Gene Page:ACO2

Summary?
GeneID 50
Symbol ACO2
Synonyms ACONM|HEL-S-284|ICRD|OCA8|OPA9
Description aconitase 2
Reference MIM:100850|HGNC:HGNC:118|Ensembl:ENSG00000100412|HPRD:00012|Vega:OTTHUMG00000030544
Gene type protein-coding
Map location 22q13.2
Pascal p-value 0.018
Sherlock p-value 0.644
Support G2Cdb.human_mitochondria
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATP6AP1 0.91 0.91
SEZ6L2 0.89 0.91
CHPF 0.87 0.90
LENG4 0.87 0.88
FAM127A 0.86 0.87
PCYOX1L 0.86 0.85
GRINA 0.86 0.85
PNPLA6 0.86 0.84
CLSTN3 0.85 0.88
PTPRN2 0.85 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.60 -0.46
AF347015.18 -0.55 -0.46
MT-CO2 -0.55 -0.43
AC098691.2 -0.54 -0.49
NOSTRIN -0.53 -0.42
AF347015.8 -0.53 -0.43
AF347015.2 -0.53 -0.40
AF347015.31 -0.52 -0.42
AF347015.33 -0.52 -0.41
AP002478.3 -0.52 -0.45

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003994 aconitate hydratase activity EXP 1946331
GO:0003994 aconitate hydratase activity IEA -
GO:0005506 iron ion binding IDA 9630632
GO:0016829 lyase activity IEA -
GO:0046872 metal ion binding IEA -
GO:0051539 4 iron, 4 sulfur cluster binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006101 citrate metabolic process IDA 9630632
GO:0006099 tricarboxylic acid cycle IDA 9630632
GO:0006091 generation of precursor metabolites and energy TAS 9630632
GO:0008152 metabolic process IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 18029348
GO:0005739 mitochondrion TAS 9630632
GO:0005759 mitochondrial matrix EXP 1946331

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CITRATE CYCLE TCA CYCLE 32 23 All SZGR 2.0 genes in this pathway
KEGG GLYOXYLATE AND DICARBOXYLATE METABOLISM 16 12 All SZGR 2.0 genes in this pathway
BIOCARTA KREB PATHWAY 8 8 All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 48 32 All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 141 85 All SZGR 2.0 genes in this pathway
REACTOME MITOCHONDRIAL PROTEIN IMPORT 58 24 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME CITRIC ACID CYCLE TCA CYCLE 26 16 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 139 83 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182 116 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151 100 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 51 35 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SUBGROUPS 30 20 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C6 39 27 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 40 31 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5 126 78 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN 54 43 All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 37 26 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
MOOTHA TCA 16 13 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G5 12 8 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-203.1 292 298 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG