Gene Page:AMOTL2

概括?
基因 51421
Symbol AMOTL2
Synonyms LCCP
Description angiomotin like 2
Reference MIM:614658|HGNC:HGNC:17812|Ensembl:ENSG00000114019|HPRD:16485|Vega:OTTHUMG00000159777
Gene type protein-coding
Map location 3q21-q22
Pascal p-value 0.298
Fetal beta 0.214
DMG 1 (# studies)

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06503171 3 134083286 AMOTL2 1.258E-4 -0.364 0.03 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception我们eks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0042802 identical protein binding IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
去：0005923 tight junction IEA Brain (GO term level: 10) -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME SIGNALING BY HIPPO 22 15 该途径中的所有SZGR 2.0基因
UDAYAKUMAR MED1 TARGETS DN 240 171 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 6HR DN 167 100 该途径中的所有SZGR 2.0基因
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 该途径中的所有SZGR 2.0基因
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 该途径中的所有SZGR 2.0基因
BERENJENO ROCK SIGNALING NOT VIA RHOA DN 48 34 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 该途径中的所有SZGR 2.0基因
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION 50 31 该途径中的所有SZGR 2.0基因
GROSS HYPOXIA VIA ELK3 UP 209 139 该途径中的所有SZGR 2.0基因
GROSS HYPOXIA VIA ELK3 ONLY UP 33 18 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 该途径中的所有SZGR 2.0基因
AMIT EGF RESPONSE 120 HELA 69 47 该途径中的所有SZGR 2.0基因
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
LI WILMS TUMOR VS FETAL KIDNEY 1 UP 182 119 该途径中的所有SZGR 2.0基因
YAMAZAKI TCEB3 TARGETS UP 175 116 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
LU AGING BRAIN UP 262 186 该途径中的所有SZGR 2.0基因
SARTIPY NORMAL AT INSULIN RESISTANCE UP 34 27 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 6HR DN 160 101 该途径中的所有SZGR 2.0基因
BURTON ADIPOGENESIS 9 92 59 该途径中的所有SZGR 2.0基因
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G 95 62 该途径中的所有SZGR 2.0基因
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 171 96 该途径中的所有SZGR 2.0基因
LABBE WNT3A TARGETS UP 112 71 该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤课程DN 210 141 该途径中的所有SZGR 2.0基因
WONG EMBRYONIC STEM CELL CORE 335 193 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 该途径中的所有SZGR 2.0基因
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 该途径中的所有SZGR 2.0基因
PASINI SUZ12 TARGETS DN 315 215 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS DN 882 538 该途径中的所有SZGR 2.0基因
WINZEN DEGRADED VIA KHSRP 100 70 该途径中的所有SZGR 2.0基因
Smad2或Smad3的Koinuma目标 824 528 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
PHONG TNF RESPONSE NOT VIA P38 337 236 该途径中的所有SZGR 2.0基因
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-129-5p 1582 1589 1A,m8 hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-145 1033 1039 m8 hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-149 942 949 1A,m8 hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-150 1083 1090 1A,m8 hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-182 1678 1684年 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-200bc/429 1798 1804 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-224 1276 1282 m8 HSA-MIR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-24 955 961 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-27 1664 1670 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-30-5p 1546 1553年 1A,m8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-324-3p 1273 1279 1A HSA-MIR-324-3P CCACUGCCCCAGGUGCUGCUGG
miR-381 638 644 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-382 1608 1615 1A,m8 hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
miR-9 1680 1686年 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
mir-96 1678 1684年 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC