Gene Page:PAX2

概括?
基因 5076
象征 PAX2
Synonyms FSGS7|PAPRS
Description 配对框2
Reference MIM:167409|HGNC:HGNC:8616|Ensembl:ENSG00000075891|HPRD:01330|Vega:OTTHUMG00000018913
Gene type protein-coding
Map location 10q24
Pascal p-value 0.701
Fetal beta -0.141
DMG 2 (# studies)
eGene Cerebellum

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16443970 10 102504022 PAX2 7.97E-5 -0.334 0.025 DMG:Wockner_2014
cg05622307 10 102490373 PAX2 6.83E-8 -0.014 1.67E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
USP47 0.96 0.97
PHF3 0.96 0.97
AHCTF1 0.96 0.96
ZNF638 0.95 0.97
RBM16 0.95 0.96
SMEK1 0.95 0.96
RSF1 0.95 0.96
TPR 0.95 0.96
NIPBL 0.95 0.97
ZCCHC6 0.95 0.97
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.77 -0.87
IFI27 -0.75 -0.87
MT-CO2 -0.75 -0.86
FXYD1 -0.74 -0.84
HIGD1B -0.74 -0.86
AF347015.27 -0.72 -0.81
AF347015.33 -0.71 -0.80
MT-CYB -0.71 -0.81
AF347015.8 -0.71 -0.83
ENHO -0.70 -0.85

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
GO:0003677 DNA binding TAS 9106533
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0007409 axonogenesis TAS neuron, axon, neurite (GO term level: 12) 9106533
GO：0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
GO:0001657 输尿管芽开发 IEA -
GO:0001709 cell fate determination IEA -
去：0006355 regulation of transcription, DNA-dependent IEA -
GO:0007601 visual perception TAS 9106533
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
GO:0042472 inner ear morphogenesis IEA -
GO:0043010 camera-type eye development IEA -
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
GO:0045449 regulation of transcription IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
去：0005815 微管组织中心 IDA 18000879
GO:0005634 nucleus IEA -
GO:0034451 centriolar satellite IDA 18000879

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391 222 该途径中的所有SZGR 2.0基因
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 该途径中的所有SZGR 2.0基因
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 该途径中的所有SZGR 2.0基因
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 87 48 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
PUJANA CHEK2 PCC NETWORK 779 480 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH PRC2 TARGETS 652 441 该途径中的所有SZGR 2.0基因
SHEPARD CRUSH AND BURN MUTANT DN 185 111 该途径中的所有SZGR 2.0基因
SU PANCREAS 54 30 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR DN 504 323 该途径中的所有SZGR 2.0基因
KONDO PROSTATE CANCER HCP WITH H3K27ME3 97 72 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL DN 701 446 该途径中的所有SZGR 2.0基因
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 50 36 该途径中的所有SZGR 2.0基因
LI WILMS TUMOR 27 12 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K27ME3 269 159 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 1HR DN 222 147 该途径中的所有SZGR 2.0基因
KRIEG HYPOXIA NOT VIA KDM3A 770 480 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 1132 1138 m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-139 1288 1294 1A hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-153 1442 1449 1A,m8 hsa-miR-153 Uugcauagucacaaaaguga
miR-185 1540 1546 m8 hsa-miR-185brain UGGAGAGAAAGGCAGUUC
miR-204/211 1993 1999 1A HSA-MIR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-218 1370 1376 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-329 1188 1194 m8 hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-342 1314 1320 1A HSA-MIR-342brain UCUCACACAGAAAUCGCACCCGUC
mir-365 1395 1401 m8 hsa-miR-365 uaaugccccuaaaaaauccuuau
mir-375 1898 1904 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-448 1443 1449 1A HSA-MIR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-450 1132 1138 1A hsa-miR-450 UUUUUGCGAUGUGUUCCUAAUA