Gene Page:PAX5

概括?
基因 5079
象征 PAX5
Synonyms ALL3|BSAP
Description 配对框5
Reference MIM：167414|HGNC:HGNC:8619|Ensembl:ENSG00000196092|HPRD:01334|Vega:OTTHUMG00000019907
Gene type protein-coding
Map location 9p13
Pascal p-value 1.488E-5
TADA p-value 0.011
Fetal beta 0.061
DMG 1 (# studies)
Support COMPOSITESET

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM：Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur High-throughput literature-search 系统的烤焦ch in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

第一节遗传学和表观遗传学注释

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 筛 CG46 Trait Study
PAX5 chr9 36966706 G A NM_016734 p.207P>L missense 精神分裂症 DNM：Fromer_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14306956 9 37027384 PAX5 1.57E-5 -0.436 0.015 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MCM5 0.95 0.75
CDC45L 0.94 0.68
MCM2 0.94 0.81
DTL 0.94 0.74
TIMELESS 0.94 0.69
CCNB1 0.94 0.79
RAD51 0.94 0.72
AC087645.2 0.94 0.69
BIRC5 0.93 0.69
GINS2 0.93 0.69
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.50 -0.75
AF347015.33 -0.50 -0.75
AF347015.27 -0.50 -0.74
AF347015.31 -0.49 -0.73
MT-CYB -0.49 -0.76
AF347015.8 -0.49 -0.76
AF347015.15 -0.48 -0.76
HLA-F -0.47 -0.63
AF347015.2 -0.46 -0.76
AF347015.26 -0.46 -0.75

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
GO:0003700 transcription factor activity IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 神经系统的发展 IEA neurite (GO term level: 5) -
GO：0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
去：0006355 regulation of transcription, DNA-dependent IEA -
GO:0006366 transcription from RNA polymerase II promoter TAS 10524622
GO:0007283 spermatogenesis IEA -
GO:0009887 organ morphogenesis TAS 10524622
GO:0006959 体液免疫反应 TAS 10524629
GO:0007275 multicellular organismal development IEA -
GO:0007275 multicellular organismal development TAS 10524629
GO:0030154 cell differentiation IEA -
GO:0051573 negative regulation of histone H3-K9 methylation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID CMYB PATHWAY 84 61 该途径中的所有SZGR 2.0基因
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP 59 38 该途径中的所有SZGR 2.0基因
SENGUPTA NASOPHARYNGEAL CARCINOMA DN 349 157 该途径中的所有SZGR 2.0基因
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 该途径中的所有SZGR 2.0基因
PAX FOXO1融合的Davicioni目标 255 177 该途径中的所有SZGR 2.0基因
BOGNI TREATMENT RELATED MYELOID LEUKEMIA UP 30 19 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 该途径中的所有SZGR 2.0基因
RIZ ERYTHROID DIFFERENTIATION 12HR 43 35 该途径中的所有SZGR 2.0基因
KLEIN TARGETS OF BCR ABL1 FUSION 45 34 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
SCHLESINGER METHYLATED DE NOVO IN CANCER 88 64 该途径中的所有SZGR 2.0基因
BENPORATH SUZ12 TARGETS 1038 678 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
SHIN B CELL LYMPHOMA CLUSTER 9 19 13 该途径中的所有SZGR 2.0基因
HADDAD B LYMPHOCYTE PROGENITOR 293 193 该途径中的所有SZGR 2.0基因
ZHAN MULTIPLE MYELOMA CD2 UP 45 32 该途径中的所有SZGR 2.0基因
KUMAR TARGETS OF MLL AF9 FUSION 405 264 该途径中的所有SZGR 2.0基因
MCLACHLAN DENTAL CARIES DN 245 144 该途径中的所有SZGR 2.0基因
在胰腺癌中被甲基化沉默的Sato 1 419 273 该途径中的所有SZGR 2.0基因
MCLACHLAN DENTAL CARIES UP 253 147 该途径中的所有SZGR 2.0基因
HUANG FOXA2 TARGETS UP 45 28 该途径中的所有SZGR 2.0基因
霍克甲基化在癌症 56 45 该途径中的所有SZGR 2.0基因
Smid乳腺癌正常 476 285 该途径中的所有SZGR 2.0基因
GRESHOCK CANCER COPY NUMBER UP 323 240 该途径中的所有SZGR 2.0基因
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 ICP WITH H3K27ME3 74 46 该途径中的所有SZGR 2.0基因
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 该途径中的所有SZGR 2.0基因
MIKKELSEN IPS ICP WITH H3K27ME3 54 32 该途径中的所有SZGR 2.0基因
ZHAN MULTIPLE MYELOMA MS DN 46 24 该途径中的所有SZGR 2.0基因
Mikkelsen ES ICP带有H3K4ME3和H3K27ME3 137 85 该途径中的所有SZGR 2.0基因
MARTENS TRETINOIN RESPONSE UP 857 456 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 该途径中的所有SZGR 2.0基因
Duan PRDM5目标 79 52 该途径中的所有SZGR 2.0基因
LIU TOPBP1 TARGETS 16 8 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
mir-496 383 390 1A,m8 hsa-miR-496 AUUACAUGGCCAAUCUC