Gene Page:NR4A2

Summary？
基因 4929
象征 NR4A2
Synonyms hzf-3 |不| nurr1 | rnr1 | tinur
Description 核受体亚科4组成员2
Reference MIM:601828|HGNC:HGNC:7981|ENSEMBL：ENSG00000153234|HPRD：03493|Vega：Otthumg00000131950
基因类型 蛋白质编码
Map location 2q22-q23
Pascal p-value 0.055
Sherlock p-value 0.682
胎儿β 1.403
DMG 2(# studies)

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：JAFFE_2016 全基因组DNA甲基化分析 This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 3
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Association A combined odds ratio method (Sun等。2008), association studies 2 Link to SZGene
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.02395
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关关键字的命中：3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
CG06101180 2 157185558 NR4A2 4.541E-4 0.405 0.045 DMG：Wockner_2014
CG03953709 2 157189668 NR4A2 6.96E-10 -0.012 9.72E-7 DMG：JAFFE_2016
cg21512275 2 157198069 NR4A2 6.58e-9 -0.011 3.39e-6 DMG：JAFFE_2016


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0003700 转录factor activity IEA -
GO:0003707 steroid hormone receptor activity IEA -
去：0005515 蛋白质结合 IEA -
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
GO:0043565 sequence-specific DNA binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0030182 神经元分化 IEA 神经元（GO期限：8） -
GO:0042053 regulation of dopamine metabolic process IEA 多巴胺（GO期限：9） -
GO:0007399 nervous system development IEA 神经突（GO期限：5） -
去：0006355 调节转录，DNA依赖性的调节 IEA -
去：0006350 转录 IEA -
GO:0007165 信号转导 nas 7877627
GO：0045944 RNA聚合酶II启动子的转录阳性调节 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus TAS 7877627

