Gene Page:SAR1B

概括?
基因 51128
象征 SAR1B
Synonyms ANDD|CMRD|GTBPB|SARA2
Description secretion associated Ras related GTPase 1B
Reference MIM:607690|HGNC:HGNC:10535|ENSEMBL：ENSG00000152700|HPRD:09647|Vega:OTTHUMG00000129114
Gene type protein-coding
Map location 5Q31.1
Pascal p-value 0.09
Sherlock p-value 0.068
Fetal beta -0.245
DMG 1 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_I Genome scan meta-analysis Psr: 0.0032

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg10441365 5 133968626 SAR1B 5.89E-8 -0.018 1.49E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IEA -
GO:0005525 GTP binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO：0016044 膜组织 经验 11031247
GO:0007264 small GTPase mediated signal transduction IEA -
GO:0006886 intracellular protein transport IEA -
GO:0006888 ER到高尔基体介导的运输 经验 11252894
GO:0016192 囊泡介导的运输 IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005794 Golgi apparatus IEA -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005622 intracellular IEA -
GO:0005783 endoplasmic reticulum IEA -
去：0016020 membrane IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME MEMBRANE TRAFFICKING 129 74 该途径中的所有SZGR 2.0基因
REACTOME MHC CLASS II ANTIGEN PRESENTATION 91 61 该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF PROTEINS 518 242 该途径中的所有SZGR 2.0基因
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188 116 该途径中的所有SZGR 2.0基因
脂质和脂蛋白的反应组代谢 478 302 该途径中的所有SZGR 2.0基因
Reactome天冬酰胺N连接的糖基化 81 54 该途径中的所有SZGR 2.0基因
REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION 33 24 该途径中的所有SZGR 2.0基因
Reactome脂质消化和运输 46 37 该途径中的所有SZGR 2.0基因
REACTOME LIPOPROTEIN METABOLISM 28 24 该途径中的所有SZGR 2.0基因
REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT 16 15 该途径中的所有SZGR 2.0基因
REACTOME IMMUNE SYSTEM 933 616 该途径中的所有SZGR 2.0基因
REACTOME适应性免疫系统 539 350 该途径中的所有SZGR 2.0基因
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 21 17 该途径中的所有SZGR 2.0基因
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 该途径中的所有SZGR 2.0基因
ONKEN UVEAL MELANOMA UP 783 507 该途径中的所有SZGR 2.0基因
turashvili乳房小叶癌与小叶正常DN 74 42 该途径中的所有SZGR 2.0基因
BASAKI YBX1 TARGETS UP 290 177 该途径中的所有SZGR 2.0基因
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 该途径中的所有SZGR 2.0基因
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 该途径中的所有SZGR 2.0基因
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 该途径中的所有SZGR 2.0基因
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 该途径中的所有SZGR 2.0基因
MANALO HYPOXIA DN 289 166 该途径中的所有SZGR 2.0基因
DOUGLAS BMI1 TARGETS UP 566 371 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 该途径中的所有SZGR 2.0基因
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性3 720 440 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性5 482 296 该途径中的所有SZGR 2.0基因
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP 64 40 该途径中的所有SZGR 2.0基因
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 该途径中的所有SZGR 2.0基因
BOCHKIS FOXA2 TARGETS 425 261 该途径中的所有SZGR 2.0基因
MOOTHA PGC 420 269 该途径中的所有SZGR 2.0基因
CHANG CORE SERUM RESPONSE UP 212 128 该途径中的所有SZGR 2.0基因
肌肉中的罗马胰岛素靶标 442 263 该途径中的所有SZGR 2.0基因
王复发性肝癌DN 16 9 该途径中的所有SZGR 2.0基因
YOSHIOKA LIVER CANCER EARLY RECURRENCE DN 65 31 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-153 480 486 1A hsa-miR-153 Uugcauagucacaaaaguga
miR-17-5p/20/93.mr/106/519.d 294 300 m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
mir-25/32/92/363/367 493 499 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 Aauugcacuuuagcaaugga
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-26 71 77 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-448 480 486 1A HSA-MIR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-452 482 488 m8 hsa-miR-452 UguuugcaggaaacugagaC
miR-93.hd/291-3p/294/295/302/372/373/520 293 299 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU