Gene Page:PRKAG2

Summary?
GeneID 51422
Symbol PRKAG2
Synonyms AAKG|AAKG2|CMH6|H91620p|WPWS
Description protein kinase AMP-activated non-catalytic subunit gamma 2
Reference MIM:602743|HGNC:HGNC:9386|Ensembl:ENSG00000106617|HPRD:04119|Vega:OTTHUMG00000157324
Gene type protein-coding
Map location 7q36.1
Pascal p-value 0.018
Sherlock p-value 0.211
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14873699 7 151469323 PRKAG2 6.99E-5 0.428 0.024 DMG:Wockner_2014
cg03574882 7 151574332 PRKAG2 5.966E-4 -0.226 0.05 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 67 57 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 42 35 All SZGR 2.0 genes in this pathway
BIOCARTA LEPTIN PATHWAY 11 11 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 19 16 All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 87 64 All SZGR 2.0 genes in this pathway
REACTOME强度GRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 15 13 All SZGR 2.0 genes in this pathway
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 18 15 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK 10 9 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168 115 All SZGR 2.0 genes in this pathway
REACTOME PKB MEDIATED EVENTS 29 23 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 108 72 All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 71 51 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 149 84 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 39 27 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP 116 68 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 100 75 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261 153 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 240 MCF10A 57 36 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 108 68 All SZGR 2.0 genes in this pathway
TSUDA ALVEOLAR SOFT PART SARCOMA 10 7 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 79 50 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标 344 215 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162 103 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway