Gene Page:PAK2

Summary?
GeneID 5062
Symbol PAK2
Synonyms PAK65|PAKgamma
Description p21 protein (Cdc42/Rac)-activated kinase 2
Reference MIM:605022|HGNC:HGNC:8591|Ensembl:ENSG00000180370|HPRD:05428|Vega:OTTHUMG00000155534
Gene type protein-coding
Map location 3q29
Pascal p-value 0.019
Sherlock p-value 0.099
Fetal beta 1.644
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0435

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02319016 3 196469777 PAK2 5.425E-4 0.377 0.048 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1983892 chr6 41537567 PAK2 5062 0.01 trans
rs1502683 chr9 85599579 PAK2 5062 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NONO 0.96 0.94
APEX1 0.96 0.94
KDM1 0.95 0.94
HNRNPL 0.95 0.94
RBMX 0.95 0.95
RBBP4 0.95 0.94
FUBP1 0.94 0.92
SMAD4 0.94 0.90
SF3B3 0.94 0.92
TH1L 0.94 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.71 -0.88
AF347015.27 -0.71 -0.88
MT-CO2 -0.70 -0.88
C5orf53 -0.69 -0.76
AF347015.33 -0.69 -0.86
MT-CYB -0.68 -0.87
HLA-F -0.68 -0.76
AIFM3 -0.68 -0.77
AF347015.8 -0.68 -0.88
IFI27 -0.66 -0.83

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IDA 11805089
GO:0016740 transferase activity IEA -
GO:0042802 identical protein binding 新闻学会 16837009
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0001558 regulation of cell growth IEA -
GO:0006469 negative regulation of protein kinase activity TAS 10748018
GO:0007165 signal transduction TAS 7744004
GO:0006915 apoptosis IEA -
GO:0044419 interspecies interaction between organisms IEA -
GO:0046777 protein amino acid autophosphorylation IDA 11805089
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 15234964
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IEA -
GO:0016020 membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ABI1 ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1 abl-interactor 1 - HPRD 11956071
ABI3 NESH | SSH3BP3 ABI family, member 3 - HPRD,BioGRID 11956071
ABL1 ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl c-abl oncogene 1, receptor tyrosine kinase - HPRD,BioGRID 11121037
ARHGEF7 BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXB ρ鸟嘌呤核苷酸交换因子(GEF) 7 - HPRD,BioGRID 12226077
CDC42 CDC42Hs | G25K cell division cycle 42 (GTP binding protein, 25kDa) - HPRD,BioGRID 10320322
DOCK2 FLJ46592 | KIAA0209 dedicator of cytokinesis 2 Reconstituted Complex BioGRID 12176041
GIT1 - G protein-coupled receptor kinase interacting ArfGAP 1 Affinity Capture-MS BioGRID 17353931
GIT2 CAT-2 | DKFZp686G01261 | KIAA0148 | MGC760 G protein-coupled receptor kinase interacting ArfGAP 2 Affinity Capture-MS BioGRID 17353931
MCM3 HCC5 | MGC1157 | P1-MCM3 | P1.h | RLFB minichromosome maintenance complex component 3 Affinity Capture-MS BioGRID 17353931
MYH10 MGC134913 | MGC134914 | NMMHCB myosin, heavy chain 10, non-muscle Affinity Capture-MS BioGRID 17353931
MYL2 CMH10 | DKFZp779C0562 | MLC2 myosin, light chain 2, regulatory, cardiac, slow - HPRD,BioGRID 10047984
NCK1 MGC12668 | NCK | NCKalpha NCK adaptor protein 1 - HPRD 11160719
PAK2 PAK65 | PAKgamma p21 protein (Cdc42/Rac)-activated kinase 2 hPAK65 autophosphorylates. BIND 9151826
RAC1 MGC111543 | MIG5 | TC-25 | p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) - HPRD,BioGRID 9535855
RAC2 EN-7 | Gx | HSPC022 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) Reconstituted Complex BioGRID 12176041
SH3KBP1 CIN85 | GIG10 | MIG18 SH3-domain kinase binding protein 1 - HPRD,BioGRID 12829691


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129 103 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 36 31 All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY 30 22 All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY 41 30 All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 58 43 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY 29 21 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 67 54 All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 45 37 All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES 35 25 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 62 43 All SZGR 2.0 genes in this pathway
PID MET PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 31 25 All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 70 51 All SZGR 2.0 genes in this pathway
PID MYC PATHWAY 25 22 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 54 37 All SZGR 2.0 genes in this pathway
意图CTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
意图CTOME TCR SIGNALING 54 46 All SZGR 2.0 genes in this pathway
意图CTOME GENERATION OF SECOND MESSENGER MOLECULES 27 25 All SZGR 2.0 genes in this pathway
意图CTOME REGULATION OF APOPTOSIS 58 34 All SZGR 2.0 genes in this pathway
意图CTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
意图CTOME CD28 CO STIMULATION 32 26 All SZGR 2.0 genes in this pathway
意图CTOME ACTIVATION OF RAC 14 11 All SZGR 2.0 genes in this pathway
意图CTOME SEMA3A PAK DEPENDENT AXON REPULSION 15 14 All SZGR 2.0 genes in this pathway
意图CTOME CD28 DEPENDENT VAV1 PATHWAY 11 10 All SZGR 2.0 genes in this pathway
意图CTOME SEMAPHORIN INTERACTIONS 68 53 All SZGR 2.0 genes in this pathway
意图CTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
意图CTOME SIGNALING BY ROBO RECEPTOR 30 26 All SZGR 2.0 genes in this pathway
意图CTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
意图CTOME HIV INFECTION 207 122 All SZGR 2.0 genes in this pathway
意图CTOME HOST INTERACTIONS OF HIV FACTORS 132 81 All SZGR 2.0 genes in this pathway
意图CTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 28 19 All SZGR 2.0 genes in this pathway
意图CTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
意图CTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
意图CTOME APOPTOTIC EXECUTION PHASE 54 37 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
ZERBINI RESPONSE TO SULINDAC UP 9 6 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269 146 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214 134 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 55 40 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP 35 26 All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN 58 43 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 39 26 All SZGR 2.0 genes in this pathway
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP 49 28 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C4 13 10 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 148 96 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS CANCER DN 20 12 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253 192 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR DN 49 33 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-26 351 358 1A,m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-9 829 835 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA