Gene Page:POLR1D

Summary?
GeneID 51082
Symbol POLR1D
Synonyms AC19|POLR1C|RPA16|RPA9|RPAC2|RPC16|RPO1-3|TCS2
Description polymerase (RNA) I subunit D
Reference MIM:613715|HGNC:HGNC:20422|Ensembl:ENSG00000186184|HPRD:14717|HPRD:17877|Vega:OTTHUMG00000016635
Gene type protein-coding
Map location 13q12.2
Pascal p-value 0.12
Sherlock p-value 0.481
Fetal beta 1.372
DMG 1 (# studies)
eGene Caudate basal ganglia
Cerebellum
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06611744 13 27844618 POLR1D 0.002 -4.247 DMG:vanEijk_2014
cg06611744 13 27844618 POLR1D 7.004E-4 -7.32 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 POLR1D 51082 0 trans
rs9461864 chr6 33481468 POLR1D 51082 0.17 trans
rs3118341 chr9 25185518 POLR1D 51082 0.08 trans
rs16955618 chr15 29937543 POLR1D 51082 1.072E-6 trans
rs299937 chr16 86694309 POLR1D 51082 0.15 trans
rs1041786 chr21 22617710 POLR1D 51082 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception我们eks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
GO:0003899 DNA-directed RNA polymerase activity IEA -
GO:0046983 protein dimerization activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006350 transcription IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm 经验值 9582279|12393749|12646563

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
KEGG PYRIMIDINE METABOLISM 98 53 All SZGR 2.0 genes in this pathway
KEGG RNA POLYMERASE 29 12 All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 56 44 All SZGR 2.0 genes in this pathway
BIOCARTA ARF PATHWAY 17 13 All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER 23 12 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION TERMINATION 22 12 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 89 64 All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION 33 18 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210 127 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 122 80 All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER 26 13 All SZGR 2.0 genes in this pathway
REACTOME RNA POL III TRANSCRIPTION TERMINATION 19 10 All SZGR 2.0 genes in this pathway
REACTOME RNA POL III CHAIN ELONGATION 17 8 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION 25 14 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA HP UP 49 26 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 69 41 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222 139 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS DN 54 38 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS DN 46 24 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 92 60 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208 107 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-224 97 103 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA