Gene Page:ORC5
概括?
| 基因 | 5001 |
| 象征 | ORC5 |
| Synonyms | ORC5L|ORC5P|ORC5T|PPP1R117 |
| Description | 原点识别复合物亚基5 |
| Reference | MIM:602331|HGNC:HGNC:8491|Ensembl:ENSG00000164815|HPRD:09086|Vega：Otthumg00000157275 |
| Gene type | protein-coding |
| Map location | 7q22.1 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.73 |
| eGene | Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
第一节遗传学和表观遗传学注释
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1431904 | chr2 | 168464869 | ORC5 | 5001 | 0.07 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SEPT2 | 0.82 | 0.76 |
| PLOD2 | 0.79 | 0.71 |
| CAT | 0.76 | 0.65 |
| YAP1 | 0.76 | 0.66 |
| HEATR5A | 0.76 | 0.68 |
| aldh9a1 | 0.75 | 0.71 |
| ELP4 | 0.74 | 0.72 |
| ITGA6 | 0.74 | 0.75 |
| DARS | 0.73 | 0.68 |
| PGM2 | 0.73 | 0.58 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.28 | -0.19 |
| MYL3 | -0.28 | -0.22 |
| C2ORF82 | -0.27 | -0.28 |
| AC104794.1 | -0.26 | -0.20 |
| CA4 | -0.26 | -0.20 |
| AL022328.1 | -0.26 | -0.19 |
| A1BG | -0.26 | -0.30 |
| SLC26A4 | -0.25 | -0.21 |
| AC044839.2 | -0.24 | -0.18 |
| AC098691.2 | -0.24 | -0.19 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| CDC7 | CDC7L1 | HsCDC7 | Hsk1 | MGC117361 | MGC126237 | MGC126238 | huCDC7 | cell division cycle 7 homolog (S. cerevisiae) | - | HPRD | 15232106 |
| DBF4 | ASK | CHIF | DBF4A | ZDBF1 | DBF4 homolog (S. cerevisiae) | 两个杂交 | BioGRID | 12614612 |
| MCM2 | BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19 | minichromosome maintenance complex component 2 | 两个杂交 | BioGRID | 12614612 |
| MCM3 | HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFB | minichromosome maintenance complex component 3 | 两个杂交 | BioGRID | 12614612 |
| MCM4 | CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21 | minichromosome maintenance complex component 4 | 两个杂交 | BioGRID | 12614612 |
| MCM7 | CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146 | minichromosome maintenance complex component 7 | - | HPRD,BioGRID | 12614612 |
| ORC1L | HSORC1 | ORC1 | PARC1 | origin recognition complex, subunit 1-like (yeast) | 两个杂交 | BioGRID | 12614612 |
| ORC2L | ORC2 | origin recognition complex, subunit 2-like (yeast) | Affinity Capture-Western 共纯化 Reconstituted Complex 两个杂交 |
BioGRID | 9765232|11323433 |11395502|12614612 |
| ORC3L | LAT | LATHEO | ORC3 | origin recognition complex, subunit 3-like (yeast) | - | HPRD | 11395502|15232106 |
| ORC3L | LAT | LATHEO | ORC3 | origin recognition complex, subunit 3-like (yeast) | Affinity Capture-Western 共纯化 Reconstituted Complex 两个杂交 |
BioGRID | 10402192|11323433 |11395502|12614612 |
| ORC4L | ORC4 | ORC4P | origin recognition complex, subunit 4-like (yeast) | Affinity Capture-Western 共纯化 两个杂交 |
BioGRID | 9765232|11395502 |12614612 |
| ORC4L | ORC4 | ORC4P | origin recognition complex, subunit 4-like (yeast) | - | HPRD | 11323433 |
| ORC5L | ORC5 | ORC5P | ORC5T | origin recognition complex, subunit 5-like (yeast) | 两个杂交 | BioGRID | 12614612 |
| ORC6L | ORC6 | origin recognition complex, subunit 6 like (yeast) | 两个杂交 | BioGRID | 12614612 |