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
Reactome通用转录途径 352 181 All SZGR 2.0 genes in this pathway
Reactome核受体转录途径 49 36 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR MARKERS DN 20 14 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央DN 634 384 All SZGR 2.0 genes in this pathway
Piccaluga血管免疫细胞淋巴瘤DN 136 86 All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
turashvili乳房正常导管与小叶 68 40 All SZGR 2.0 genes in this pathway
Casorelli急性临时细胞白血病 177 110 All SZGR 2.0 genes in this pathway
胶原蛋白凝胶中的Oswald造血干细胞 233 161 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 6hr DN的Takeda目标 41 29 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 157 91 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 10D的Takeda目标 194 122 All SZGR 2.0 genes in this pathway
Lopez间托马瘤生存时间DN 7 7 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 54 38 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出 176 123 All SZGR 2.0 genes in this pathway
Nagashima EGF信号向上 58 40 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 57 33 All SZGR 2.0 genes in this pathway
Graham正常静止与正常分裂 66 47 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 67 45 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HBZ 41 27 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HEMGN 31 21 All SZGR 2.0 genes in this pathway
riz红细胞分化6小时 40 23 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发6小时DN 514 330 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN 428 306 All SZGR 2.0 genes in this pathway
Amit EGF响应60 HELA 46 32 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 40 MCF10A 32 21 All SZGR 2.0 genes in this pathway
阿米特血清反应60 mcf10a 57 42 All SZGR 2.0 genes in this pathway
LE EGR2目标DN 108 84 All SZGR 2.0 genes in this pathway
Yagi AML Fab标记 191 131 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
伊万诺娃造血干细胞 254 164 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
伯顿成年时期峰值2小时 51 36 All SZGR 2.0 genes in this pathway
伯顿成生成1 33 24 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1 67 41 All SZGR 2.0 genes in this pathway
SAFFORD T LYMPHOCYTE ANERGY 87 54 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定 491 310 All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS DN 12 9 All SZGR 2.0 genes in this pathway
Heller HDAC靶向 317 208 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛 299 167 All SZGR 2.0 genes in this pathway
Rizki肿瘤侵入性3D 210 124 All SZGR 2.0 genes in this pathway
阿塞维多肝癌DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN 546 362 All SZGR 2.0 genes in this pathway
对Salirasib dn的Blum响应 342 220 All SZGR 2.0 genes in this pathway
吴阿尔茨海默氏病DN 19 12 All SZGR 2.0 genes in this pathway
DN YOSHIMURA MAPK8目标 366 257 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
LEE SP4 THYMOCYTE 14 11 All SZGR 2.0 genes in this pathway
李最近的胸腺移民 227 128 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS DN 17 14 All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 60 42 All SZGR 2.0 genes in this pathway
Croonquist NRA与基质刺激DN 99 65 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 1 28 19 All SZGR 2.0 genes in this pathway
PYEON CANCAR CANCAR HEAD和NECK与颈椎 193 95 All SZGR 2.0 genes in this pathway
Gutierrez Waldenstroems大球蛋白血症1 DN 9 7 All SZGR 2.0 genes in this pathway
Uzonyi对白三烯和凝血酶的反应 37 26 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
Browne HCMV感染2小时 39 30 All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化 100 70 All SZGR 2.0 genes in this pathway
ERBB2同工型5 11 8 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 33 25 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR DN 30 25 All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289 188 All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向DN 418 245 All SZGR 2.0 genes in this pathway
Smirnov对IR 6小时DN的响应 114 69 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 902 908 M8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-129-5p 643 650 1A，M8 HSA-MIR-129brain cuuuuugcgguggggcuugc
HSA-MIR-129-5p cuuuuugcgguggggcuugcu
mir-132/212 1014 1020 M8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
HSA-MIR-132brain UAACAGUCUACAGCCAUGGUCG
miR-17-5p/20/93.mr/106/519.d 1064 1070 M8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-183 1136 1142 1A HSA-MIR-183 UAUGGCACUGGUAGAAUUCACUG
miR-186 1251 1257 M8 HSA-MIR-186 CAAAGAAUUCUCCUUUUGGGCUU
mir-204/211 870 876 M8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
mir-217 567 573 M8 hsa-miR-217 uacugcaucagaacugauuggau
mir-30-5p 1279 1286 1A，M8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-320 1006 1012 M8 hsa-miR-320 aaaagcugggugagaggggcgaa
miR-33 565 571 M8 hsa-miR-33 Gugcauuguuguugcauug
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-34/449 1193 1199 M8 hsa-miR-34abrain uggcaguguuaguguguuuu
hsa-miR-34c Aggcaguguaguagcugauugc
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
HSA-MIR-449B AGGCAGUGUAUUGUUAGCUGGC
miR-34b 1194 1200 M8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-361 1243 1250 1A，M8 HSA-MIR-361brain uuaucagaaucuccagggguac
miR-365 211 217 M8 HSA-MIR-365 UAAUGCCCCUAAAAAUCCUUAU
mir-369-3p 737 743 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 737 743 M8 HSA-MIR-374 uuauaauacaAccugauaagug
miR-376c 762 768 1A hsa-miR-376c aacauagaggaaauuccacg
miR-381 1160 1166 1A HSA-MIR-381 uauacaagggcaagcucucugu
mir-409-3p 901 907 M8 HSA-MIR-409-3P cgauauguugcucggugaaccccu
mir-410 739 745 1A hsa-miR-410 aauauaacacagauggcugu
mir-450 643 649 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA
mir-455 1177 1183 M8 hsa-miR-455 UAUGUGCCUUUGGACUACAUCG
mir-539 815 821 1A hsa-miR-539 GGAGAAAUUAUCCUUGGUGUGU
miR-93.hd/291-3p/294/295/302/372/373/520 1063 1069 M8 hsa-miR-93brain aaagugcuguucgugcagguag
hsa-miR-302a uaagugcuugcauguuuguga
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
HSA-MIR-372 AAAGUGCUGCGACAUUUGAGCGU
HSA-MIR-373 Gaagugcuucgauuuggggugu
HSA-MIR-520E Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b aaagugcuuuuuuagaggg
hsa-miR-520c aaagugcuuuuuuagagggUU
hsa-miR-520d aaaguguuugugggguggguu