Gene Page:PCSK2

Summary?
GeneID 5126
Symbol PCSK2
Synonyms NEC 2|NEC-2|NEC2|PC2|SPC2
Description proprotein convertase subtilisin/kexin type 2
Reference MIM:162151|HGNC:HGNC:8744|Ensembl:ENSG00000125851|HPRD:01202|Vega:OTTHUMG00000031941
Gene type protein-coding
Map location 20p11.2
Pascal p-value 0.087
Sherlock p-value 0.728
Fetal beta -2.396
DMG 1 (# studies)
Support NEUROTROPHIN SIGNALING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_I Genome scan meta-analysis Psr: 0.046
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02706653 20 17208584 PCSK2 7.21E-10 -0.022 9.89E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TJAP1 0.78 0.79
DNHD1 0.77 0.80
PHLDB1 0.72 0.70
KIAA1755 0.71 0.62
TBC1D2 0.70 0.72
PLEKHG3 0.69 0.64
SLC45A3 0.68 0.68
CC2D1B 0.68 0.71
MYO15B 0.68 0.66
MYO15B 0.67 0.69
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CARD16 -0.37 -0.35
CAPZA2 -0.36 -0.36
BRP44 -0.36 -0.40
SNX3 -0.34 -0.33
NGB -0.34 -0.36
COMMD7 -0.34 -0.35
GPR160 -0.34 -0.38
PPEF1 -0.32 -0.24
B4GALT2 -0.32 -0.30
NPPA -0.31 -0.31

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0005515 protein binding 新闻学会 7913882
GO:0008233 peptidase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development IEA neurite (GO term level: 5) -
GO:0006508 proteolysis IEA -
GO:0034230 enkephalin processing ISS -
GO:0034231 islet amyloid polypeptide processing ISS -
GO:0016540 protein autoprocessing IEA -
GO:0030070 insulin processing IDA 7626024
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005615 extracellular space IDA 9020868
GO:0005625 soluble fraction IDA 8034613
GO:0016020 membrane IDA 8034613
GO:0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
REACTOME INSULIN SYNTHESIS AND PROCESSING 21 15 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP 73 47 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN 39 30 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
MASRI RESISTANCE TO TAMOXIFEN AND AROMATASE INHIBITORS DN 20 11 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163 100 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210 148 All SZGR 2.0 genes in this pathway
ROLEF GLIS3 TARGETS 37 29 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-138 706 712 m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-200bc/429 2288 2295 1A,m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-203.1 1760 1766 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-299-5p 1711 1717 1A hsa-miR-299-5p UGGUUUACCGUCCCACAUACAU
miR-329 1924 1930 1A hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-9 1787 1793 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA