SZGR2 - Beplay体育中心

概括?

基因	51003
象征	MED31
Synonyms	3110004H13Rik\|CGI-125\|Soh1
Description	中介复合体亚基31
参考	HGNC:HGNC:24260\|Ensembl:ENSG00000108590\|HPRD:14382\|Vega：Otthumg00000102051
Gene type	protein-coding
Map location	17p13.1
Pascal p-value	0.13
Fetal beta	-0.162
DMG	1（＃研究）
eGene	Caudate basal ganglia

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1

第一节遗传学和表观遗传学注释

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
CG26623286	17	6555130	MED31	1.84E-8	-0.012	6.57E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因

第四节蛋白质 - 蛋白质相互作用注释

互动者	Aliases B	Official full name B	Experimental	来源	PubMed ID
AES	AES-1 \| AES-2 \| ESP1 \| GRG \| GRG5 \| TLE5	amino-terminal enhancer of split	两个杂交	BioGRID	16169070
AGR2	AG2 \| GOB-4 \| HAG-2 \| XAG-2	anterior gradient homolog 2 (Xenopus laevis)	两个杂交	BioGRID	16169070
ASCC2	ASC1P100	activating signal cointegrator 1 complex subunit 2	两个杂交	BioGRID	16169070
C2orf44	FLJ21945 \| PP384	染色体2开放阅读框44	两个杂交	BioGRID	16169070
C8orf30A	FLJ40907	chromosome 8 open reading frame 30A	两个杂交	BioGRID	16169070
CACNB4	CAB4 \|cacnlb4 \|EA5 \|EJM	calcium channel, voltage-dependent, beta 4 subunit	两个杂交	BioGRID	16169070
CCT7	CCT-ETA \|CCTH \|MGC110985 \|NIP7-1 \|TCP-1-ETA	伴侣素含有TCP1，亚基7（ETA）	两个杂交	BioGRID	16169070
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	亲和力捕获MS	BioGRID	10198638
CPE	-	carboxypeptidase E	两个杂交	BioGRID	16169070
DLEU1	BCMS \| DLB1 \| DLEU2 \| LEU1 \| LEU2 \| MGC22430 \| NCRNA00021 \| XTP6	在淋巴细胞性白血病1（非蛋白质编码）中删除	两个杂交	BioGRID	16169070
DNM1	DNM	dynamin 1	两个杂交	BioGRID	16169070
EEF1G	EF1G \| GIG35	真核翻译伸长因子1伽玛	两个杂交	BioGRID	16169070
EGR2	AT591 \| CMT1D \| CMT4E \| DKFZp686J1957 \| FLJ14547 \| KROX20	early growth response 2 (Krox-20 homolog, Drosophila)	两个杂交	BioGRID	16169070
EPN1	-	epsin 1	两个杂交	BioGRID	16169070
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	两个杂交	BioGRID	16169070
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD	15383276
GSTM4	GSTM4-4 \| GTM4 \| MGC131945 \| MGC9247	glutathione S-transferase mu 4	两个杂交	BioGRID	16169070
HMOX2	HO-2	血红素氧合酶（Deycling）2	两个杂交	BioGRID	16169070
HNRNPUL1	E1B-AP5 \| E1BAP5 \| FLJ12944 \| HNRPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	两个杂交	BioGRID	16169070
HSPB1	CMT2F \| DKFZp586P1322 \| HMN2B \| HS.76067 \| HSP27 \| HSP28 \| Hsp25 \| SRP27	heat shock 27kDa protein 1	两个杂交	BioGRID	16169070
HSPB3	HSPL27	heat shock 27kDa protein 3	两个杂交	BioGRID	16169070
HTT	HD \| IT15	huntingtin	-	HPRD	15383276
喇嘛4	DKFZp686D23145 \| LAMA3 \| LAMA4*-1	层粘连蛋白，α4	两个杂交	BioGRID	16169070
LYPLA2	APT-2 \| DJ886K2.4	lysophospholipase II	两个杂交	BioGRID	16169070
黑手党	MGC13090 \| MGC20149	V-MAF Musculoaponeurototic纤维肉瘤癌基因同源物G（Avian）	两个杂交	BioGRID	16169070
MED10	L6 \|MGC5309 \|nut2 \|TRG20	mediator complex subunit 10	亲和力捕获MS Affinity Capture-Western	BioGRID	14576168\|15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	-	HPRD,BioGRID	12584197
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	亲和力捕获MS	BioGRID	15175163
MED28	1500003d12rik \|DKFZP434N185 \|EG1 \|魔术	mediator complex subunit 28	亲和力捕获MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	-	HPRD,BioGRID	14576168
MED9	FLJ10193 \|Med25 \|MGC138234	mediator complex subunit 9	亲和力捕获MS	BioGRID	15175163
MED9	FLJ10193 \|Med25 \|MGC138234	mediator complex subunit 9	-	HPRD	14638676
mobkl3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	两个杂交	BioGRID	16169070
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	两个杂交	BioGRID	16169070
ORAI2	C7orf19 \|CBCIP2 \|FLJ12474 \|FLJ14733 \|FLJ44818 \|TMEM142B	ORAI calcium release-activated calcium modulator 2	两个杂交	BioGRID	16169070
PABPC4	APP-1 \| APP1 \| FLJ43938 \| PABP4 \| iPABP	保利(A)结合蛋白、胞质4(诱导form)	-	HPRD	15383276
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	两个杂交	BioGRID	16169070
PFDN1	PDF \|PFD1	prefoldin subunit 1	两个杂交	BioGRID	16169070
PMF1	-	polyamine-modulated factor 1	两个杂交	BioGRID	16169070
PQBP1	MRX55 \| MRXS3 \| MRXS8 \| NPW38 \| RENS1 \| SHS	polyglutamine binding protein 1	两个杂交	BioGRID	16169070
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	两个杂交	BioGRID	16169070
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	两个杂交	BioGRID	16169070
RAB25	CATX-8	RAB25, member RAS oncogene family	-	HPRD	11591653
RBM23	Caperbeta \|FLJ10482 \|MGC4458 \|pp239 \|RNPC4	RNA binding motif protein 23	两个杂交	BioGRID	16169070
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	两个杂交	BioGRID	16169070
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	两个杂交	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	精子/精子N1-乙酰转移酶1	两个杂交	BioGRID	16169070
Selenbp1	FLJ13813 \|lpsb \|Sp56 \|HSBP \|HSP56	selenium binding protein 1	两个杂交	BioGRID	16169070
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	两个杂交	BioGRID	16169070
TGIF1	HPE4 \| MGC39747 \| MGC5066 \| TGIF	TGFB诱导的因子同型ox 1	两个杂交	BioGRID	16169070
TINAGL1	ARG1 \| LCN7 \| LIECG3 \| TINAGRP	肾小管间质肾炎抗原样1	两个杂交	BioGRID	16169070
UBE2B	E2-17KDA \|HHR6B \|HR6B \|rad6b \|UBC2	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	两个杂交	BioGRID	16169070
ZBTB45	DKFZp547H249 \| FLJ14486 \| ZNF499	锌指和包含45的BTB域	两个杂交	BioGRID	16169070

V.途径注释

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DEVELOPMENTAL BIOLOGY	396	292	该途径中的所有SZGR 2.0基因
Reactome Ppara激活基因表达	104	72	该途径中的所有SZGR 2.0基因
Reactome通用转录途径	352	181	该途径中的所有SZGR 2.0基因
脂质和脂蛋白的反应组代谢	478	302	该途径中的所有SZGR 2.0基因
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	该途径中的所有SZGR 2.0基因
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	该途径中的所有SZGR 2.0基因
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS	1062	725	该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3	1118	744	该途径中的所有SZGR 2.0基因
BENPORATH CYCLING GENES	648	385	该途径中的所有SZGR 2.0基因
CARDOSO RESPONSE TO GAMMA RADIATION AND 3AB	18	11	该途径中的所有SZGR 2.0基因
BILD CTNNB1 ONCOGENIC SIGNATURE	82	52	该途径中的所有SZGR 2.0基因
WHITFIELD CELL CYCLE G1 S	147	76	该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 1 DN	63	39	该途径中的所有SZGR 2.0基因

Gene Page:MED31