Gene Page:CRLF3
概括?
| GeneID | 51379 |
| Symbol | CRLF3 |
| Synonyms | CREME-9|CREME9|CRLM9|CYTOR4|FRWS|p48.2 |
| Description | cytokine receptor-like factor 3 |
| Reference | MIM:614853|HGNC:HGNC:17177|Ensembl:ENSG00000176390|HPRD:16757|Vega:OTTHUMG00000179005 |
| Gene type | protein-coding |
| Map location | 17q11.2 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.158 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Myers' cis & trans Meta |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7147147 | chr14 | 55407943 | CRLF3 | 51379 | 0.18 | trans | ||
| rs216425 | 17 | 28943479 | CRLF3 | ENSG00000176390.10 | 3.13E-6 | 0.01 | 208315 | gtex_brain_ba24 |
| rs536819 | 17 | 28948792 | CRLF3 | ENSG00000176390.10 | 3.134E-6 | 0.01 | 203002 | gtex_brain_ba24 |
| rs563674 | 17 | 28949444 | CRLF3 | ENSG00000176390.10 | 3.225E-6 | 0.01 | 202350 | gtex_brain_ba24 |
| rs383436 | 17 | 28959179 | CRLF3 | ENSG00000176390.10 | 2.891E-6 | 0.01 | 192615 | gtex_brain_ba24 |
| rs60343873 | 17 | 28959568 | CRLF3 | ENSG00000176390.10 | 2.881E-6 | 0.01 | 192226 | gtex_brain_ba24 |
| rs59363273 | 17 | 28959743 | CRLF3 | ENSG00000176390.10 | 2.741E-6 | 0.01 | 192051 | gtex_brain_ba24 |
| rs386180 | 17 | 28959917 | CRLF3 | ENSG00000176390.10 | 2.873E-6 | 0.01 | 191877 | gtex_brain_ba24 |
| rs407604 | 17 | 28962472 | CRLF3 | ENSG00000176390.10 | 2.82E-6 | 0.01 | 189322 | gtex_brain_ba24 |
| rs11650821 | 17 | 28968150 | CRLF3 | ENSG00000176390.10 | 2.85E-6 | 0.01 | 183644 | gtex_brain_ba24 |
| rs11655681 | 17 | 28969013 | CRLF3 | ENSG00000176390.10 | 2.786E-6 | 0.01 | 182781 | gtex_brain_ba24 |
| rs72019394 | 17 | 28969921 | CRLF3 | ENSG00000176390.10 | 2.451E-6 | 0.01 | 181873 | gtex_brain_ba24 |
| rs201414282 | 17 | 28970318 | CRLF3 | ENSG00000176390.10 | 2.096E-6 | 0.01 | 181476 | gtex_brain_ba24 |
| rs28653580 | 17 | 28990047 | CRLF3 | ENSG00000176390.10 | 3.417E-6 | 0.01 | 161747 | gtex_brain_ba24 |
| rs28609811 | 17 | 28990145 | CRLF3 | ENSG00000176390.10 | 3.308E-6 | 0.01 | 161649 | gtex_brain_ba24 |
| rs73267828 | 17 | 29003806 | CRLF3 | ENSG00000176390.10 | 3.072E-6 | 0.01 | 147988 | gtex_brain_ba24 |
| rs56378576 | 17 | 29010120 | CRLF3 | ENSG00000176390.10 | 2.944E-6 | 0.01 | 141674 | gtex_brain_ba24 |
| rs60890550 | 17 | 29030861 | CRLF3 | ENSG00000176390.10 | 1.881E-6 | 0.01 | 120933 | gtex_brain_ba24 |
| rs180950758 | 17 | 29036425 | CRLF3 | ENSG00000176390.10 | 2.874E-7 | 0.01 | 115369 | gtex_brain_ba24 |
| rs75259757 | 17 | 29036967 | CRLF3 | ENSG00000176390.10 | 2.448E-6 | 0.01 | 114827 | gtex_brain_ba24 |
| rs55661352 | 17 | 29045628 | CRLF3 | ENSG00000176390.10 | 1.928E-6 | 0.01 | 106166 | gtex_brain_ba24 |
| rs11654722 | 17 | 29046782 | CRLF3 | ENSG00000176390.10 | 1.928E-6 | 0.01 | 105012 | gtex_brain_ba24 |
| rs75259692 | 17 | 29056712 | CRLF3 | ENSG00000176390.10 | 2.38E-6 | 0.01 | 95082 | gtex_brain_ba24 |
| rs8075097 | 17 | 29057326 | CRLF3 | ENSG00000176390.10 | 2.358E-6 | 0.01 | 94468 | gtex_brain_ba24 |
| rs59447372 | 17 | 29057585 | CRLF3 | ENSG00000176390.10 | 2.472E-6 | 0.01 | 94209 | gtex_brain_ba24 |
| rs61643715 | 17 | 29057762 | CRLF3 | ENSG00000176390.10 | 2.476E-6 | 0.01 | 94032 | gtex_brain_ba24 |
| rs190899853 | 17 | 29058250 | CRLF3 | ENSG00000176390.10 | 8.824E-7 | 0.01 | 93544 | gtex_brain_ba24 |
| rs11650924 | 17 | 29058676 | CRLF3 | ENSG00000176390.10 | 2.137E-6 | 0.01 | 93118 | gtex_brain_ba24 |
| rs11650928 | 17 | 29058694 | CRLF3 | ENSG00000176390.10 | 1.741E-6 | 0.01 | 93100 | gtex_brain_ba24 |
| rs8080829 | 17 | 29058730 | CRLF3 | ENSG00000176390.10 | 2.611E-6 | 0.01 | 93064 | gtex_brain_ba24 |
| rs8079891 | 17 | 29058863 | CRLF3 | ENSG00000176390.10 | 2.623E-6 | 0.01 | 92931 | gtex_brain_ba24 |
| rs73267858 | 17 | 29059737 | CRLF3 | ENSG00000176390.10 | 2.733E-6 | 0.01 | 92057 | gtex_brain_ba24 |
| rs11656844 | 17 | 29060597 | CRLF3 | ENSG00000176390.10 | 2.849E-6 | 0.01 | 91197 | gtex_brain_ba24 |
| rs11652533 | 17 | 29060601 | CRLF3 | ENSG00000176390.10 | 2.849E-6 | 0.01 | 91193 | gtex_brain_ba24 |
| rs11652631 | 17 | 29060766 | CRLF3 | ENSG00000176390.10 | 2.819E-6 | 0.01 | 91028 | gtex_brain_ba24 |
| rs73267861 | 17 | 29061632 | CRLF3 | ENSG00000176390.10 | 2.938E-6 | 0.01 | 90162 | gtex_brain_ba24 |
| rs72310809 | 17 | 29062041 | CRLF3 | ENSG00000176390.10 | 2.51E-6 | 0.01 | 89753 | gtex_brain_ba24 |
| rs28445742 | 17 | 29062403 | CRLF3 | ENSG00000176390.10 | 2.973E-6 | 0.01 | 89391 | gtex_brain_ba24 |
| rs9892599 | 17 | 29062491 | CRLF3 | ENSG00000176390.10 | 3.08E-6 | 0.01 | 89303 | gtex_brain_ba24 |
| RS397857602 | 17 | 29062712 | CRLF3 | ENSG00000176390.10 | 2.246E-6 | 0.01 | 89082 | gtex_brain_ba24 |
| rs79139233 | 17 | 29063635 | CRLF3 | ENSG00000176390.10 | 3.262E-6 | 0.01 | 88159 | gtex_brain_ba24 |
| RS77498725 | 17 | 29063986 | CRLF3 | ENSG00000176390.10 | 3.299E-6 | 0.01 | 87808 | gtex_brain_ba24 |
| rs77171603 | 17 | 29064291 | CRLF3 | ENSG00000176390.10 | 3.094E-6 | 0.01 | 87503 | gtex_brain_ba24 |
| rs58412069 | 17 | 29064353 | CRLF3 | ENSG00000176390.10 | 3.325E-6 | 0.01 | 87441 | gtex_brain_ba24 |
| rs61223720 | 17 | 29064362 | CRLF3 | ENSG00000176390.10 | 3.325E-6 | 0.01 | 87432 | gtex_brain_ba24 |
| rs59749841 | 17 | 29064701 | CRLF3 | ENSG00000176390.10 | 3.275E-6 | 0.01 | 87093 | gtex_brain_ba24 |
| rs57698184 | 17 | 29064918 | CRLF3 | ENSG00000176390.10 | 2.306E-6 | 0.01 | 86876 | gtex_brain_ba24 |
| rs59923796 | 17 | 29064919 | CRLF3 | ENSG00000176390.10 | 1.836E-6 | 0.01 | 86875 | gtex_brain_ba24 |
| rs57424113 | 17 | 29065031 | CRLF3 | ENSG00000176390.10 | 3.019E-6 | 0.01 | 86763 | gtex_brain_ba24 |
| rs59573398 | 17 | 29065044 | CRLF3 | ENSG00000176390.10 | 3.062E-6 | 0.01 | 86750 | gtex_brain_ba24 |
| rs9889887 | 17 | 29065541 | CRLF3 | ENSG00000176390.10 | 3.364E-6 | 0.01 | 86253 | gtex_brain_ba24 |
| rs57347666 | 17 | 29069543 | CRLF3 | ENSG00000176390.10 | 3.473E-6 | 0.01 | 82251 | gtex_brain_ba24 |
| rs117560728 | 17 | 29070938 | CRLF3 | ENSG00000176390.10 | 2.795E-6 | 0.01 | 80856 | gtex_brain_ba24 |
| rs3907291 | 17 | 29071337 | CRLF3 | ENSG00000176390.10 | 3.069E-6 | 0.01 | 80457 | gtex_brain_ba24 |
| rs74812983 | 17 | 29071457 | CRLF3 | ENSG00000176390.10 | 3.196E-6 | 0.01 | 80337 | gtex_brain_ba24 |
| rs2322203 | 17 | 29072265 | CRLF3 | ENSG00000176390.10 | 2.577E-6 | 0.01 | 79529 | gtex_brain_ba24 |
| rs9898318 | 17 | 29072756 | CRLF3 | ENSG00000176390.10 | 3.391E-6 | 0.01 | 79038 | gtex_brain_ba24 |
| rs9892562 | 17 | 29072886 | CRLF3 | ENSG00000176390.10 | 3.195E-6 | 0.01 | 78908 | gtex_brain_ba24 |
| rs8070372 | 17 | 29075816 | CRLF3 | ENSG00000176390.10 | 2.425e-6 | 0.01 | 75978 | gtex_brain_ba24 |
| rs8069400 | 17 | 29075967 | CRLF3 | ENSG00000176390.10 | 3.402E-6 | 0.01 | 75827 | gtex_brain_ba24 |
| rs8073164 | 17 | 29076018 | CRLF3 | ENSG00000176390.10 | 3.148E-6 | 0.01 | 75776 | gtex_brain_ba24 |
| rs2626985 | 17 | 29077437 | CRLF3 | ENSG00000176390.10 | 3.281E-6 | 0.01 | 74357 | gtex_brain_ba24 |
| rs7209182 | 17 | 29078813 | CRLF3 | ENSG00000176390.10 | 3.021E-6 | 0.01 | 72981 | gtex_brain_ba24 |
| rs28615788 | 17 | 29079579 | CRLF3 | ENSG00000176390.10 | 3.426E-6 | 0.01 | 72215 | gtex_brain_ba24 |
| rs9891769 | 17 | 29080783 | CRLF3 | ENSG00000176390.10 | 3.393E-6 | 0.01 | 71011 | gtex_brain_ba24 |
| rs9912649 | 17 | 29080784 | CRLF3 | ENSG00000176390.10 | 3.431E-6 | 0.01 | 71010 | gtex_brain_ba24 |
| rs35689940 | 17 | 29081526 | CRLF3 | ENSG00000176390.10 | 3.125E-6 | 0.01 | 70268 | gtex_brain_ba24 |
| rs28710057 | 17 | 29083070 | CRLF3 | ENSG00000176390.10 | 3.268E-6 | 0.01 | 68724 | gtex_brain_ba24 |
| rs74963370 | 17 | 29083714 | CRLF3 | ENSG00000176390.10 | 3.306E-6 | 0.01 | 68080 | gtex_brain_ba24 |
| rs28433704 | 17 | 29084285 | CRLF3 | ENSG00000176390.10 | 3.453E-6 | 0.01 | 67509 | gtex_brain_ba24 |
| rs55870272 | 17 | 29086105 | CRLF3 | ENSG00000176390.10 | 2.874E-6 | 0.01 | 65689 | gtex_brain_ba24 |
| rs9911268 | 17 | 29094253 | CRLF3 | ENSG00000176390.10 | 2.929E-6 | 0.01 | 57541 | gtex_brain_ba24 |
| rs61146082 | 17 | 29100087 | CRLF3 | ENSG00000176390.10 | 1.593E-6 | 0.01 | 51707 | gtex_brain_ba24 |
| rs1055670 | 17 | 29100394 | CRLF3 | ENSG00000176390.10 | 3.167E-6 | 0.01 | 51400 | gtex_brain_ba24 |
| rs7225953 | 17 | 29103631 | CRLF3 | ENSG00000176390.10 | 2.12E-6 | 0.01 | 48163 | gtex_brain_ba24 |
| rs9916725 | 17 | 29107471 | CRLF3 | ENSG00000176390.10 | 3.223E-6 | 0.01 | 44323 | gtex_brain_ba24 |
| rs9916727 | 17 | 29107472 | CRLF3 | ENSG00000176390.10 | 3.223E-6 | 0.01 | 44322 | gtex_brain_ba24 |
| rs60546131 | 17 | 29109908 | CRLF3 | ENSG00000176390.10 | 2.614E-6 | 0.01 | 41886 | gtex_brain_ba24 |
| rs58824755 | 17 | 29109919 | CRLF3 | ENSG00000176390.10 | 2.289E-6 | 0.01 | 41875 | gtex_brain_ba24 |
| rs202019708 | 17 | 29109927 | CRLF3 | ENSG00000176390.10 | 1.98E-6 | 0.01 | 41867 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 16HR UP | 225 | 139 | 该途径中的所有SZGR 2.0基因 |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | 该途径中的所有SZGR 2.0基因 |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | 该途径中的所有SZGR 2.0基因 |
| MOOTHA PGC | 420 | 269 | 该途径中的所有SZGR 2.0基因 |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | 该途径中的所有SZGR 2.0基因 |
| FONTAINE FOLLICULAR THYROID ADENOMA UP | 75 | 43 | 该途径中的所有SZGR 2.0基因 |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN | 321 | 200 | 该途径中的所有SZGR 2.0基因 |
| NABA SECRETED FACTORS | 344 | 197 | 该途径中的所有SZGR 2.0基因 |
| NABA MATRISOME ASSOCIATED | 753 | 411 | 该途径中的所有SZGR 2.0基因 |
| NABA MATRISOME | 1028 | 559 | 该途径中的所有SZGR 2.0基因 |