Gene Page:pafah1b1

Summary？
GeneID 5048
Symbol pafah1b1
Synonyms lis1 | lis2 | mdcr | mds | pafah
Description 血小板激活因子乙酰水合酶1B调节亚基1
Reference MIM：601545|HGNC：HGNC：8574|Ensembl:ENSG00000007168|HPRD: 03329|Vega：Otthumg00000177574
基因类型 蛋白质编码
Map location 17p13.3
Pascal p-value 0.043
夏洛克假定值 0.446
胎儿β 0.455
Support INTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
GO_Annotation 将与神经相关的关键字映射到基因本体论注释 Hits with neuro-related keywords: 8
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.1894

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CDCA7L 0.87 0.61
CDK2 0.86 0.48
Gli3 0.86 0.68
WEE1 0.85 0.35
地狱 0.85 0.25
梅尔克 0.85 0.27
法奇 0.85 0.26
tead2 0.85 0.40
KIF23 0.85 0.19
CCNB2 0.85 0.28
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ADAP1 -0.34 -0.28
FXYD7 -0.33 -0.25
P2RX5 -0.32 -0.31
KCNF1 -0.32 -0.36
PINK1 -0.32 -0.33
KAZALD1 -0.32 -0.24
rltpr -0.32 -0.26
asphd1 -0.31 -0.20
CKMT1A -0.31 -0.29
SULT4A1 -0.31 -0.40

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0008201 肝素约束 ISS 8028668
GO:0008017 微管结合 IEA -
GO:0051219 phosphoprotein binding ISS -
GO：0042803 蛋白质同构化活性 IEA -
GO:0043274 phospholipase binding ISS 8028668
GO:0034452 dynactin binding ISS 11056532
GO:0045502 动力蛋白结合 IDA 11889140
Biological process 去学期 证据 神经关键字 PubMed ID
去：0007405 神经细胞增殖 IEA 神经元（GO期限：8） -
GO:0001764 神经元迁移 IEA 神经元（GO期限：8） -
GO:0007268 synaptic transmission IEA 神经元，突触，神经递质（GO期限：6） -
GO:0021540 call体形态发生 IMP neuron, axon (GO term level: 15) 9063735
GO:0048854 brain morphogenesis IMP Brain (GO term level: 8) 9063735
GO:0008090 retrograde axon cargo transport IEA axon (GO term level: 9) -
GO：0021819 layer formation in the cerebral cortex ISS Glial (GO term level: 15) -
GO:0007399 nervous system development IEA 神经突（GO期限：5） -
GO:0000132 establishment of mitotic spindle orientation IMP 11056532
GO:0000226 microtubule cytoskeleton organization IEA -
GO:0001675 acrosome formation IEA -
GO:0016042 lipid catabolic process IEA -
GO:0007049 cell cycle IEA -
GO:0007067 mitosis IEA -
GO:0008344 成人运动行为 IEA -
去：0007611 learning or memory IEA -
GO:0006810 transport IEA -
GO:0007275 multicellular organismal development IEA -
GO:0030154 细胞分化 IEA -
GO:0030036 actin cytoskeleton organization ISS 10729324
GO:0021987 cerebral cortex development IEA -
GO：0050885 神经肌肉过程控制平衡 IEA -
GO:0021766 hippocampus development IEA -
GO:0032319 RHO GTPase活性的调节 ISS 10729324
去：0051301 cell division IEA -
GO：0047496 vesicle transport along microtubule IEA -
GO:0046469 platelet activating factor metabolic process ISS 8028668
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0000235 星体微管 IDA 11940666
GO:0000776 kinetochore IDA 11056532|11889140|11940666
GO:0005813 centrosome IEA -
GO:0005819 spindle IEA -
GO:0005829 细胞质 ISS 8028668
去：0005874 microtubule IEA -
去：0005875 microtubule associated complex IDA 11889140
去：0005634 nucleus IEA -
去：0005737 cytoplasm IEA -
GO:0016020 membrane IEA -
GO:0005938 细胞皮质 IDA 11940666
GO：0048471 细胞质的核周区 ISS -
GO：0031513 非运动原发性纤毛 ISS -
GO：0031512 motile primary cilium IEA -
GO:0031252 cell leading edge IEA -
GO：0031965 核膜 IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
夹子1 CLIP | CLIP-170 | CLIP170 | CYLN1 | MGC131604 | RSN CAP-GLY domain containing linker protein 1 - HPRD,BioGRID 11940666
CSNK2A1 CK2A1 | CKII 酪蛋白激酶2，α1多肽 - HPRD,BioGRID 10491172
DAB1 - 残疾同源1（果蝇） - HPRD 14578885
DCTN1 DAP-150 |DP-150 |HMN7B |P135 Dynactin 1（P150，胶合同源物，果蝇） - HPRD,BioGRID 11889140 | 14584027
DCTN2 DCTN50 | DYNAMITIN | RBP50 Dynactin 2（P50） Two-hybrid Biogrid 11889140
DCX DBCN | DC | LISX | SCLH | XLIS Doublecortin - HPRD,BioGRID 11001923
DNAI1 CILD1 | ICS | MGC26204 | PCD 动力蛋白，轴突，中间链1 - HPRD 11889140
DYNC1H1 DHC1 |DHC1A |DKFZP686P2245 |dnch1 |DNCL |dnecl |dyhc |DNCHC1 |HL-3 |KIAA0325 | p22 dynein, cytoplasmic 1, heavy chain 1 亲和力捕获 - 韦斯特恩
Two-hybrid		 Biogrid 11889140
HSPH1 DKFZp686M05240 | HSP105 | HSP105A | HSP105B | KIAA0201 | NY-CO-25 heat shock 105kDa/110kDa protein 1 - HPRD 14733918
KARS KARS2 | KIAA0070 | KRS lysyl-tRNA synthetase Two-hybrid Biogrid 16169070
NDE1 FLJ20101 | HOM-TES-87 | NUDE | NUDE1 裸核分布基因E同源1（A. nidulans） - HPRD 11163258
NDEL1 DKFZp451M0318 | EOPA | MITAP1 | NUDEL nudE nuclear distribution gene E homolog (A. nidulans)-like 1 - HPRD,BioGRID 11163260
nudc hnudc |mnudc |NPD011 核分布基因C同源物（A. nidulans） - HPRD,BioGRID 9601647|11734602
pafah1b1 LIS1 | LIS2 | MDCR | MDS | PAFAH platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa - HPRD,BioGRID 11889140
pafah1b2 - 血小板激活因子乙酰水合酶，同工型IB，β亚基30KDA - HPRD,BioGRID 10727864
pafah1b3 - platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa - HPRD,BioGRID 10727864
tuba1a B-ALPHA-1 | FLJ25113 | LIS3 | TUBA3 tubulin, alpha 1a 重构的复合物 Biogrid 9384577


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg醚脂质代谢 33 15 All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY 29 29 All SZGR 2.0 genes in this pathway
PID LIS1途径 28 22 All SZGR 2.0 genes in this pathway
反应组细胞周期 421 253 All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC 325 185 All SZGR 2.0 genes in this pathway
Reactome募集有丝分裂的中心体蛋白和复合物 66 43 All SZGR 2.0 genes in this pathway
来自有丝分裂中心体NLP的反应组损失 59 38 All SZGR 2.0 genes in this pathway
Reactome有丝分裂M M G1相 172 98 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
Reactome DNA复制 192 110 All SZGR 2.0 genes in this pathway
反应组有丝分裂起点 87 51 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
lastowska神经母细胞瘤复制编号 181 108 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
Dairkee Tert目标DN 124 79 All SZGR 2.0 genes in this pathway
Nuytten Nipp1靶向 769 437 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
BMYB多态性变体DN的SCHWAB靶标 17 12 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
Georges细胞周期miR192目标 62 46 All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标 893 528 All SZGR 2.0 genes in this pathway
Shen Smarca2目标 424 268 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169 102 All SZGR 2.0 genes in this pathway
戈德拉斯体内平衡增殖 171 102 All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn 546 351 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP 36 27 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 91 64 All SZGR 2.0 genes in this pathway
外邦紫外线响应集群D6 37 25 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 128 93 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病初期DN 165 106 All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应 318 220 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
LY AGING OLD DN 56 35 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153 112 All SZGR 2.0 genes in this pathway
Sesto对UV C5的反应 46 36 All SZGR 2.0 genes in this pathway
外邦紫外线低剂量DN 67 46 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN 101 64 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 47 31 All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14删除 74 40 All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 92 64 All SZGR 2.0 genes in this pathway
Matzuk精子分化 37 26 All SZGR 2.0 genes in this pathway
mir15a和mir16 1的Bonci目标 91 75 All SZGR 2.0 genes in this pathway
米利假足 518 299 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
Rampon丰富学习环境早期DN 10 10 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 2739 2746 1A，M8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-10 1040 1046 M8 hsa-miR-10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10b uacccuguagaaccgaauuugu
mir-101 181 187 1A hsa-miR-101 uacaguacugauaacugaag
miR-124/506 2549 2555 M8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-125/351 2362 2369 1A，M8 hsa-miR-125bbrain ucccugagacccuaacuuguga
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
mir-130/301 2868 2874 M8 hsa-miR-130abrain cagugcaauguaaaaggggau
hsa-miR-301 cagugcaauaugucaaagc
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-144 180 187 1A，M8 HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497 2005 2012 1A，M8 HSA-MIR-15Abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 CAGCAGCACACUGUGGUUUGU
HSA-MIR-15Abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 CAGCAGCACACUGUGGUUUGU
HSA-MIR-15Abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 CAGCAGCACACUGUGGUUUGU
miR-150 2287 2294 1A，M8 HSA-MIR-150 UCUCCCAACCCUUGUACCAGUG
miR-151 202 208 1A HSA-MIR-151brain Acuagacugaagcucuugagg
miR-17-5p/20/93.mr/106/519.d 2870 2877 1A，M8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-181 3673 3679 1A hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 566 573 1A，M8 HSA-MIR-182 UUUGGCAAUGGUAGAACUCACA
miR-194 139 145 1A HSA-MIR-194 uguaacagcaacuccauga
mir-205 3555 3561 M8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
mir-214 2304 2310 M8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-22 667 673 1A hsa-miR-22brain Aagcugccaguugaagaacugu
mir-223 3549 3555 1A hsa-miR-223 ugucuuugucaauacccc
miR-25/32/92/363/367 893 899 M8 hsa-miR-25brain Cauugcacuugucucggucuga
hsa-miR-32 uauugcacauacuaaguugc
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
HSA-MIR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ uauugcacucgucccgcgcuc
miR-324-5p 38 44 1A hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU
mir-330 2638 2644 M8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-339 1039 1045 M8 hsa-miR-339 ucccuccuccaggagcuca
miR-376c 431 438 1A，M8 hsa-miR-376c aacauagaggaaauuccacg
miR-381 176 182 1A HSA-MIR-381 UAUACAAGGGCAAGCUCUCUGU
miR-496 101 108 1A，M8 HSA-MIR-496 AUUACAUGGCCAAUCUC
mir-503 2006 2012 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG
mir-543 137 143 1A hsa-miR-543 aaacauucgcggugcacuucu
miR-96 567 573 1A hsa-miR-96brain uuuggcacuagcacauuuuugc