SZGR2 - Beplay体育中心

Summary?

GeneID	5111
象征	PCNA
Synonyms	ATLD2
Description	增殖细胞核抗原
Reference	MIM:176740\|HGNC:HGNC:8729\|ENSEMBL：ENSG00000132646\|HPRD:01456\|Vega:OTTHUMG00000031798
基因类型	protein-coding
Map location	20pter-p12
Pascal p-value	0.388
Sherlock p-value	0.653
Fetal beta	2.024
eGene	Cerebellar Hemisphere Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	点击to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0044

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs1578978	CHR8	118196802	PCNA	5111		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
C1orf183	0.88	0.79
PITPNM2	0.86	0.75
KIAA1045	0.86	0.76
IQSEC2	0.85	0.79
PITPNM3	0.85	0.83
Garnl4	0.85	0.70
NOS2	0.85	0.74
TMEM132D	0.84	0.77
LRRK1	0.84	0.81
CTSB	0.84	0.74

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
BCL7C	-0.47	-0.61
HEBP2	-0.47	-0.66
RPS6	-0.46	-0.60
RPL23A	-0.45	-0.59
RPL18	-0.45	-0.62
RPS19P3	-0.45	-0.62
C9orf46	-0.45	-0.55
RPS3P3	-0.44	-0.57
RPL19P12	-0.44	-0.57
RPL32	-0.44	-0.57

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
去：0003677	DNA binding	IEA		-
GO:0005515	protein binding	IPI		9305916\|15225546\|15358233
GO：0032405	MutLalpha complex binding	IDA		11005803
GO:0030337	DNA polymerase processivity factor activity	IEA		-
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
去：0006297	nucleotide-excision repair, DNA gap filling	经验		9111189
去：0006287	base-excision repair, gap-filling	IEA		-
去：0006281	DNA repair	nas		15504738
GO:0006275	regulation of DNA replication	IEA		-
GO:0008283	cell proliferation	TAS		2565339
GO:0048015	phosphoinositide-mediated signaling	nas		15504738
GO:0006886	intracellular protein transport	IEA		-
Cellular component	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0000307	细胞周期蛋白依赖性蛋白激酶全酶复合物	IEA		-
GO:0005634	nucleus	IEA		-
去：0005652	nuclear lamina	IEA		-
去：0005654	核质	经验		9822671\|11473323
去：0005663	DNA replication factor C complex	TAS		2565339
GO:0043626	PCNA complex	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	Experimental	Source	PubMed ID
anxa2	Anx2 \|Anx2l4 \|cal1h \|lip2 \|LPC2 \|LPC2D \|p36 \|PAP-IV	annexin A2	-	HPRD,BioGRID	9228079\|12171929
APEX1	猿\|ape-1 \|APE1 \|apen \|顶点\|APX \|hap1 \|ref-1 \|参考文献1	顶点核酸酶（多功能DNA修复酶）1	-	HPRD,BioGRID	11601988
APEX2	APE2 \| APEXL2 \| XTH2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	-	HPRD,BioGRID	11376153
APEX2	APE2 \| APEXL2 \| XTH2	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	APE2 is a PCNA-binding protein	BIND	11376153
BAZ1B	WBSCR10 \| WBSCR9 \| WSTF	bromodomain adjacent to zinc finger domain, 1B	PCNA interacts with WSTF	BIND	15543136
CCNA2	CCN1 \| CCNA	cyclin A2	Affinity Capture-Western	BioGRID	12853968
CCNB1	CCNB	细胞周期蛋白B1	-	HPRD,BioGRID	8101826
CCND1	bcl1 \|D11S287E \|prad1 \|U21B31	cyclin D1	Reconstituted Complex	BioGRID	7908906
CCND3	-	cyclin D3	-	HPRD,BioGRID	7908906
CCNO	CCNU \| FLJ22422 \| UDG2 \| UNG2	cyclin O	-	HPRD,BioGRID	10393198\|12171929
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	7949095
CDC25C	CDC25	细胞分裂周期25同源C（S。Pombe）	-	HPRD,BioGRID	11896603
CDC6	CDC18L \| HsCDC18 \| HsCDC6	cell division cycle 6 homolog (S. cerevisiae)	-	HPRD,BioGRID	9566895
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD,BioGRID	10930425
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	Affinity Capture-Western	BioGRID	8259215
CDK5	PSSALRE	cyclin-dependent kinase 5	-	HPRD	7949095
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	-	HPRD	9667749
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A(p21) interacts with PCNA.	BIND	8662825
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21WAF1 interacts with PCNA.	BIND	7780738
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	PCNA interacts with p21.	BIND	9705499
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	PCNA interacts with p21.	BIND	9178907
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	P21与PCNA相互作用。	BIND	11302688
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	PCNA interacts with p21.	BIND	8861969
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	P21与PCNA相互作用。	BIND	9632134
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	P21与PCNA相互作用。This interaction was modeled on a demonstrated interaction between human p21 and PCNA from an unspecified species.	BIND	9546435
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	8861913
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21WAF1 interacts with PCNA. This interaction was modeled on a demonstrated interaction between human p21WAF1 and Pisum sativum v. Onward PCNA.	BIND	8647134
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	P21与PCNA相互作用。This interaction was modeled on a demonstrated interaction between human p21 and hamster PCNA.	BIND	9467962
CDKN1C	BWCR \|BWS \|kip2 \|WBS \|p57	细胞周期蛋白依赖性激酶抑制剂1C（P57，KIP2）	-	HPRD,BioGRID	9465025
CHAF1A	CAF-1 \| CAF1 \| CAF1B \| CAF1P150 \| MGC71229 \| P150	chromatin assembly factor 1, subunit A (p150)	-	HPRD,BioGRID	10648606
CHTF18	C16orf41 \| C321D2.2 \| C321D2.3 \| C321D2.4 \| CHL12 \| Ctf18 \| RUVBL	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	-	HPRD	12766176
CHTF18	C16orf41 \| C321D2.2 \| C321D2.3 \| C321D2.4 \| CHL12 \| Ctf18 \| RUVBL	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	-	HPRD,BioGRID	12171929
CTF8	DERPC \| FLJ20400	chromosome transmission fidelity factor 8 homolog (S. cerevisiae)	-	HPRD	12766176
DDX17	DKFZP761H2016 \|P72 \|RH70	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	DDX17 is a PCNA-binding protein	BIND	12171929
DHX9	DDX9 \| LKP \| NDHII \| RHA	DEAH（ASP-GLU-ALA-HIS）盒多肽9	-	HPRD	12171929
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9302295\|10888872 \|12354094
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	DNMT1是PCNA结合蛋白	BIND	12171929
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	-	HPRD	9302295\|12354094
DNTT	TDT	脱氧核苷酸转移酶，末端	Co-purification Reconstituted Complex Two-hybrid	BioGRID	11554927
DNTTIP2	ERBP \| FCF2 \| HSU15552 \| LPTS-RP2 \| MGC163494 \| RP4-561L24.1 \| TdIF2	脱氧核苷酸转移酶，末端, interacting protein 2	-	HPRD	12786946
DSCC1	DCC1 \| MGC5528 \| hDCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	-	HPRD	12766176
DSCC1	DCC1 \| MGC5528 \| hDCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	Hypothetical protein MGC5528 is a PCNA-binding protein.	BIND	12171929
EP300	kat3b \|P300	E1A binding protein p300	-	HPRD,BioGRID	11268218
ERCC5	COFS3 \|ERCM2 \|uvdr \|XPG \|XPGC	excision repair cross-complementing rodent repair deficiency, complementation group 5	-	HPRD,BioGRID	9305916\|10408173
EXO1	hex1 \|hexoi	exonuclease 1	PCNA interacts with EXO1b.	BIND	15225546
FEN1	fen-1 \|MF1 \|rad2	flap structure-specific endonuclease 1	PCNA与FEN1相互作用。这种相互作用是基于未指定物种的人PCNA和FEN1之间的相互作用进行建模的。	BIND	9705499
FEN1	fen-1 \|MF1 \|rad2	flap structure-specific endonuclease 1	PCNA与FEN1相互作用。	BIND	9178907
FEN1	fen-1 \|MF1 \|rad2	flap structure-specific endonuclease 1	Affinity Capture-Western Co-purification Reconstituted Complex Two-hybrid	BioGRID	8876181\|9305916 \|9545252\|11430825 \|11601988\|12853968
FEN1	fen-1 \|MF1 \|rad2	flap structure-specific endonuclease 1	FEN1 is a PCNA-binding protein	BIND	12171929
FEN1	fen-1 \|MF1 \|rad2	flap structure-specific endonuclease 1	-	HPRD	1477073\|8876181 \|9305916\|9545252 \|11430825
GADD45A	ddit1 \|GADD45	生长停滞和DNA损伤诱导的α	PCNA与GADD45相互作用。	BIND	9705499
GADD45A	ddit1 \|GADD45	生长停滞和DNA损伤诱导的α	PCNA与GADD45相互作用。	BIND	9178907
GADD45A	ddit1 \|GADD45	生长停滞和DNA损伤诱导的α	Gadd45a interacts with PCNA. This interaction was modeled on a demonstrated interaction between Gadd45a from an unspecified species and human PCNA.	BIND	12124778
GADD45A	ddit1 \|GADD45	生长停滞和DNA损伤诱导的α	-	HPRD,BioGRID	7973727\|10828065
GADD45A	ddit1 \|GADD45	生长停滞和DNA损伤诱导的α	GADD45interacts with PCNA.	BIND	10828065
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	生长停滞和DNA损伤诱导，beta	-	HPRD	10828065
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	生长停滞和DNA损伤诱导，beta	MyD118与PCNA相互作用。	BIND	10828065
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	生长停滞和DNA损伤诱导，beta	GADD45B与PCNA相互作用。这种相互作用是根据未指定物种和人PCNA的GADD45B之间的相互作用进行建模的。	BIND	12124778
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	GADD45G与PCNA相互作用。这种相互作用是基于未指定物种和人PCNA的GADD45G之间的相互作用进行建模的。	BIND	12124778
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD,BioGRID	10455148\|11022036
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	11929879
HUS1	-	HUS1检查点同源物（S. Pombe）	-	HPRD,BioGRID	11077446
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	-	HPRD,BioGRID	11682605\|12015309
KCTD13	FKSG86 \| PDIP1 \| POLDIP1	potassium channel tetramerisation domain containing 13	C terminus of PDIP1 interacts with PCNA.	BIND	11593007
KCTD13	FKSG86 \| PDIP1 \| POLDIP1	potassium channel tetramerisation domain containing 13	-	HPRD,BioGRID	11593007
LIG1	MGC117397 \| MGC130025	ligase I, DNA, ATP-dependent	-	HPRD,BioGRID	12171929
LIG1	MGC117397 \| MGC130025	ligase I, DNA, ATP-dependent	LIG1 is a PCNA-binding protein	BIND	12171929
MCL1	BCL2L3 \| EAT \| MCL1L \| MCL1S \| MGC104264 \| MGC1839 \| TM	髓样细胞白血病序列1（与BCL2相关）	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10978339
MSH2	COCA1 \| FCC1 \| HNPCC \| HNPCC1 \| LCFS2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	-	HPRD,BioGRID	8858149\|12171929
MSH3	DUP \| MGC163306 \| MGC163308 \| MRP1	mutS homolog 3 (E. coli)	MSH3 is a PCNA-binding protein	BIND	12171929
MSH3	DUP \| MGC163306 \| MGC163308 \| MRP1	mutS homolog 3 (E. coli)	-	HPRD,BioGRID	11005803\|11274057 \|12171929
MSH6	GTBP \| HNPCC5 \| HSAP	mutS homolog 6 (E. coli)	-	HPRD	11005803\|12171929
MSH6	GTBP \| HNPCC5 \| HSAP	mutS homolog 6 (E. coli)	Affinity Capture-MS Affinity Capture-Western Far Western 蛋白质肽	BioGRID	11005803\|11274057 \|12171929
MSH6	GTBP \| HNPCC5 \| HSAP	mutS homolog 6 (E. coli)	MSH6 is a PCNA-binding protein	BIND	12171929
MUTYH	MGC4416 \| MYH	mutY homolog (E. coli)	-	HPRD,BioGRID	11092888
MUTYH	MGC4416 \| MYH	mutY homolog (E. coli)	hMYH is associated in vivo with proliferating cell nuclear antigen (PCNA)	BIND	11092888
MYBBP1A	FLJ37886 \|P160 \|pap2	MYB binding protein (P160) 1a	-	HPRD,BioGRID	12171929
MYBBP1A	FLJ37886 \|P160 \|pap2	MYB binding protein (P160) 1a	MYBBP1A is a PCNA-binding protein	BIND	12171929
NONO	NMT55 \|NRB54 \|p54 \|p54nrb	non-POU domain containing, octamer-binding	NONO is a PCNA-binding protein	BIND	12171929
PARP1	adprt \|adprt1 \|PARP \|PARP-1 \|ppol \|PADPRT-1	poly (ADP-ribose) polymerase 1	Affinity Capture-Western	BioGRID	12930846
PCNA	MGC8367	增殖细胞核抗原	Co-purification	BioGRID	9545252
PCNA	MGC8367	增殖细胞核抗原	PCNA interacts with PCNA.	BIND	10858286
POLB	MGC125976	DNA聚合酶(流转d), beta	Mammalian DNA beta-polymerase and PCNA can form a complex both in vitro and in vivo	BIND	12063248
POLD1	CDC2\| POLD	聚合酶（导向DNA），三角洲1，催化亚基125KDA	POLD1 is a PCNA-binding protein	BIND	12171929
POLD1	CDC2\| POLD	聚合酶（导向DNA），三角洲1，催化亚基125KDA	-	HPRD,BioGRID	9563011
POLD2	-	DNA聚合酶(流转d), delta 2, regulatory subunit 50kDa	PCNA interacts with the small subunit of DNA polymerase delta	BIND	11986310
POLD2	-	DNA聚合酶(流转d), delta 2, regulatory subunit 50kDa	-	HPRD	11986310\|12171929
POLD2	-	DNA聚合酶(流转d), delta 2, regulatory subunit 50kDa	-	HPRD,BioGRID	11986310
POLD3	KIAA0039 \|MGC119642 \|MGC119643 \|p66 \|P68	polymerase (DNA-directed), delta 3, accessory subunit	KIAA0039 is a PCNA-binding protein	BIND	12171929
POLD3	KIAA0039 \|MGC119642 \|MGC119643 \|p66 \|P68	polymerase (DNA-directed), delta 3, accessory subunit	-	HPRD	10219083
POLD3	KIAA0039 \|MGC119642 \|MGC119643 \|p66 \|P68	polymerase (DNA-directed), delta 3, accessory subunit	-	HPRD,BioGRID	11595739\|12171929
POLDIP2	DKFZP586F1524 \|PDIP38 \|pold4	聚合酶（DNA定向），Delta相互作用蛋白2	-	HPRD,BioGRID	12522211
POLDIP2	DKFZP586F1524 \|PDIP38 \|pold4	聚合酶（DNA定向），Delta相互作用蛋白2	PDIP38 interacts with PCNA.	BIND	12522211
POLE	DKFZp434F222 \| FLJ21434 \| POLE1	DNA聚合酶(流转d), epsilon	-	HPRD,BioGRID	12171929
POLE	DKFZp434F222 \| FLJ21434 \| POLE1	DNA聚合酶(流转d), epsilon	极是PCNA结合蛋白	BIND	12171929
POLH	FLJ16395 \|FLJ21978 \|rad30 \|rad30a \|XP-V \|XPV	DNA聚合酶(流转d), eta	-	HPRD,BioGRID	11585903
POLL	BETA-N \| FLJ46002 \| POL-KAPPA	DNA聚合酶(流转d), lambda	-	HPRD,BioGRID	12368291
POLM	Tdt-N	聚合酶（定向DNA），MU	-	HPRD	11724965
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	-	HPRD,BioGRID	12171929
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	PRKDC is a PCNA-binding protein	BIND	12171929
PTMA	MGC104802 \| TMSA	螺赛蛋白，α	-	HPRD	11310559
rad9a	RAD9	RAD9同源物A（S。Pombe）	-	HPRD	11994305
RFC1	A1 \| MGC51786 \| MHCBFB \| PO-GA \| RECC1 \| RFC \| RFC140	replication factor C (activator 1) 1, 145kDa	-	HPRD	8861969\|12045192 \|12171929
RFC1	A1 \| MGC51786 \| MHCBFB \| PO-GA \| RECC1 \| RFC \| RFC140	replication factor C (activator 1) 1, 145kDa	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	8861969\|8999859 \|10353443\|12171929 \|12192049
RFC2	A1 \| MGC3665 \| RFC40	replication factor C (activator 1) 2, 40kDa	RFC2是PCNA结合蛋白	BIND	12171929
RFC2	A1 \| MGC3665 \| RFC40	replication factor C (activator 1) 2, 40kDa	Affinity Capture-MS Reconstituted Complex	BioGRID	8093561\|9228079 \|12171929
RFC2	A1 \| MGC3665 \| RFC40	replication factor C (activator 1) 2, 40kDa	-	HPRD	1313560\|9228079 \|10051561\|12171929
RFC3	MGC5276 \| RFC38	replication factor C (activator 1) 3, 38kDa	-	HPRD	10051561\|12171929
RFC3	MGC5276 \| RFC38	replication factor C (activator 1) 3, 38kDa	RFC3is a PCNA-binding protein	BIND	12171929
RFC3	MGC5276 \| RFC38	replication factor C (activator 1) 3, 38kDa	Affinity Capture-MS Affinity Capture-Western	BioGRID	12171929\|12766176
RFC4	A1 \| MGC27291 \| RFC37	replication factor C (activator 1) 4, 37kDa	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	9228079\|12171929
RFC4	A1 \| MGC27291 \| RFC37	replication factor C (activator 1) 4, 37kDa	-	HPRD	10051561\|12171929
RFC5	MGC1155 \| RFC36	复制因子C（激活剂1）5，36.5KDA	RFC5is a PCNA-binding protein	BIND	12171929
RFC5	MGC1155 \| RFC36	复制因子C（激活剂1）5，36.5KDA	Affinity Capture-MS Reconstituted Complex	BioGRID	8999859\|9228079 \|12171929
RFC5	MGC1155 \| RFC36	复制因子C（激活剂1）5，36.5KDA	-	HPRD	8999859\|9751713 \|12171929\|12237462
RPA1	HSSB \| REPA1 \| RF-A \| RP-A \| RPA70	replication protein A1, 70kDa	-	HPRD,BioGRID	12171929
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	Affinity Capture-MS	BioGRID	12171929
SUB1	MGC102747 \| P15 \| PC4 \| p14	Sub1同源物（S. cerevisiae）	Two-hybrid	BioGRID	11313979
TCOF1	MFD1 \| treacle	背叛者Collins-Franceschetti综合征1	TCOF1是PCNA结合蛋白	BIND	12171929
UNG	DGU \| DKFZp781L1143 \| HIGM4 \| UDG \| UNG1 \| UNG15 \| UNG2	uracil-DNA glycosylase	UNG is a PCNA-binding protein	BIND	12171929
WRN	DKFZp686C2056 \| RECQ3 \| RECQL2 \| RECQL3	Werner syndrome	-	HPRD,BioGRID	10871373\|12633936
XRCC1	RCC	X射线修复补充中国仓鼠细胞中有缺陷的修复1	Affinity Capture-Western 共定位烦恼 Reconstituted Complex	BioGRID	15107487
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	-	HPRD,BioGRID	12393188
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X射线修复补充中国仓鼠细胞中有缺陷的修复6	-	HPRD,BioGRID	11239001\|12171929
YBX1	BP-8 \| CSDA2 \| CSDB \| DBPB \| MDR-NF1 \| MGC104858 \| MGC110976 \| MGC117250 \| NSEP-1 \| NSEP1 \| YB-1 \| YB1	Y盒结合蛋白1	-	HPRD,BioGRID	9927044

Section V. Pathway annotation

路径名	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG DNA REPLICATION	36	21	All SZGR 2.0 genes in this pathway
KEGG BASE EXCISION REPAIR	35	22	All SZGR 2.0 genes in this pathway
KEGG NUCLEOTIDE EXCISION REPAIR	44	25	All SZGR 2.0 genes in this pathway
KEGG不匹配维修	23	14	All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY	16	13	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY	65	37	All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY	29	19	All SZGR 2.0 genes in this pathway
Reactome碱基切除修复	19	13	All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1	25	13	All SZGR 2.0 genes in this pathway
REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	17	11	All SZGR 2.0 genes in this pathway
反应组细胞周期	421	253	All SZGR 2.0 genes in this pathway
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	15	10	All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC	325	185	All SZGR 2.0 genes in this pathway
Reactome转录耦合ner tc ner	45	24	All SZGR 2.0 genes in this pathway
Reactome G1 S过渡	112	63	All SZGR 2.0 genes in this pathway
REACTOME POL SWITCHING	13	9	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR	51	27	All SZGR 2.0 genes in this pathway
REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	14	11	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相	137	79	All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR	112	59	All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE	122	80	All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER	35	20	All SZGR 2.0 genes in this pathway
REACTOME LAGGING STRAND SYNTHESIS	19	12	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	35	17	All SZGR 2.0 genes in this pathway
Reactome G1的特定转录	19	9	All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE	75	57	All SZGR 2.0 genes in this pathway
REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	10	8	All SZGR 2.0 genes in this pathway
REACTOME EXTENSION OF TELOMERES	27	17	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION	30	18	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN	87	49	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
Johansson神经胶质作用是PDGFB	58	44	All SZGR 2.0 genes in this pathway
奥尔森E2F3 DN的目标	49	33	All SZGR 2.0 genes in this pathway
TP53和TP63的Schavolt目标	16	12	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
罗斯蒂宫颈癌增殖簇	140	73	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE	105	68	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED DN	5	5	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP	61	25	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCIAN反转TP53和TP73的目标	11	9	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP	34	23	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath Myc Max目标	775	494	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
Benporath增殖	147	80	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA DN	54	34	All SZGR 2.0 genes in this pathway
MORI不成熟的B淋巴细胞DN	90	55	All SZGR 2.0 genes in this pathway
考夫曼DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
考夫曼DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS UP	58	40	All SZGR 2.0 genes in this pathway
LIN APC目标	77	55	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN	87	69	All SZGR 2.0 genes in this pathway
REN BOUND BY E2F	61	40	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP	42	26	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN	87	57	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP	70	47	All SZGR 2.0 genes in this pathway
Yagi AML Fab标记	191	131	All SZGR 2.0 genes in this pathway
Iglesias E2F目标	151	103	All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS	41	26	All SZGR 2.0 genes in this pathway
zamora nos2靶向	69	41	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER HEREDITARY VS SPORADIC	50	32	All SZGR 2.0 genes in this pathway
Lee Calorie限制性新皮层	83	66	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
江VHL目标	138	91	All SZGR 2.0 genes in this pathway
Mahajan对IL1A DN的反应	76	57	All SZGR 2.0 genes in this pathway
INGA TP53目标	17	13	All SZGR 2.0 genes in this pathway
Rhodes未分化的癌症	69	44	All SZGR 2.0 genes in this pathway
Maclachlan BRCA1靶向	21	16	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3	101	64	All SZGR 2.0 genes in this pathway
Sesto对UV C0的反应	107	72	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL	42	33	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
KALMA E2F1目标	11	7	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS DN	17	10	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE SULINDAC 6	52	32	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE	246	153	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
Hillion HMGA1目标	90	71	All SZGR 2.0 genes in this pathway
Hillion HMGA1B目标	92	68	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP	77	47	All SZGR 2.0 genes in this pathway
斯坦ESRRA TARGETS RESPONSIVE TO ESTROGEN DN	41	26	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS	116	63	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP	112	71	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP	111	69	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
MARSHALL VIRAL INFECTION RESPONSE DN	29	21	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
Croonquist IL6剥夺DN	98	69	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
Ishida E2F目标	53	27	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP	62	42	All SZGR 2.0 genes in this pathway
斯坦ESR1 TARGETS	85	55	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
winnepenninckx黑色素瘤转移	162	86	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP	93	62	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE	44	25	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S	147	76	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
马滕斯三维诺蛋白响应DN	841	431	All SZGR 2.0 genes in this pathway
Chicas RB1靶向衰老	572	352	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应6小时	229	149	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应24小时	324	193	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 DN	48	30	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE	227	151	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY	47	23	All SZGR 2.0 genes in this pathway
24小时IR响应中的周细胞周期基因	128	73	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	miRNA seq
mirna家族	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-217	273	279	M8	hsa-miR-217	uacugcaucagaacugauuggau

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击hereto see the list of brain related miRNAs.

Gene Page:PCNA