Gene Page:OAS3

Summary?
GeneID 4940
Symbol OAS3
Synonyms p100|p100OAS
Description 2'-5'-oligoadenylate synthetase 3
Reference MIM:603351|HGNC:HGNC:8088|Ensembl:ENSG00000111331|HPRD:04519|Vega:OTTHUMG00000169795
Gene type protein-coding
Map location 12q24.2
Pascal p-value 0.21
Fetal beta -0.277
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16458507 12 113376293 OAS3 7.91E-5 -0.32 0.025 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17092900 chr1 73003409 OAS3 4940 0 trans
rs12091025 chr1 149989802 OAS3 4940 0.08 trans
rs11205098 chr1 152717431 OAS3 4940 0.02 trans
rs4595321 chr1 232382509 OAS3 4940 0.07 trans
rs4311833 chr1 232382629 OAS3 4940 0.15 trans
snp_a-2142922 0 OAS3 4940 0.13 trans
rs12328584 chr2 60069938 OAS3 4940 0.03 trans
rs9653546 chr2 60098315 OAS3 4940 0.11 trans
rs1900263 chr2 80376061 OAS3 4940 4.503E-4 trans
rs10496239 chr2 80376968 OAS3 4940 4.503E-4 trans
rs11679783 chr2 80377391 OAS3 4940 4.503E-4 trans
rs17018721 chr2 80385148 OAS3 4940 0 trans
rs2862022 chr2 80388509 OAS3 4940 4.503E-4 trans
rs17043176 chr2 114025371 OAS3 4940 0.11 trans
rs7612673 chr3 154499328 OAS3 4940 0 trans
rs17071241 chr4 182295874 OAS3 4940 0.18 trans
rs159171 chr5 21186325 OAS3 4940 0.02 trans
rs1678893 chr5 31763244 OAS3 4940 6.959E-4 trans
snp_a-2274505 0 OAS3 4940 0 trans
rs6895909 chr5 119669742 OAS3 4940 0.13 trans
rs13176869 chr5 179203478 OAS3 4940 0 trans
rs13362722 chr6 6171044 OAS3 4940 0.11 trans
rs9396602 chr6 15766500 OAS3 4940 0.04 trans
rs16883826 chr6 91671158 OAS3 4940 0.04 trans
rs9397692 chr6 154487314 OAS3 4940 0 trans
rs10485060 chr6 154516100 OAS3 4940 0.04 trans
rs9384190 chr6 154524473 OAS3 4940 0.01 trans
rs17292544 chr6 154544809 OAS3 4940 8.001E-5 trans
rs17160749 chr7 77689922 OAS3 4940 0.04 trans
rs3779321 chr7 77691378 OAS3 4940 0.04 trans
rs11974883 chr7 78068523 OAS3 4940 0.04 trans
rs6943724 chr7 86977647 OAS3 4940 0.16 trans
rs6586742 chr8 18208340 OAS3 4940 0.17 trans
rs6994367 chr8 58489813 OAS3 4940 0.02 trans
rs16922399 chr8 58514611 OAS3 4940 0.02 trans
rs6994006 chr8 58584893 OAS3 4940 0.02 trans
rs10283729 chr9 2981636 OAS3 4940 0.06 trans
rs12349278 chr9 23523816 OAS3 4940 0.02 trans
rs10833144 chr11 19656451 OAS3 4940 0.02 trans
rs12296937 chr12 81494251 OAS3 4940 0.1 trans
rs11067420 chr12 115559121 OAS3 4940 0.19 trans
rs17061055 chr13 40835399 OAS3 4940 2.554E-4 trans
rs17066364 chr13 45515988 OAS3 4940 5.331的军医 trans
rs3783149 chr13 45582764 OAS3 4940 0.09 trans
rs7332969 chr13 45612902 OAS3 4940 5.331的军医 trans
rs16955413 chr15 29677652 OAS3 4940 5.018E-5 trans
rs16955238 chr16 81415690 OAS3 4940 0.1 trans
rs16955255 chr16 81420130 OAS3 4940 0 trans
rs16955259 chr16 81420188 OAS3 4940 0.1 trans
rs17701187 chr17 15256066 OAS3 4940 0.18 trans
rs7214294 chr17 55329212 OAS3 4940 0.08 trans
rs16979927 chr20 55019249 OAS3 4940 2.37E-7 trans
rs17347454 chrX 23347700 OAS3 4940 7.353E-6 trans
rs5952435 chrX 47321870 OAS3 4940 0.17 trans
rs6418366 0 OAS3 4940 0.08 trans
snp_a-1998882 0 OAS3 4940 0.05 trans
rs16982879 chrX 92924110 OAS3 4940 0.07 trans
rs689365 chrX 97074769 OAS3 4940 0.05 trans
rs10856133 0 OAS3 4940 0.11 trans
rs16995164 chrX 148536507 OAS3 4940 0.01 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME INTERFERON GAMMA SIGNALING 63 48 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 64 50 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159 116 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 157 91 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194 122 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175 108 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
SHIRAISHI PLZF TARGETS UP 10 5 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 44 23 All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 6HR 19 8 All SZGR 2.0 genes in this pathway
XU AKT1 TARGETS 6HR 27 18 All SZGR 2.0 genes in this pathway
多尔STAT3 DN的目标 50 34 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 32 17 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 32 20 All SZGR 2.0 genes in this pathway
ZHANG INTERFERON RESPONSE 23 14 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174 100 All SZGR 2.0 genes in this pathway
TSAI DNAJB4 TARGETS UP 13 8 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS DN 46 24 All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 DN 50 24 All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 78 48 All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 128 81 All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 95 54 All SZGR 2.0 genes in this pathway