Gene Page:NUP98

Summary?
GeneID 4928
Symbol NUP98
Synonyms ADIR2|NUP196|NUP96
Description nucleoporin 98kDa
Reference MIM:601021|HGNC:HGNC:8068|Ensembl:ENSG00000110713|HPRD:03012|Vega:OTTHUMG00000011846
Gene type protein-coding
Map location 11p15.5
Pascal p-value 0.152
Fetal beta 0.39
eGene Caudate basal ganglia
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:McCarthy_2014 Whole Exome Sequencing analysis Whole exome sequencing of 57 trios with sporadic or familial schizophrenia.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
NUP98 chr11 3697753 G C NM_139132 p.R1650P missense SNV C P Schizophrenia DNM:McCarthy_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13- 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CREBBP CBP | KAT3A | RSTS CREB binding protein - HPRD,BioGRID 9858599
EP300 KAT3B | p300 E1A binding protein p300 Affinity Capture-Western BioGRID 9858599
IPO5 DKFZp686O1576 | FLJ43041 | IMB3 | KPNB3 | MGC2068 | RANBP5 importin 5 - HPRD 9114010
KPNB1 IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97 karyopherin (importin) beta 1 - HPRD,BioGRID 9144189
MOBKL1B C2orf6 | FLJ10788 | FLJ11595 | MATS1 | MOB1 | MOBK1B | Mob4B MOB1, Mps One Binder kinase activator-like 1B (yeast) Affinity Capture-MS BioGRID 17353931
NFX1 DKFZp779G2416 | MGC20369 | NFX2 nuclear transcription factor, X-box binding 1 Reconstituted Complex BioGRID 11073998
NUP133 FLJ10814 | MGC21133 | hNUP133 nucleoporin 133kDa - HPRD,BioGRID 11564755
NUP214 CAIN | CAN | D9S46E | MGC104525 | N214 nucleoporin 214kDa - HPRD 12589057
NUP62 DKFZp547L134 | FLJ20822 | FLJ43869 | IBSN | MGC841 | SNDI | p62 nucleoporin 62kDa - HPRD 8707840
NUP88 MGC8530 nucleoporin 88kDa - HPRD,BioGRID 12589057
NUP98 ADIR2 | NUP196 | NUP96 nucleoporin 98kDa - HPRD 12589057
NXF1 DKFZp667O0311 | MEX67 | TAP nuclear RNA export factor 1 - HPRD 10668806
NXF1 DKFZp667O0311 | MEX67 | TAP nuclear RNA export factor 1 Reconstituted Complex BioGRID 11551912
PARP11 C12orf6 | DKFZp779H0122 poly (ADP-ribose) polymerase family, member 11 Affinity Capture-MS BioGRID 17353931
QRICH2 DKFZp434P0316 glutamine rich 2 Affinity Capture-MS BioGRID 17353931
RAE1 FLJ30608 | MGC117333 | MGC126076 | MGC126077 | MIG14 | MRNP41 | Mnrp41 | dJ481F12.3 | dJ800J21.1 RAE1 RNA export 1 homolog (S. pombe) - HPRD,BioGRID 10209021
TNPO1 IPO2 | KPNB2 | MIP | MIP1 | TRN transportin 1 - HPRD,BioGRID 9144189|10875935
TNPO2 FLJ12155 | IPO3 | KPNB2B | TRN2 transportin 2 (importin 3, karyopherin beta 2b) Reconstituted Complex BioGRID 10875935
TPR - translocated promoter region (to activated MET oncogene) - HPRD,BioGRID 11248057


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 146 94 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN 59 40 All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION 45 34 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX DN 24 18 All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169 112 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 6Q21 DELETION 20 15 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE UP 79 40 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
BOYAULT肝癌子类G6 DN 19 13 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway