Gene Page:PARD6A
概括?
| 基因 | 50855 |
| Symbol | PARD6A |
| Synonyms | PAR-6A|PAR6|PAR6C|PAR6alpha|TAX40|TIP-40 |
| Description | PAR-6家族细胞极性调节器alpha |
| Reference | MIM:607484|HGNC:HGNC:15943|Ensembl:ENSG00000102981|HPRD:06316|Vega:OTTHUMG00000137534 |
| Gene type | protein-coding |
| Map location | 16q22.1 |
| Pascal p-value | 0.011 |
| Sherlock p-value | 0.466 |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
| 去_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | 与神经相关关键字的命中：2 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：0.0447 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26919100 | 16 | 67695516 | PARD6A;ACD | 4.62E-6 | 0.542 | 0.01 | DMG:Wockner_2014 |
| cg08834429 | 16 | 67694862 | ACD;PARD6A | 1.09E-5 | -0.288 | 0.013 | DMG:Wockner_2014 |
| cg04607024 | 16 | 67696204 | PARD6A;ACD | 5.47E-5 | 0.412 | 0.022 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | 去term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去:0008134 | transcription factor binding | TAS | 9482110 | |
| 去:0017048 | Rho GTPase binding | ISS | - | |
| 去:0030742 | GTP-dependent protein binding | ISS | - | |
| Biological process | 去term | Evidence | Neuro keywords | PubMed ID |
| 去:0016032 | viral reproduction | TAS | 9482110 | |
| 去:0007049 | cell cycle | IEA | - | |
| 去:0051301 | cell division | IEA | - | |
| 去:0045217 | cell-cell junction maintenance | ISS | - | |
| Cellular component | 去term | Evidence | Neuro keywords | PubMed ID |
| 去:0042995 | cell projection | IEA | axon (GO term level: 4) | - |
| 去:0005923 | tight junction | ISS | Brain (GO term level: 10) | - |
| 去:0005634 | nucleus | ISS | - | |
| 去:0005737 | cytoplasm | IEA | - | |
| 去：0005938 | cell cortex | IEA | - | |
| 去:0005886 | plasma membrane | IEA | - | |
| 去:0030054 | cell junction | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | Affinity Capture-Western in vitro in vivo Reconstituted Complex 两个杂交 |
BioGRID | 10873802|10934474 |11260256 |
| CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | - | HPRD | 10873802|11260256 |
| CRB3 | - | crumbs homolog 3 (Drosophila) | - | HPRD | 14718572 |
| ECT2 | FLJ10461 | MGC138291 | epithelial cell transforming sequence 2 oncogene | - | HPRD,BioGRID | 15254234 |
| MPP5 | FLJ12615 | PALS1 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | Affinity Capture-Western | BioGRID | 12545177 |
| PARD3 | ASIP | Baz | Bazooka | FLJ21015 | PAR3 | PAR3alpha | PARD3A | SE2-5L16 | SE2-5LT1 | SE2-5T2 | par-3 partitioning defective 3 homolog (C. elegans) | Affinity Capture-Western | BioGRID | 12459187 |
| PLCB1 | FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154 | phospholipase C, beta 1 (phosphoinositide-specific) | PLCB1 (PLC-beta-1) interacts with PARD6A (Par6). This interaction was modeled on a demonstrated interaction between rat PLCB1 and human Par6. | BIND | 15782111 |
| PLCB3 | FLJ37084 | phospholipase C, beta 3 (phosphatidylinositol-specific) | PLCB3 (PLC-beta-3)与PARD6A (Par6) | BIND | 15782111 |
| PRKCI | DXS1179E | MGC26534 | PKCI | nPKC-iota | protein kinase C, iota | 两个杂交 | BioGRID | 16189514 |
| PRKCZ | PKC-ZETA | PKC2 | protein kinase C, zeta | - | HPRD,BioGRID | 11260256 |
| RAC1 | MGC111543 | MIG5 | TC-25 | p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | - | HPRD,BioGRID | 11260256 |
| RHOQ | ARHQ | RASL7A | TC10 | TC10A | ras homolog gene family, member Q | 两个杂交 | BioGRID | 10934474 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ENDOCYTOSIS | 183 | 132 | 该途径中的所有SZGR 2.0基因 |
| KEGG TIGHT JUNCTION | 134 | 86 | 该途径中的所有SZGR 2.0基因 |
| SIG PIP3 SIGNALING IN CARDIAC MYOCTES | 67 | 54 | 该途径中的所有SZGR 2.0基因 |
| SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | 51 | 41 | 该途径中的所有SZGR 2.0基因 |
| PID RHOA PATHWAY | 45 | 33 | 该途径中的所有SZGR 2.0基因 |
| PID INSULIN PATHWAY | 45 | 32 | 该途径中的所有SZGR 2.0基因 |
| PID MET PATHWAY | 80 | 60 | 该途径中的所有SZGR 2.0基因 |
| PID CDC42 PATHWAY | 70 | 51 | 该途径中的所有SZGR 2.0基因 |
| PID NEPHRIN NEPH1 PATHWAY | 31 | 24 | 该途径中的所有SZGR 2.0基因 |
| PID TGFBR PATHWAY | 55 | 38 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CELL CELL COMMUNICATION | 120 | 77 | 该途径中的所有SZGR 2.0基因 |
| REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | 16 | 7 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CELL CELL JUNCTION ORGANIZATION | 56 | 31 | 该途径中的所有SZGR 2.0基因 |
| Reactome紧密连接互动 | 29 | 11 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CELL JUNCTION ORGANIZATION | 78 | 43 | 该途径中的所有SZGR 2.0基因 |
| REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX | 63 | 42 | 该途径中的所有SZGR 2.0基因 |
| HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | 该途径中的所有SZGR 2.0基因 |
| KIM RESPONSE TO TSA AND DECITABINE UP | 129 | 73 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | 该途径中的所有SZGR 2.0基因 |
| WATTEL AUTONOMOUS THYROID ADENOMA UP | 73 | 47 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | 该途径中的所有SZGR 2.0基因 |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | 该途径中的所有SZGR 2.0基因 |
| SWEET KRAS TARGETS DN | 66 | 39 | 该途径中的所有SZGR 2.0基因 |
| MARCINIAK ER STRESS RESPONSE VIA CHOP | 25 | 17 | 该途径中的所有SZGR 2.0基因 |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | 该途径中的所有SZGR 2.0基因 |
| LU EZH2 TARGETS UP | 295 | 155 | 该途径中的所有SZGR 2.0基因 |
| PURBEY TARGETS OF CTBP1 AND SATB1 DN | 180 | 116 | 该途径中的所有SZGR 2.0基因 |
| FOSTER KDM1A TARGETS DN | 211 | 119 | 该途径中的所有SZGR 2.0基因 |