Gene Page:GEMIN4
Summary?
| GeneID | 50628 |
| Symbol | GEMIN4 |
| Synonyms | HC56|HCAP1|HHRF-1|p97 |
| Description | gem nuclear organelle associated protein 4 |
| Reference | MIM:606969|HGNC:HGNC:15717|Ensembl:ENSG00000179409|HPRD:07370|Vega:OTTHUMG00000177495 |
| Gene type | protein-coding |
| Map location | 17p13 |
| Pascal p-value | 0.089 |
| Sherlock p-value | 0.235 |
| Fetal beta | 0.833 |
| DMG | 1 (# studies) |
| eGene | 元 |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 1 |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed的genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0086 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10981541 | 17 | 636487 | GEMIN4 | 1.373E-4 | 3.861 | DMG:vanEijk_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | 新闻学会 | 11714716 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0000387 | spliceosomal snRNP biogenesis | EXP | 15130578 | |
| GO:0006397 | mRNA processing | IEA | - | |
| GO:0008380 | RNA splicing | IEA | - | |
| GO:0006364 | rRNA processing | TAS | 10725331 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 10531003 | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005654 | nucleoplasm | EXP | 10531003 | |
| GO:0005681 | spliceosome | IEA | - | |
| GO:0005730 | nucleolus | TAS | 10725331 | |
| GO:0005737 | cytoplasm | TAS | 10725331 | |
| GO:0030532 | small nuclear ribonucleoprotein complex | TAS | 10725331 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ARS2 | ASR2 | MGC126427 | arsenate resistance protein 2 | HCAP1 interacts with ARS2 | BIND | 12869526 |
| BRF2 | BRFU | FLJ11052 | TFIIIB50 | BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like | Affinity Capture-MS | BioGRID | 17353931 |
| CALCOCO2 | MGC17318 | NDP52 | calcium binding and coiled-coil domain 2 | HCAP1与NDP52 | BIND | 12869526 |
| CDK4 | CMM3 | MGC14458 | PSK-J3 | cyclin-dependent kinase 4 | Affinity Capture-MS | BioGRID | 17353931 |
| DDX20 | DKFZp434H052 | DP103 | GEMIN3 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10725331|11914277 |12668731 |
| DHX9 | DDX9 | LKP | NDHII | RHA | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | Affinity Capture-Western | BioGRID | 11149922 |
| EIF2C2 | AGO2 | MGC3183 | Q10 | eukaryotic translation initiation factor 2C, 2 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11914277|14970384 |
| FBL | FIB | FLRN | RNU3IP1 | fibrillarin | Affinity Capture-Western | BioGRID | 11509230 |
| FIBP | FGFIBP | FIBP-1 | fibroblast growth factor (acidic) intracellular binding protein | Affinity Capture-MS | BioGRID | 17353931 |
| GAR1 | NOLA1 | GAR1 ribonucleoprotein homolog (yeast) | Affinity Capture-Western | BioGRID | 11509230 |
| GEMIN5 | DKFZp586M1824 | MGC142174 | gem (nuclear organelle) associated protein 5 | - | HPRD,BioGRID | 11714716 |
| GEMIN6 | FLJ23459 | gem (nuclear organelle) associated protein 6 | Affinity Capture-Western | BioGRID | 11748230 |
| GIPC1 | C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ domain containing family, member 1 | Affinity Capture-MS | BioGRID | 17353931 |
| GSK3B | - | glycogen synthase kinase 3 beta | Affinity Capture-MS | BioGRID | 17353931 |
| ILK | DKFZp686F1765 | P59 | integrin-linked kinase | Affinity Capture-MS | BioGRID | 17353931 |
| LGALS1 | DKFZp686E23103 | GAL1 | GBP | lectin, galactoside-binding, soluble, 1 | - | HPRD,BioGRID | 11522829 |
| LGALS3 | CBP35 | GAL3 | GALBP | GALIG | LGALS2 | MAC2 | lectin, galactoside-binding, soluble, 3 | - | HPRD,BioGRID | 11522829 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Affinity Capture-MS | BioGRID | 17353931 |
| NFKBIL1 | IKBL | LST1 | NFKBIL | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PIAS3 | FLJ14651 | ZMIZ5 | protein inhibitor of activated STAT, 3 | HCAP1 interacts with PIAS3 | BIND | 12869526 |
| PPP4C | PP4 | PPH3 | PPX | protein phosphatase 4 (formerly X), catalytic subunit | Affinity Capture-Western | BioGRID | 12668731 |
| PPP4R2 | MGC131930 | 蛋白磷酸酶4,regulatory subunit 2 | Affinity Capture-MS Affinity Capture-Western |
BioGRID | 12668731 |
| RNPS1 | E5.1 | MGC117332 | RNA binding protein S1, serine-rich domain | Affinity Capture-MS | BioGRID | 17353931 |
| SMN1 | BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541 | survival of motor neuron 1, telomeric | Affinity Capture-Western Co-fractionation Co-purification |
BioGRID | 10942426|12668731 |
| SNRPB | COD | SNRPB1 | SmB/SmB' | snRNP-B | small nuclear ribonucleoprotein polypeptides B and B1 | Affinity Capture-MS | BioGRID | 17353931 |
| SNRPB | COD | SNRPB1 | SmB/SmB' | snRNP-B | small nuclear ribonucleoprotein polypeptides B and B1 | - | HPRD | 10725331 |
| SPRY1 | hSPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | HCAP1 interacts with SPRY1 | BIND | 12869526 |
| STXBP3 | MUNC18-3 | MUNC18C | PSP | UNC-18C | syntaxin binding protein 3 | - | HPRD | 12065586 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME METABOLISM OF NON CODING RNA | 49 | 29 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS DN | 431 | 263 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW DN | 23 | 15 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER MYC TARGETS AND SERUM RESPONSE UP | 47 | 32 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| SAKAI TUMOR INFILTRATING MONOCYTES DN | 81 | 51 | All SZGR 2.0 genes in this pathway |
| HASLINGER B CLL WITH 17P13 DELETION | 21 | 15 | All SZGR 2.0 genes in this pathway |
| GALE APL WITH FLT3 MUTATED UP | 56 | 35 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| CHEN HOXA5 TARGETS 9HR DN | 41 | 17 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| SMIRNOV RESPONSE TO IR 6HR DN | 114 | 69 | All SZGR 2.0 genes in this pathway |