历：PGCNP | 全基因组协会研究 | GWAS | |
| PMID:cooccur | 高通量文献搜索 | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | 基因组扫描荟萃分析 | Psr: 0.0235 | |
| GSMA_IIA | 基因组扫描荟萃分析（所有样品） | Psr: 0.00814 | |
| 文学 | 高通量文献搜索 | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 4 |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
大脑区域没有共表达基因
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去：0004714 | 跨膜受体蛋白酪氨酸kinase activity | NAS | neurite (GO term level: 8) | 1695324 |
| 去：0004714 | 跨膜受体蛋白酪氨酸kinase activity | 塔斯 | neurite (GO term level: 8) | 1695324|8957089 |
| GO:0043121 | 神经营养蛋白结合 | 塔斯 | 神经元（GO期限：5） | 9290260 |
| GO:0000166 | 核苷酸结合 | IEA | - | |
| 去：0004872 | 受体活性 | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005524 | ATP结合 | IEA | - | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0016301 | kinase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| 去：0007399 | 神经系统的发展 | IEA | neurite (GO term level: 5) | - |
| 去：0007190 | activation of adenylate cyclase activity | EXP | 16805430 | |
| 去：0007169 | 跨膜受体蛋白酪氨酸kinase signaling pathway | EXP | 16939974 | |
| 去：0007169 | 跨膜受体蛋白酪氨酸kinase signaling pathway | 塔斯 | 9290260 | |
| GO:0006468 | 蛋白氨基酸磷酸化 | IEA | - | |
| GO:0006468 | 蛋白氨基酸磷酸化 | NAS | - | |
| GO:0007265 | Ras protein signal transduction | EXP | 11520933 | |
| 去：0008150 | 生物_Process | ND | 1695324 | |
| 去：0007275 | 多细胞生物发育 | IEA | - | |
| 去：0030154 | cell differentiation | IEA | - | |
| 细胞分量 | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | ND | 1695324 | |
| GO:0005768 | endosome | EXP | 7806500|9182757|10629055 |16284401 |
|
| GO:0016021 | integral to membrane | NAS | - | |
| GO:0005886 | 质膜 | EXP | 11157096|16284401 | |
| GO:0005886 | 质膜 | IEA | - | |
| GO:0005887 | 质膜的积分 | 塔斯 | 9290260 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD，Biogrid | 10679771|10708759 |
| CAV1 | CAV | MSTP085 | VIP21 | caveolin 1, caveolae protein, 22kDa | - | HPRD，Biogrid | 9867838 |
| FRS2 | FRS2A |frs2alpha |SNT |SNT-1 |SNT1 | fibroblast growth factor receptor substrate 2 | TrkA interacts with FRS2-alpha. This interaction was modelled on a demonstrated interaction between human TrkA and mouse FRS2-alpha. | BIND | 10629055 |
| FRS2 | FRS2A |frs2alpha |SNT |SNT-1 |SNT1 | fibroblast growth factor receptor substrate 2 | - | HPRD，Biogrid | 10092678 |
| FRS3 | FRS2B |frs2beta |MGC17167 |SNT-2 |SNT2 | fibroblast growth factor receptor substrate 3 | TRKA与FRS2-beta相互作用。 | BIND | 10629055 |
| GIPC1 | C19orf3 |GIPC |glut1cbp |HS.6454 |IIP-1 |MGC15889 |MGC3774 |nip |RGS19IP1 |semcap | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ域含有家族，成员1 | GIPC interacts with TRKA. This interaction was modelled on a demonstrated interaction between mouse GIPC and rat TrkA. | BIND | 11251075 |
| GIPC1 | C19orf3 |GIPC |glut1cbp |HS.6454 |IIP-1 |MGC15889 |MGC3774 |nip |RGS19IP1 |semcap | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ域含有家族，成员1 | - | HPRD，Biogrid | 11251075 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD，Biogrid | 10748052|11733534 |
| KIDINS220 | 武器|MGC163482 | kinase D-interacting substrate, 220kDa | - | HPRD | 11150334|15167895 |
| matk | CHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101 | megakaryocyte-associated tyrosine kinase | - | HPRD，Biogrid | 10329710 |
| NGF | beta-ngf |hsan5 |MGC161426 |MGC161428 |NGFB | 神经生长因子（β多肽） | Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_W). | BIND | 10490030 |
| NGF | beta-ngf |hsan5 |MGC161426 |MGC161428 |NGFB | 神经生长因子（β多肽） | NGF interacts with TrkA. This interaction was modeled on a demonstrated interaction between NGF from human and TrkA from an unspecified species. | BIND | 14985763 |
| NGF | beta-ngf |hsan5 |MGC161426 |MGC161428 |NGFB | 神经生长因子（β多肽） | Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_V). | BIND | 10490030 |
| NGF | beta-ngf |hsan5 |MGC161426 |MGC161428 |NGFB | 神经生长因子（β多肽） | - | HPRD，Biogrid | 14985763 |
| NGF | beta-ngf |hsan5 |MGC161426 |MGC161428 |NGFB | 神经生长因子（β多肽） | TRKA（PDB ID：1WWW_X）和NGF（PDB ID：1WWW_V）之间的相互作用。 | BIND | 10490030 |
| NGF | beta-ngf |hsan5 |MGC161426 |MGC161428 |NGFB | 神经生长因子（β多肽） | TRKA（PDB ID：1WWW_X）和NGF（PDB ID：1WWW_W）之间的相互作用。 | BIND | 10490030 |
| NTF3 | hdnf |MGC129711 |NGF-2 |NGF2 |NT3 | 神经营养蛋白3 | Reconstituted Complex | BioGRID | 8621424 |
| NTRK1 | DKFZP781I14186 |MTC |trk |trk1 |trka |p140-trka | neurotrophic tyrosine kinase, receptor, type 1 | - | HPRD，Biogrid | 10388563 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD，Biogrid | 1715690 |
| PTPN1 | PTP1B | protein tyrosine phosphatase, non-receptor type 1 | - | HPRD，Biogrid | 12237455 |
| RAP1A | KREV-1 |krev1 |Rap1 |SMGP21 | Rap1a，Ras Oncogene家族的成员 | Affinity Capture-Western | BioGRID | 11466412 |
| RGS19 | GAIP | RGSGAIP | regulator of G-protein signaling 19 | Affinity Capture-Western | BioGRID | 11251075 |
| RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase-activating protein | - | HPRD，Biogrid | 12446789 |
| RUSC1 | DKFZp761A1822 | NESCA | RUN and SH3 domain containing 1 | - | HPRD | 15024033 |
| SH2B1 | DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2B | SH2B adaptor protein 1 | - | HPRD | 10708759 |
| SH2B1 | DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2B | SH2B adaptor protein 1 | - | HPRD，Biogrid | 9856458 |
| SH2B2 | APS | SH2B adaptor protein 2 | Affinity Capture-Western 两个杂交 |
BioGRID | 9856458 |
| SHC1 | FLJ26504 |SHC |SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | SHC与TRK相互作用。这种相互作用是在大鼠或小鼠和人类的TRK之间证明的相互作用上建模的。 | BIND | 8155326 |
| SHC1 | FLJ26504 |SHC |SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | Shc interacts with NGFR. | BIND | 8577769 |
| SHC1 | FLJ26504 |SHC |SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | ShcA interacts with TrkA. | BIND | 7542991|8610109 |8943228 |
| SHC1 | FLJ26504 |SHC |SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | Affinity Capture-Western Reconstituted Complex 两个杂交 |
BioGRID | 8183561|9856458 |10092678|10708759 |12446789 |
| SHC3 | N-Shc | NSHC | RAI | SHCC | SHC (Src homology 2 domain containing) transforming protein 3 | - | HPRD，Biogrid | 9507002 |
| SQSTM1 | A170 |OSIL |PDB3 |zip3 |p60 |p62 |p62b | 隔离1 | Affinity Capture-Western | BioGRID | 11244088|12471037 |
V.途径注释
| Pathway name | Pathway size | ＃szgr 2.0基因 | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | 该途径中的所有SZGR 2.0基因 |
| KEGG ENDOCYTOSIS | 183 | 132 | 该途径中的所有SZGR 2.0基因 |
| kegg凋亡 | 88 | 62 | 该途径中的所有SZGR 2.0基因 |
| KEGG神经营养蛋白信号传导途径 | 126 | 103 | 该途径中的所有SZGR 2.0基因 |
| KEGG PATHWAYS IN CANCER | 328 | 259 | 该途径中的所有SZGR 2.0基因 |
| KEGG THYROID CANCER | 29 | 26 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA ERK5 PATHWAY | 18 | 15 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA TRKA PATHWAY | 12 | 10 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA ACTINY PATHWAY | 20 | 14 | 该途径中的所有SZGR 2.0基因 |
| ST DIFFERENTIATION PATHWAY IN PC12 CELLS | 45 | 35 | 该途径中的所有SZGR 2.0基因 |
| SA TRKA受体 | 17 | 15 | 该途径中的所有SZGR 2.0基因 |
| PID P73PATHWAY | 79 | 59 | 该途径中的所有SZGR 2.0基因 |
| PID SHP2途径 | 58 | 46 | 该途径中的所有SZGR 2.0基因 |
| PID P75 NTR PATHWAY | 69 | 51 | 该途径中的所有SZGR 2.0基因 |
| PID TRKR途径 | 62 | 48 | 该途径中的所有SZGR 2.0基因 |
| PID PI3K PLC TRK PATHWAY | 36 | 31 | 该途径中的所有SZGR 2.0基因 |
| NGF的Reactome信号传导 | 217 | 167 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ARMS MEDIATED ACTIVATION | 17 | 17 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PROLONGED ERK ACTIVATION EVENTS | 19 | 18 | 该途径中的所有SZGR 2.0基因 |
| REACTOME SIGNALLING TO RAS | 27 | 23 | 该途径中的所有SZGR 2.0基因 |
| REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | 该途径中的所有SZGR 2.0基因 |
| REACTOME SIGNALLING TO ERKS | 36 | 30 | 该途径中的所有SZGR 2.0基因 |
| Reactome通过RIT和RIN向p38发出信号 | 15 | 14 | 该途径中的所有SZGR 2.0基因 |
| REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | 13 | 7 | 该途径中的所有SZGR 2.0基因 |
| Reactome PI3K AKT激活 | 38 | 29 | 该途径中的所有SZGR 2.0基因 |
| casorelli急性临时细胞白血病DN | 663 | 425 | 该途径中的所有SZGR 2.0基因 |
| 田中甲基化食管癌中的甲基化 | 103 | 58 | 该途径中的所有SZGR 2.0基因 |
| MYLLYKANGAS AMPLIFICATION HOT SPOT 17 | 25 | 12 | 该途径中的所有SZGR 2.0基因 |
| MYLLYKANGAS AMPLIFICATION HOT SPOT 24 | 14 | 7 | 该途径中的所有SZGR 2.0基因 |
| Mohankumar TLX1靶向DN | 193 | 112 | 该途径中的所有SZGR 2.0基因 |
| Benporath Suz12目标 | 1038 | 678 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH EED TARGETS | 1062 | 725 | 该途径中的所有SZGR 2.0基因 |
| 与H3K27me3的Benporath ES | 1118 | 744 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH PRC2 TARGETS | 652 | 441 | 该途径中的所有SZGR 2.0基因 |
| PETRETTO BLOOD PRESSURE UP | 12 | 8 | 该途径中的所有SZGR 2.0基因 |
| 丁肺癌显着突变 | 26 | 22 | 该途径中的所有SZGR 2.0基因 |
| RADAEVA RESPONSE TO IFNA1 UP | 52 | 40 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML FAB MARKERS | 191 | 131 | 该途径中的所有SZGR 2.0基因 |
| riggi ewing肉瘤祖先 | 430 | 288 | 该途径中的所有SZGR 2.0基因 |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | 该途径中的所有SZGR 2.0基因 |
| Firestein增殖 | 175 | 125 | 该途径中的所有SZGR 2.0基因 |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | 该途径中的所有SZGR 2.0基因 |
| Yagi AML与11q23重新排列 | 351 | 238 | 该途径中的所有SZGR 2.0基因 |
| ASGHARZADEH NEUROBLASTOMA POOR SURVIVAL DN | 46 | 30 | 该途径中的所有SZGR 2.0基因 |