| RPA2 | REPA2 | RPA32 | 复制蛋白A2, 32 kda | 两个杂交 | BioGRID | 12614612 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL CYCLE | 128 | 84 | 该途径中的所有SZGR 2.0基因 |
| Biocarta MCM途径 | 18 | 8 | 该途径中的所有SZGR 2.0基因 |
| REACTOME激活OF THE PRE REPLICATIVE COMPLEX | 31 | 16 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CELL CYCLE | 421 | 253 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ORC1 REMOVAL FROM CHROMATIN | 67 | 37 | 该途径中的所有SZGR 2.0基因 |
| REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | 10 | 5 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | 11 | 5 | 该途径中的所有SZGR 2.0基因 |
| REACTOME M G1 TRANSITION | 81 | 45 | 该途径中的所有SZGR 2.0基因 |
| REACTOME G1 S TRANSITION | 112 | 63 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | 56 | 31 | 该途径中的所有SZGR 2.0基因 |
| DNA的反应组合成 | 92 | 53 | 该途径中的所有SZGR 2.0基因 |
| REACTOME MITOTIC G1 G1 S PHASES | 137 | 79 | 该途径中的所有SZGR 2.0基因 |
| REACTOME MITOTIC M M G1 PHASES | 172 | 98 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | 65 | 36 | 该途径中的所有SZGR 2.0基因 |
| REACTOME DNA REPLICATION | 192 | 110 | 该途径中的所有SZGR 2.0基因 |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | 35 | 17 | 该途径中的所有SZGR 2.0基因 |
| REACTOME激活OF ATR IN RESPONSE TO REPLICATION STRESS | 38 | 18 | 该途径中的所有SZGR 2.0基因 |
| REACTOME G2 M CHECKPOINTS | 45 | 23 | 该途径中的所有SZGR 2.0基因 |
| REACTOME S PHASE | 109 | 66 | 该途径中的所有SZGR 2.0基因 |
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| ZHOU INFLAMMATORY RESPONSE FIMA DN | 284 | 156 | 该途径中的所有SZGR 2.0基因 |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | 该途径中的所有SZGR 2.0基因 |
| KIM WT1 TARGETS DN | 459 | 276 | 该途径中的所有SZGR 2.0基因 |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | 该途径中的所有SZGR 2.0基因 |
| HAHTOLA MYCOSIS FUNGOIDES SKIN UP | 177 | 113 | 该途径中的所有SZGR 2.0基因 |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | 该途径中的所有SZGR 2.0基因 |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | 该途径中的所有SZGR 2.0基因 |
| Dacosta UV响应通过ERCC3公共DN | 483 | 336 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | 该途径中的所有SZGR 2.0基因 |
| KAUFFMANN DNA REPLICATION GENES | 147 | 87 | 该途径中的所有SZGR 2.0基因 |
| BASSO B LYMPHOCYTE NETWORK | 143 | 96 | 该途径中的所有SZGR 2.0基因 |
| Nemeth炎症反应LPS DN | 32 | 25 | 该途径中的所有SZGR 2.0基因 |
| JAIN NFKB SIGNALING | 75 | 44 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML SURVIVAL | 129 | 87 | 该途径中的所有SZGR 2.0基因 |
| TACI DN的Moreaux多发性骨髓瘤 | 172 | 107 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT DN | 165 | 106 | 该途径中的所有SZGR 2.0基因 |
| HU GENOTOXIC DAMAGE 4HR | 35 | 28 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | 该途径中的所有SZGR 2.0基因 |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| SANSOM APC TARGETS | 212 | 121 | 该途径中的所有SZGR 2.0基因 |
| Heller HDAC靶向被甲基化的沉默 | 461 | 298 | 该途径中的所有SZGR 2.0基因 |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | 该途径中的所有SZGR 2.0基因 |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | 该途径中的所有SZGR 2.0基因 |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 该途径中的所有SZGR 2.0基因 |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR | 152 | 88 | 该途径中的所有SZGR 2.0基因 |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | 该途径中的所有SZGR 2.0基因 |