Gene Page:SCLY

Summary?
GeneID 51540
Symbol SCLY
Synonyms SCL|hSCL
Description selenocysteine lyase
Reference MIM:611056|HGNC:HGNC:18161|Ensembl:ENSG00000132330|HPRD:15303|Vega:OTTHUMG00000133336
Gene type protein-coding
Map location 2q37.3
Pascal p-value 0.347
Sherlock p-value 0.917
Fetal beta 0.148
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10173407 chr2 238868195 SCLY 51540 1.439E-4 cis
rs1446929 chr2 238870582 SCLY 51540 5.678E-4 cis
rs708078 chr2 238949742 SCLY 51540 3.758E-4 cis
rs821498 chr2 238952405 SCLY 51540 0 cis
rs1374386 chr2 238997955 SCLY 51540 8.558E-12 cis
rs11898344 chr2 239021689 SCLY 51540 0.01 cis
rs3948117 chr2 239024179 SCLY 51540 0 cis
rs10173407 chr2 238868195 SCLY 51540 0.01 trans
rs1446929 chr2 238870582 SCLY 51540 0.04 trans
rs708078 chr2 238949742 SCLY 51540 0.03 trans
rs821498 chr2 238952405 SCLY 51540 0.11 trans
rs1374386 chr2 238997955 SCLY 51540 2.189E-9 trans
rs41099 chr5 115832055 SCLY 51540 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SELENOAMINO ACID METABOLISM 26 18 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186 107 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176 104 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 125 68 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 93 40 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157 105 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211 119 All SZGR 2.0 genes in this pathway