Gene Page:ATP5B

Summary?
GeneID 506
Symbol ATP5B
Synonyms ATPMB|ATPSB|HEL-S-271
Description ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Reference MIM:102910|HGNC:HGNC:830|Ensembl:ENSG00000110955|HPRD:00044|
Gene type protein-coding
Map location 12q13.13
Pascal p-value 0.33
Sherlock p-value 0.041
Fetal beta -0.437
DMG 1 (# studies)
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_mitochondria
G2Cdb.human_Synaptosome
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0296

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17616707 12 57039822 ATP5B 6.11E-10 -0.011 9.15E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SUCLG1 0.94 0.91
PSMA6 0.92 0.91
MRPL1 0.92 0.93
ZNHIT3 0.92 0.90
MRPL15 0.91 0.90
CHMP5 0.90 0.88
NFU1 0.90 0.91
VPS29 0.89 0.91
MRPL47 0.89 0.89
C11orf73 0.89 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM38A -0.57 -0.62
PPP1R13L -0.56 -0.55
AF347015.26 -0.55 -0.53
TRIM56 -0.55 -0.59
AF347015.18 -0.55 -0.50
DOCK6 -0.54 -0.56
MYH9 -0.54 -0.53
AF347015.2 -0.54 -0.51
RRBP1 -0.53 -0.56
TENC1 -0.52 -0.58

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding IPI 11410595
GO:0005524 ATP binding IEA -
GO:0016787 hydrolase activity IEA -
GO:0005215 transporter activity NAS 2870059
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism IEA -
去:0016887 ATPase activity IDA 12110673
GO:0042288 MHC class I protein binding IDA 17643490
GO:0043499 eukaryotic cell surface binding IDA 10077593
GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism IEA -
GO:0046872 metal ion binding IEA -
GO:0046961 hydrogen ion transporting ATPase activity, rotational mechanism IMP 17510399
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0001525 angiogenesis IMP 17510399
GO:0006091 generation of precursor metabolites and energy NAS 2870059
GO:0006811 ion transport IEA -
GO:0015992 proton transport IMP 17510399
GO:0015986 ATP synthesis coupled proton transport IEA -
GO:0051453 regulation of intracellular pH IMP 17510399
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005739 mitochondrion IDA 2870059
GO:0005753 mitochondrial proton-transporting ATP synthase complex IDA 12110673
GO:0005753 mitochondrial proton-transporting ATP synthase complex NAS 2900241
GO:0005754 mitochondrial proton-transporting ATP synthase, catalytic core NAS 2687158|2870059
GO:0005759 mitochondrial matrix EXP 4517936
GO:0005759 mitochondrial matrix NAS 2687158
GO:0016021 integral to membrane IEA -
GO:0009986 cell surface IDA 17510399
GO:0005886 plasma membrane IDA 10077593
GO:0016469 proton-transporting two-sector ATPase complex IEA -
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG OXIDATIVE PHOSPHORYLATION 135 73 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE 133 78 All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185 109 All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 141 85 All SZGR 2.0 genes in this pathway
REACTOME MITOCHONDRIAL PROTEIN IMPORT 58 24 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS 98 56 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING 16 9 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE DN 51 35 All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201 127 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 88 60 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
MOOTHA VOXPHOS 87 51 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR DN 25 15 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
击倒卡路里限制肌肉DN 87 59 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX UP 20 14 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 52 32 All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 92 68 All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 37 26 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 98 63 All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217 122 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
MIKHAYLOVA OXIDATIVE STRESS RESPONSE VIA VHL UP 7 6 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway