Gene Page:P2RX4

Summary?
GeneID 5025
Symbol P2RX4
Synonyms P2X4 | P2X4R
Description purinergic receptor P2X 4
Reference MIM:600846|HGNC:HGNC:8535|Ensembl:ENSG00000135124|HPRD:09017|Vega:OTTHUMG00000169155
Gene type protein-coding
Map location 12q24.32
Pascal p-value 0.033
Sherlock p-value 0.666
eGene 元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding ISS Neurotransmitter (GO term level: 4) 17785580
GO:0001614 purinergic nucleotide receptor activity IDA 9016352
GO:0001614 purinergic nucleotide receptor activity IMP 11606481
GO:0004872 receptor activity IEA -
GO:0004931 ATP-gated cation channel activity IDA 9016352
GO:0004931 ATP-gated cation channel activity IEA -
GO:0005507 copper ion binding ISS 12819199
GO:0005524 ATP binding IEA -
GO:0005216 ion channel activity IEA -
GO:0008270 zinc ion binding ISS 12819199
GO:0042803 protein homodimerization activity NAS 17895406
GO:0045296 cadherin binding 新闻学会 12088286
GO:0046982 protein heterodimerization activity ISS 17785580
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0060079 regulation of excitatory postsynaptic membrane potential IEA neuron, Synap (GO term level: 10) -
GO:0002028 regulation of sodium ion transport ISS 17785580
GO:0001894 tissue homeostasis NAS 17264311
GO:0008217 regulation of blood pressure IMP 11606481|15130891
GO:0010524 positive regulation of calcium ion transport into cytosol IDA 10969036
GO:0010524 positive regulation of calcium ion transport into cytosol IMP 10899068
GO:0007165 signal transduction IDA 9016352
GO:0010614 negative regulation of cardiac muscle hypertrophy IMP 15130891
GO:0006816 calcium ion transport IEA -
GO:0006811 ion transport IEA -
去:0006809 nitric oxide biosynthetic process IEA -
GO:0042981 regulation of apoptosis IDA 17264311
GO:0042311 vasodilation IEA -
GO:0033198 response to ATP IDA 9016352
GO:0042118 endothelial cell activation TAS 12088286
GO:0032308 positive regulation of prostaglandin secretion NAS 10899068
GO:0019233 sensory perception of pain ISS 14978347
GO:0034405 response to fluid shear stress IDA 10969036
GO:0050850 positive regulation of calcium-mediated signaling IDA 10969036
GO:0050850 positive regulation of calcium-mediated signaling IMP 10899068
GO:0045429 positive regulation of nitric oxide biosynthetic process NAS 10899068
GO:0055117 regulation of cardiac muscle contraction IMP 11606481|15130891
GO:0055119 relaxation of cardiac muscle IMP 11606481|15130891
GO:0051899 membrane depolarization IDA 9016352
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane ISS 17785580
GO:0005887 integral to plasma membrane TAS 9016352
GO:0048471 perinuclear region of cytoplasm IDA 12088286
GO:0030054 cell junction IDA 12088286
GO:0045177 apical part of cell IEA -

部分诉通路注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 44 30 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP 108 75 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221 150 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217 131 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP1 136 76 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 89 47 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428 246 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-17-5p/20/93.mr/106/519.d 381 388 1A,m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU