Gene Page:OPRK1

Summary?
GeneID 4986
Symbol OPRK1
Synonyms K-OR-1|KOR|KOR-1|OPRK
Description opioid receptor, kappa 1
Reference MIM:165196|HGNC:HGNC:8154|Ensembl:ENSG00000082556|HPRD:01309|Vega:OTTHUMG00000164276
Gene type protein-coding
Map location 8q11.2
Pascal p-value 0.939
DMG 1 (# studies)
eGene Cerebellar Hemisphere
元
Support GPCR SIGNALLING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统的搜索页ubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09999109 8 54164310 OPRK1 4.82E-7 -0.392 0.006 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
YIPF3 0.91 0.88
PSMF1 0.89 0.86
PSMD3 0.89 0.88
DDOST 0.89 0.89
ERAL1 0.89 0.85
EIF2B2 0.89 0.84
TRAP1 0.88 0.84
EIF3I 0.88 0.86
PSMC4 0.88 0.85
DCTN2 0.88 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.78 -0.77
AF347015.31 -0.77 -0.77
AF347015.8 -0.76 -0.77
MT-CYB -0.75 -0.77
AF347015.33 -0.74 -0.76
AF347015.21 -0.74 -0.78
AF347015.2 -0.74 -0.77
AF347015.27 -0.73 -0.77
AF347015.26 -0.71 -0.76
AF347015.15 -0.69 -0.73

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity IEA -
GO:0005515 protein binding 新闻学会 16431922
GO:0004987 kappa-opioid receptor activity IEA -
GO:0004987 kappa-opioid receptor activity TAS 8755601
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 7624359
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007193 G-protein signaling, adenylate cyclase inhibiting pathway TAS 7624359
GO:0007165 signal transduction IEA -
GO:0007610 behavior TAS 7624359
GO:0007600 sensory perception TAS 7624359
GO:0006955 immune response TAS 8755601
GO:0019079 viral genome replication TAS 8755601
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 7624359

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
BIOCARTA DREAM PATHWAY 14 13 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 82 58 All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353 226 All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP 102 64 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204 114 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174 100 All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 142 80 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 150 99 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-381 3517 3523 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU