Gene Page:PDE1A

Summary?
GeneID 5136
Symbol PDE1A
Synonyms CAM-PDE-1A|HCAM-1|HCAM1|HSPDE1A
Description phosphodiesterase 1A
Reference MIM:171890|HGNC:HGNC:8774|Ensembl:ENSG00000115252|HPRD:01387|Vega:OTTHUMG00000132596
Gene type protein-coding
Map location 2q32.1
Pascal p-value 0.025
Sherlock p-value 0.414
Fetal beta 0.102
eGene Caudate basal ganglia
Cerebellar Hemisphere
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMedfor genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs940335 chr7 99159332 PDE1A 5136 0.17 trans
rs10931021 2 183368517 PDE1A ENSG00000115252.14 7.612E-7 0 19402 gtex_brain_putamen_basal
rs2368301 2 183369652 PDE1A ENSG00000115252.14 6.274E-8 0 18267 gtex_brain_putamen_basal
rs9789764 2 183373914 PDE1A ENSG00000115252.14 3.683E-6 0 14005 gtex_brain_putamen_basal
rs6433976 2 183376081 PDE1A ENSG00000115252.14 4.07E-7 0 11838 gtex_brain_putamen_basal
rs7595111 2 183376369 PDE1A ENSG00000115252.14 4.07E-7 0 11550 gtex_brain_putamen_basal
rs10175845 2 183378125 PDE1A ENSG00000115252.14 3.501E-6 0 9794 gtex_brain_putamen_basal
rs2082135 2 183378257 PDE1A ENSG00000115252.14 4.047E-7 0 9662 gtex_brain_putamen_basal
rs4666850 2 183378710 PDE1A ENSG00000115252.14 4.044E-7 0 9209 gtex_brain_putamen_basal
rs1991596 2 183379073 PDE1A ENSG00000115252.14 3.21E-6 0 8846 gtex_brain_putamen_basal
rs2887207 2 183380721 PDE1A ENSG00000115252.14 5.189E-7 0 7198 gtex_brain_putamen_basal
rs934261 2 183382345 PDE1A ENSG00000115252.14 3.897E-7 0 5574 gtex_brain_putamen_basal
rs10174383 2 183382731 PDE1A ENSG00000115252.14 3.706E-6 0 5188 gtex_brain_putamen_basal
rs1430149 2 183383268 PDE1A ENSG00000115252.14 3.86E-7 0 4651 gtex_brain_putamen_basal
rs720245 2 183390144 PDE1A ENSG00000115252.14 3.732E-7 0 -2225 gtex_brain_putamen_basal
rs1835340 2 183393811 PDE1A ENSG00000115252.14 3.781E-7 0 -5892 gtex_brain_putamen_basal
rs4580353 2 183395232 PDE1A ENSG00000115252.14 1.46E-8 0 -7313 gtex_brain_putamen_basal
rs1430151 2 183395511 PDE1A ENSG00000115252.14 3.902E-9 0 -7592 gtex_brain_putamen_basal
rs68098724 2 183395631 PDE1A ENSG00000115252.14 3.902E-9 0 -7712 gtex_brain_putamen_basal
rs13027181 2 183395815 PDE1A ENSG00000115252.14 3.9E-9 0 -7896 gtex_brain_putamen_basal
rs13026884 2 183395835 PDE1A ENSG00000115252.14 3.9E-9 0 -7916 gtex_brain_putamen_basal
rs13026896 2 183395871 PDE1A ENSG00000115252.14 3.9E-9 0 -7952 gtex_brain_putamen_basal
rs397816195 2 183396838 PDE1A ENSG00000115252.14 6.306E-9 0 -8919年 gtex_brain_putamen_basal
rs12693309 2 183397510 PDE1A ENSG00000115252.14 3.808E-9 0 -9591 gtex_brain_putamen_basal
rs12693310 2 183397531 PDE1A ENSG00000115252.14 2.054E-8 0 -9612 gtex_brain_putamen_basal
rs12693311 2 183397542 PDE1A ENSG00000115252.14 1.152E-8 0 -9623 gtex_brain_putamen_basal
rs11686003 2 183397980 PDE1A ENSG00000115252.14 3.266E-9 0 -10061 gtex_brain_putamen_basal
rs1430152 2 183398404 PDE1A ENSG00000115252.14 3.898E-9 0 -10485 gtex_brain_putamen_basal
rs35418011 2 183398774 PDE1A ENSG00000115252.14 3.898E-9 0 -10855 gtex_brain_putamen_basal
rs12162422 2 183398896 PDE1A ENSG00000115252.14 3.898E-9 0 -10977 gtex_brain_putamen_basal
rs11449946 2 183399798 PDE1A ENSG00000115252.14 6.769E-7 0 -11879 gtex_brain_putamen_basal
rs35385135 2 183400076 PDE1A ENSG00000115252.14 1.35E-8 0 -12157 gtex_brain_putamen_basal
rs11689324 2 183400185 PDE1A ENSG00000115252.14 1.458E-8 0 -12266 gtex_brain_putamen_basal
rs12473783 2 183400661 PDE1A ENSG00000115252.14 3.898E-9 0 -12742 gtex_brain_putamen_basal
rs10182788 2 183400730 PDE1A ENSG00000115252.14 1.53E-13 0 -12811 gtex_brain_putamen_basal
rs1583113 2 183401353 PDE1A ENSG00000115252.14 3.898E-9 0 -13434 gtex_brain_putamen_basal
rs1430153 2 183401673 PDE1A ENSG00000115252.14 1.53E-13 0 -13754 gtex_brain_putamen_basal
rs1430154 2 183401789 PDE1A ENSG00000115252.14 1.53E-13 0 -13870 gtex_brain_putamen_basal
rs7570760 2 183402841 PDE1A ENSG00000115252.14 3.898E-9 0 -14922 gtex_brain_putamen_basal
rs1430155 2 183403506 PDE1A ENSG00000115252.14 3.546E-7 0 -15587 gtex_brain_putamen_basal
rs10931023 2 183403962 PDE1A ENSG00000115252.14 4.51E-10 0 -16043 gtex_brain_putamen_basal
rs1965089 2 183404968 PDE1A ENSG00000115252.14 7.045E-11 0 -17049 gtex_brain_putamen_basal
rs7598587 2 183407212 PDE1A ENSG00000115252.14 1.458E-8 0 -19293年 gtex_brain_putamen_basal
rs2368281 2 183408260 PDE1A ENSG00000115252.14 3.083E-7 0 -20341 gtex_brain_putamen_basal
rs934262 2 183409319 PDE1A ENSG00000115252.14 7.08E-8 0 -21400 gtex_brain_putamen_basal
rs934263 2 183409320 PDE1A ENSG00000115252.14 7.113E-8 0 -21401 gtex_brain_putamen_basal
rs6747954 2 183415490 PDE1A ENSG00000115252.14 4.514E-12 0 -27571 gtex_brain_putamen_basal
rs6711313 2 183416697 PDE1A ENSG00000115252.14 1.53E-13 0 -28778 gtex_brain_putamen_basal
rs4666588 2 183417707 PDE1A ENSG00000115252.14 4.417E-13 0 -29788 gtex_brain_putamen_basal
rs1430156 2 183423637 PDE1A ENSG00000115252.14 1.458E-8 0 -35718 gtex_brain_putamen_basal
rs4666589 2 183424775 PDE1A ENSG00000115252.14 2.514E-7 0 -36856 gtex_brain_putamen_basal
rs111326379 2 183425701 PDE1A ENSG00000115252.14 1.144E-11 0 -37782 gtex_brain_putamen_basal
rs139837068 2 183428054 PDE1A ENSG00000115252.14 1.282E-8 0 -40135 gtex_brain_putamen_basal
rs7558348 2 183428186 PDE1A ENSG00000115252.14 2.633E-6 0 -40267 gtex_brain_putamen_basal
rs10931024 2 183441026 PDE1A ENSG00000115252.14 1.503E-6 0 -53107 gtex_brain_putamen_basal
rs12479286 2 183441218 PDE1A ENSG00000115252.14 7.34E-7 0 -53299 gtex_brain_putamen_basal
rs7604873 2 183441726 PDE1A ENSG00000115252.14 6.309E-11 0 -53807 gtex_brain_putamen_basal
rs6758080 2 183442443 PDE1A ENSG00000115252.14 7.34E-7 0 -54524 gtex_brain_putamen_basal
rs7570144 2 183443136 PDE1A ENSG00000115252.14 7.34E-7 0 -55217 gtex_brain_putamen_basal
rs1527878 2 183446535 PDE1A ENSG00000115252.14 1.394E-9 0 -58616 gtex_brain_putamen_basal
rs1918700 2 183449725 PDE1A ENSG00000115252.14 8.161E-11 0 -61806 gtex_brain_putamen_basal
rs4490143 2 183450403 PDE1A ENSG00000115252.14 4.857E-10 0 -62484 gtex_brain_putamen_basal
rs2368330 2 183453542 PDE1A ENSG00000115252.14 2.561E-6 0 -65623 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
共有269个时间点秘密策划,n = 38胎儿samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
UGT8 0.96 0.94
PLP1 0.95 0.96
HSPA2 0.94 0.94
GLDN 0.94 0.91
TF 0.94 0.95
CNDP1 0.94 0.89
SLC31A2 0.94 0.78
ABCA8 0.93 0.89
KLK6 0.93 0.94
FOLH1 0.93 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NR2C2AP -0.53 -0.78
NKIRAS2 -0.53 -0.68
TRNAU1AP -0.52 -0.73
TBC1D10A -0.52 -0.58
TUBB2B -0.52 -0.80
ALKBH2 -0.52 -0.76
PLEKHO1 -0.52 -0.77
KIAA1949 -0.51 -0.74
CCDC28B -0.51 -0.83
AC009133.1 -0.51 -0.69

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG TASTE TRANSDUCTION 52 28 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING 32 25 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2 101 78 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 109 80 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS 30 23 All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 43 32 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR 100 74 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE 54 40 All SZGR 2.0 genes in this pathway
REACTOME CGMP EFFECTS 19 13 All SZGR 2.0 genes in this pathway
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 25 19 All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 78 49 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 32 15 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314 188 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191 123 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295 149 All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940 425 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
WU ALZHEIMER DISEASE DN 19 12 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION UP 20 10 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
NIELSEN GIST 98 66 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway