Gene Page:OAT
概括?
| 基因 | 4942 |
| Symbol | OAT |
| Synonyms | GACR|HOGA|OATASE|OKT |
| Description | ornithine aminotransferase |
| Reference | MIM:613349|HGNC:HGNC:8091|Ensembl:ENSG00000065154|HPRD：02021|Vega:OTTHUMG00000019213 |
| Gene type | protein-coding |
| Map location | 10q26 |
| Pascal p-value | 0.329 |
| Sherlock p-value | 0.405 |
| Fetal beta | -1.193 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03487 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | 与神经相关的关键字的命中：1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10140171 | 10 | 126107537 | OAT | 2.93E-10 | -0.035 | 6.67E-7 | DMG:Jaffe_2016 |
| cg03853151 | 10 | 126107487 | OAT | 4.74E-10 | -0.009 | 8.35E-7 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ANXA7 | 0.91 | 0.88 |
| PPAP2A | 0.88 | 0.88 |
| CD55 | 0.88 | 0.86 |
| RNF13 | 0.88 | 0.85 |
| CPEB1 | 0.85 | 0.87 |
| HTATIP2 | 0.85 | 0.82 |
| ITM2B | 0.85 | 0.88 |
| ME1 | 0.84 | 0.85 |
| ATPAF1 | 0.82 | 0.79 |
| ATP6V1E1 | 0.82 | 0.71 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIAA1949 | -0.69 | -0.70 |
| SH3BP2 | -0.68 | -0.79 |
| TUBB2B | -0.68 | -0.73 |
| SH2B2 | -0.65 | -0.77 |
| marcksl1 | -0.65 | -0.64 |
| ZNF311 | -0.65 | -0.61 |
| DPYSL3 | -0.65 | -0.55 |
| NKIRAS2 | -0.65 | -0.58 |
| CCDC123 | -0.64 | -0.60 |
| C6orf134 | -0.64 | -0.55 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004587 | ornithine-oxo-acid transaminase activity | TAS | glutamate (GO term level: 6) | 3456579 |
| GO:0005515 | protein binding | 新闻学会 | 17353931 | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0030170 | pyridoxal phosphate binding | IEA | - | |
| 生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007601 | visual perception | TAS | 2793865 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005739 | mitochondrion | TAS | 2793865 | |
| GO:0005759 | mitochondrial matrix | NAS | 3456579 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ARGININE AND PROLINE METABOLISM | 54 | 39 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | 200 | 136 | 该途径中的所有SZGR 2.0基因 |
| REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | 17 | 14 | 该途径中的所有SZGR 2.0基因 |
| DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| LIU CMYB TARGETS UP | 165 | 106 | 该途径中的所有SZGR 2.0基因 |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | 该途径中的所有SZGR 2.0基因 |
| OUELLET OVARIAN CANCER INVASIVE VS LMP UP | 117 | 85 | 该途径中的所有SZGR 2.0基因 |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | 该途径中的所有SZGR 2.0基因 |
| SCHLOSSER MYC TARGETS REPRESSED BY SERUM | 159 | 93 | 该途径中的所有SZGR 2.0基因 |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | 该途径中的所有SZGR 2.0基因 |
| 金正日MYCL1放大目标DN | 20 | 12 | 该途径中的所有SZGR 2.0基因 |
| INGRAM SHH TARGETS UP | 127 | 79 | 该途径中的所有SZGR 2.0基因 |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | 该途径中的所有SZGR 2.0基因 |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP | 69 | 55 | 该途径中的所有SZGR 2.0基因 |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER CIPROFIBRATE DN | 66 | 43 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER MYC TGFA DN | 65 | 44 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER ACOX1 DN | 65 | 39 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER MYC E2F1 DN | 64 | 38 | 该途径中的所有SZGR 2.0基因 |
| TARTE PLASMA CELL VS PLASMABLAST DN | 309 | 206 | 该途径中的所有SZGR 2.0基因 |
| FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP | 151 | 100 | 该途径中的所有SZGR 2.0基因 |
| SMITH TERT TARGETS DN | 87 | 69 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER DENA DN | 74 | 45 | 该途径中的所有SZGR 2.0基因 |
| SANA RESPONSE TO IFNG DN | 85 | 56 | 该途径中的所有SZGR 2.0基因 |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER E2F1 DN | 64 | 42 | 该途径中的所有SZGR 2.0基因 |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | 该途径中的所有SZGR 2.0基因 |
| LENAOUR DENDRITIC CELL MATURATION UP | 114 | 84 | 该途径中的所有SZGR 2.0基因 |
| ZHAN V2 LATE DIFFERENTIATION GENES | 45 | 34 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 该途径中的所有SZGR 2.0基因 |
| RODWELL AGING KIDNEY NO BLOOD DN | 150 | 93 | 该途径中的所有SZGR 2.0基因 |
| RODWELL AGING KIDNEY DN | 145 | 88 | 该途径中的所有SZGR 2.0基因 |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | 该途径中的所有SZGR 2.0基因 |
| Creighton内分泌疗法抗性3 | 720 | 440 | 该途径中的所有SZGR 2.0基因 |
| Heller HDAC靶向被甲基化的沉默 | 461 | 298 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN | 354 | 216 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER DN | 540 | 340 | 该途径中的所有SZGR 2.0基因 |
| Acevedo肝癌，H3K27me3 UP | 295 | 149 | 该途径中的所有SZGR 2.0基因 |
| Mootha Human Mitodb 6 2002 | 429 | 260 | 该途径中的所有SZGR 2.0基因 |
| MOOTHA MITOCHONDRIA | 447 | 277 | 该途径中的所有SZGR 2.0基因 |
| BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP | 47 | 30 | 该途径中的所有SZGR 2.0基因 |
| Ichiba移植与宿主疾病35D DN | 49 | 34 | 该途径中的所有SZGR 2.0基因 |
| 金ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | 该途径中的所有SZGR 2.0基因 |
| 金ALL DISORDERS CALB1 CORR UP | 548 | 370 | 该途径中的所有SZGR 2.0基因 |
| WIERENGA PML INTERACTOME | 42 | 23 | 该途径中的所有SZGR 2.0基因 |
| MIKHAYLOVA OXIDATIVE STRESS RESPONSE VIA VHL DN | 6 | 5 | 该途径中的所有SZGR 2.0基因 |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | 该途径中的所有SZGR 2.0基因 |