Gene Page:NTRK2

Summary?
GeneID 4915
Symbol NTRK2
Synonyms GP145-TrkB|TRKB|trk-B
Description neurotrophic tyrosine kinase, receptor, type 2
Reference MIM:600456|HGNC:HGNC:8032|Ensembl:ENSG00000148053|HPRD:02712|Vega:OTTHUMG00000020120
Gene type protein-coding
Map location 9q22.1
Pascal p-value 0.194
Fetal beta -1.567
DMG 1 (# studies)
Support TYROSINE KINASE SIGNALING
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03628748 9 87285133 NTRK2 4.08E-8 -0.022 1.15E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ACOT8 0.94 0.90
TUSC2 0.88 0.86
MECR 0.88 0.88
UROD 0.88 0.84
MRPL17 0.87 0.88
MRPL2 0.87 0.85
SDHB 0.87 0.88
C9orf123 0.87 0.83
CDK5 0.87 0.84
COX4I1 0.87 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EIF5B -0.50 -0.58
AC010300.1 -0.47 -0.56
AC005921.3 -0.46 -0.65
SFRS18 -0.45 -0.59
ZNF814 -0.44 -0.53
ANKRD36B -0.42 -0.57
ANKRD36 -0.41 -0.54
IL3RA -0.41 -0.58
RBM25 -0.41 -0.38
AF347015.18 -0.40 -0.18

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004714 跨膜受体蛋白酪氨酸基那se activity IEA neurite (GO term level: 8) -
GO:0043121 neurotrophin binding TAS neuron (GO term level: 5) 1710174
GO:0000166 nucleotide binding IEA -
GO:0004872 receptor activity IEA -
GO:0005515 protein binding IEA -
GO:0005524 ATP binding IEA -
GO:0016740 transferase activity IEA -
GO:0016301 kinase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development IEA neurite (GO term level: 5) -
GO:0007190 activation of adenylate cyclase activity EXP 16805430
GO:0007169 跨膜受体蛋白酪氨酸基那se signaling pathway EXP 16939974
GO:0007169 跨膜受体蛋白酪氨酸基那se signaling pathway IEA -
GO:0007169 跨膜受体蛋白酪氨酸基那se signaling pathway TAS 1710174
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005887 integral to plasma membrane TAS 1710174

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BDNF MGC34632 brain-derived neurotrophic factor - HPRD,BioGRID 9312147
DYNLL1 DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1 dynein, light chain, LC8-type 1 - HPRD,BioGRID 11157096
FRS2 FRS2A | FRS2alpha | SNT | SNT-1 | SNT1 fibroblast growth factor receptor substrate 2 Reconstituted Complex BioGRID 10092678
FYN MGC45350 | SLK | SYN FYN oncogene related to SRC, FGR, YES - HPRD,BioGRID 9648856
GIPC1 C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 GIPC PDZ domain containing family, member 1 - HPRD,BioGRID 11251075
KIDINS220 ARMS | MGC163482 kinase D-interacting substrate, 220kDa - HPRD 15167895
NCK1 MGC12668 | NCK | NCKalpha NCK adaptor protein 1 - HPRD 12074588
NCK2 GRB4 | NCKbeta NCK adaptor protein 2 - HPRD,BioGRID 12074588
NTF3 HDNF | MGC129711 | NGF-2 | NGF2 | NT3 neurotrophin 3 - HPRD,BioGRID 8621424
NTF4 NT-4/5 | NT4 | NT5 | NTF5 neurotrophin 4 Interaction between TRKB (PDB ID: 1HCF_Y) and NTF4 (PDB ID: 1HCF_A). BIND 10388563|10490030
|10631974|11263982
|11738045
NTF4 NT-4/5 | NT4 | NT5 | NTF5 neurotrophin 4 Interaction between TRKB (PDB ID: 1HCF_X) and NTF4 (PDB ID: 1HCF_B). BIND 10388563|10490030
|10631974|11263982
|11738045
NTF4 NT-4/5 | NT4 | NT5 | NTF5 neurotrophin 4 - HPRD,BioGRID 11855816
NTF4 NT-4/5 | NT4 | NT5 | NTF5 neurotrophin 4 Interaction between TRKB (PDB ID: 1HCF_Y) and NTF4 (PDB ID: 1HCF_B). BIND 10388563|10490030
|10631974|11263982
|11738045
NTF4 NT-4/5 | NT4 | NT5 | NTF5 neurotrophin 4 Interaction between TRKB (PDB ID: 1HCF_X) and NTF4 (PDB ID: 1HCF_A). BIND 10388563|10490030
|10631974|11263982
|11738045
PIK3R1 GRB1 | p85 | p85-ALPHA phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Two-hybrid BioGRID 12074588
PLCG1 PLC-II | PLC1 | PLC148 | PLCgamma1 phospholipase C, gamma 1 Reconstituted Complex
Two-hybrid		 BioGRID 10092678|12074588
PTPN1 PTP1B protein tyrosine phosphatase, non-receptor type 1 - HPRD,BioGRID 12237455
SH2B1 DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2B SH2B adaptor protein 1 Two-hybrid BioGRID 12074588
SH2B1 DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2B SH2B adaptor protein 1 - HPRD 9856458
SHC1 FLJ26504 | SHC | SHCA SHC (Src homology 2 domain containing) transforming protein 1 Reconstituted Complex BioGRID 10092678
SHC3 N-Shc | NSHC | RAI | SHCC SHC (Src homology 2 domain containing) transforming protein 3 - HPRD,BioGRID 9507002
SQSTM1 A170 | OSIL | PDB3 | ZIP3 | p60 | p62 | p62B sequestosome 1 - HPRD,BioGRID 12471037


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 58 46 All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 48 38 All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 62 48 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME神经生长因子的信号通过TRKA等离子MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN 69 43 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL DN 91 53 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP 94 59 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281 186 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177 113 All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS UP 77 62 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS DN 24 13 All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS 36 25 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 88 64 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 57 45 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER E 89 44 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MF UP 47 27 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 102 67 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH DN 31 25 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS 47 28 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 45 26 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 All SZGR 2.0 genes in this pathway
HUNSBERGER EXERCISE REGULATED GENES 31 26 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
DING LUNG CANCER BY MUTATION RATE 20 18 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 DN 80 51 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266 142 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE DN 99 74 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-138 507 513 1A hsa-miR-138brain AGCUGGUGUUGUGAAUC