Gene Page:PDGFA

Summary？
基因 5154
象征 PDGFA
Synonyms pDGF-A|PDGF1
Description 血小板衍生的生长因子亚基A
Reference MIM：173430|HGNC：HGNC：8799|ENSEMBL：ENSG00000197461|HPRD:01424|Vega：Otthumg00000151412
基因类型 蛋白质编码
Map location 7p22
Sherlock p-value 0.054
胎儿β -1.192
DMG 1(# studies)
主持人 皮质
Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
DMG：JAFFE_2016 全基因组DNA甲基化分析 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 1
表达 Meta-analysis of gene expression pvalue: 1.463

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
CG22476295 7 559000 PDGFA 1.83E-9 -0.01 1.57E-6 DMG：JAFFE_2016

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
rs1578978 CHR8 118196802 PDGFA 5154 0.02 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005161 platelet-derived growth factor receptor binding IDA 2836953
去：0005161 platelet-derived growth factor receptor binding IDA 2439522
去：0005161 platelet-derived growth factor receptor binding IPI 2536956
GO:0008083 生长因子活性 IEA -
GO:0048407 血小板衍生的生长因子结合 IPI 7073684
GO：0042803 蛋白质同构化活性 IDA 2836953|3754619
GO:0043498 细胞表面结合 IDA 291037|2538439|2836953
GO：0046982 蛋白质异二聚化活性 IPI 7073684
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0001775 细胞激活 TAS 10508235
去：0007267 细胞细胞信号传导 TAS 2842868
GO：0010544 negative regulation of platelet activation IDA 2538439
GO：0010512 磷脂酰肌醇生物合成过程的负调节 IDA 2538439
GO:0008283 cell proliferation IEA -
去：0009790 胚胎发展 TAS 10508235
GO：0048008 platelet-derived growth factor receptor signaling pathway IDA 2439522|2536956|2836953
GO:0042060 wound healing TAS 10508235
GO:0014910 调节平滑肌细胞迁移 IDA 9409235
GO:0050919 负趋化性 IDA 9409235
GO：0032956 regulation of actin cytoskeleton organization TAS 10508235
去：0030335 positive regulation of cell migration IDA 17470632
GO:0045740 DNA复制的阳性调节 IDA 2439522|2836953|10806482
GO：0048146 positive regulation of fibroblast proliferation IDA 2439522|10806482
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 经验 287022
去：0005576 细胞外区域 IEA -
去：0005615 细胞外空间 IDA 3754619
去：0016020 membrane IEA -
去：0009986 cell surface IDA 291037|2836953
GO:0031089 血小板致密的颗粒管 经验 287022

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg mapk信号通路 267 205 All SZGR 2.0 genes in this pathway
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
kegg焦点粘附 201 138 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节 216 144 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
Kegg神经胶质瘤 65 56 All SZGR 2.0 genes in this pathway
KEGG前列腺癌 89 75 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
Biocarta fordam途径 29 24 All SZGR 2.0 genes in this pathway
BIOCARTA PPARA通路 58 43 All SZGR 2.0 genes in this pathway
Biocarta PDGF途径 32 25 All SZGR 2.0 genes in this pathway
Biocarta EDG1途径 27 24 All SZGR 2.0 genes in this pathway
PID神经酰胺途径 48 37 All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 89 56 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 95 76 All SZGR 2.0 genes in this pathway
反应组止血 466 331 All SZGR 2.0 genes in this pathway
Reactome血小板激活信号传导和聚集 208 138 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP 137 94 All SZGR 2.0 genes in this pathway
VMYB vs CMYB DN的LIU目标 43 30. All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 6hr DN的Takeda目标 41 29 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标 204 140 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合红细胞的TONKS目标 157 104 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214 155 All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺48小时DN 64 39 All SZGR 2.0 genes in this pathway
kokkinakis甲硫氨酸剥夺96小时DN 75 50 All SZGR 2.0 genes in this pathway
Chiaradonna肿瘤转化KRAS CDC25 UP 58 39 All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
Wang Barretts食道和食道癌 26 12 All SZGR 2.0 genes in this pathway
Borlak肝癌EGF UP 57 41 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN 51 42 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM2 153 102 All SZGR 2.0 genes in this pathway
留置权乳腺癌变质 35 25 All SZGR 2.0 genes in this pathway
Khetchoumian Trim24靶向 47 38 All SZGR 2.0 genes in this pathway
GALIE TUMOR ANGIOGENESIS 8 7 All SZGR 2.0 genes in this pathway
狮子转移 539 324 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向 292 168 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP 69 55 All SZGR 2.0 genes in this pathway
HE PTEN TARGETS UP 16 15 All SZGR 2.0 genes in this pathway
Benporath循环基因 648 385 All SZGR 2.0 genes in this pathway
Stark前额叶皮层22Q11删除DN 517 309 All SZGR 2.0 genes in this pathway
Tenedini Megakaryocyte标记 66 48 All SZGR 2.0 genes in this pathway
Radaeva对IFNA1 DN的响应 10 5 All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214 133 All SZGR 2.0 genes in this pathway
卫生部对干扰素beta的反应 71 49 All SZGR 2.0 genes in this pathway
杰克逊DNMT1靶向 77 57 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
Bild HRAS致癌特征 261 166 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
monnier tradiatiation肿瘤逃脱DN 373 196 All SZGR 2.0 genes in this pathway
Hillion HMGA1B目标 92 68 All SZGR 2.0 genes in this pathway
Wang LSD1目标 24 14 All SZGR 2.0 genes in this pathway
Jepsen SMRT目标 33 23 All SZGR 2.0 genes in this pathway
Stearman肺癌早期与晚期 125 89 All SZGR 2.0 genes in this pathway
Martinez RB1靶向DN 543 317 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
Mishra癌相关的成纤维细胞 24 14 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
Labbe TGFB1靶向 102 64 All SZGR 2.0 genes in this pathway
lu肿瘤血管生成 25 22 All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记 165 118 All SZGR 2.0 genes in this pathway
pIONTEK PKD1 TARGETS DN 18 12 All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟B 53 36 All SZGR 2.0 genes in this pathway
MIZUKAMI HYPOXIA UP 12 12 All SZGR 2.0 genes in this pathway
张TLX目标36hr 221 150 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
张TLX目标 108 78 All SZGR 2.0 genes in this pathway
pOOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
Boyault肝癌子类G1 UP 113 70 All SZGR 2.0 genes in this pathway
Coulouarn暂时TGFB1签名 109 68 All SZGR 2.0 genes in this pathway
woo肝癌复发 105 75 All SZGR 2.0 genes in this pathway
开罗肝母细胞瘤 207 143 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
惠特菲尔德细胞周期M G1 148 95 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
Wang对GSK3抑制剂SB216763 DN的响应 374 217 All SZGR 2.0 genes in this pathway
Hoelzel NF1靶向 139 93 All SZGR 2.0 genes in this pathway
康AR目标 17 10 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标1 DN 63 39 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标2 DN 336 211 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化 100 70 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时 199 143 All SZGR 2.0 genes in this pathway
林乳腺干细胞向上 489 314 All SZGR 2.0 genes in this pathway
Zwang仅通过第二EGF脉冲瞬时向上 1725 838 All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上 1839 928 All SZGR 2.0 genes in this pathway
NABA分泌因素 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 48 54 M8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
mir-221/222 188 194 1a hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc