Gene Page:PDHB
Summary?
| GeneID | 5162 |
| Symbol | PDHB |
| Synonyms | PDHBD|PDHE1-B|PHE1B |
| Description | pyruvate dehydrogenase (lipoamide) beta |
| Reference | MIM:179060|HGNC:HGNC:8808|Ensembl:ENSG00000168291|HPRD:01530|Vega:OTTHUMG00000159157 |
| Gene type | protein-coding |
| Map location | 3p21.1-p14.2 |
| Pascal p-value | 0.012 |
| Sherlock p-value | 0.062 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex 元 |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_clathrin G2Cdb.human_mitochondria G2Cdb.human_Synaptosome G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9857570 | 3 | 58280690 | PDHB | ENSG00000168291.8 | 1.751E-6 | 0 | 138894 | gtex_brain_ba24 |
| rs6445967 | 3 | 58282576 | PDHB | ENSG00000168291.8 | 1.751E-6 | 0 | 137008 | gtex_brain_ba24 |
| rs9846885 | 3 | 58285789 | PDHB | ENSG00000168291.8 | 1.751E-6 | 0 | 133795 | gtex_brain_ba24 |
| rs9847151 | 3 | 58285808 | PDHB | ENSG00000168291.8 | 1.751E-6 | 0 | 133776 | gtex_brain_ba24 |
| rs13325699 | 3 | 58286870 | PDHB | ENSG00000168291.8 | 1.751E-6 | 0 | 132714 | gtex_brain_ba24 |
| rs7640866 | 3 | 58288362 | PDHB | ENSG00000168291.8 | 1.751E-6 | 0 | 131222 | gtex_brain_ba24 |
| rs62259323 | 3 | 58291047 | PDHB | ENSG00000168291.8 | 1.549E-6 | 0 | 128537 | gtex_brain_ba24 |
| rs62259324 | 3 | 58291107 | PDHB | ENSG00000168291.8 | 1.545E-6 | 0 | 128477 | gtex_brain_ba24 |
| rs9867776 | 3 | 58295401 | PDHB | ENSG00000168291.8 | 1.34E-6 | 0 | 124183 | gtex_brain_ba24 |
| rs4336086 | 3 | 58297390 | PDHB | ENSG00000168291.8 | 1.288E-6 | 0 | 122194 | gtex_brain_ba24 |
| rs201546547 | 3 | 58297410 | PDHB | ENSG00000168291.8 | 1.729E-6 | 0 | 122174 | gtex_brain_ba24 |
| rs35955376 | 3 | 58297779 | PDHB | ENSG00000168291.8 | 1.284E-6 | 0 | 121805 | gtex_brain_ba24 |
| rs2292673 | 3 | 58301901 | PDHB | ENSG00000168291.8 | 1.216E-6 | 0 | 117683 | gtex_brain_ba24 |
| rs2292674 | 3 | 58302404 | PDHB | ENSG00000168291.8 | 2.303E-6 | 0 | 117180 | gtex_brain_ba24 |
| rs14927 | 3 | 58305033 | PDHB | ENSG00000168291.8 | 8.036E-7 | 0 | 114551 | gtex_brain_ba24 |
| rs12688 | 3 | 58305079 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 114505 | gtex_brain_ba24 |
| rs12630913 | 3 | 58306070 | PDHB | ENSG00000168291.8 | 1.097E-6 | 0 | 113514 | gtex_brain_ba24 |
| rs12636243 | 3 | 58306216 | PDHB | ENSG00000168291.8 | 1.208E-6 | 0 | 113368 | gtex_brain_ba24 |
| rs12633655 | 3 | 58306321 | PDHB | ENSG00000168291.8 | 1.872E-6 | 0 | 113263 | gtex_brain_ba24 |
| rs11712758 | 3 | 58306579 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 113005 | gtex_brain_ba24 |
| rs11713627 | 3 | 58306946 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 112638 | gtex_brain_ba24 |
| rs6777105 | 3 | 58307644 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 111940 | gtex_brain_ba24 |
| rs1913715 | 3 | 58308214 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 111370 | gtex_brain_ba24 |
| rs1913716 | 3 | 58308331 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 111253 | gtex_brain_ba24 |
| rs6791748 | 3 | 58308519 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 111065 | gtex_brain_ba24 |
| rs1055973 | 3 | 58308960 | PDHB | ENSG00000168291.8 | 8.036E-7 | 0 | 110624 | gtex_brain_ba24 |
| rs34611088 | 3 | 58312923 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 106661 | gtex_brain_ba24 |
| rs13059916 | 3 | 58316364 | PDHB | ENSG00000168291.8 | 1.085E-6 | 0 | 103220 | gtex_brain_ba24 |
| rs11714574 | 3 | 58380465 | PDHB | ENSG00000168291.8 | 2.396E-7 | 0 | 39119 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF134 | 0.95 | 0.96 |
| ZKSCAN5 | 0.94 | 0.95 |
| VEZT | 0.94 | 0.95 |
| TSR1 | 0.94 | 0.94 |
| HMG20A | 0.94 | 0.95 |
| THRAP3 | 0.94 | 0.94 |
| ZMYM4 | 0.93 | 0.95 |
| OSBPL11 | 0.93 | 0.94 |
| CAPN7 | 0.93 | 0.94 |
| DIS3 | 0.93 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.82 | -0.90 |
| MT-CO2 | -0.82 | -0.90 |
| AF347015.27 | -0.80 | -0.88 |
| FXYD1 | -0.79 | -0.88 |
| AF347015.33 | -0.79 | -0.86 |
| AF347015.8 | -0.78 | -0.89 |
| MT-CYB | -0.78 | -0.87 |
| IFI27 | -0.77 | -0.87 |
| AF347015.15 | -0.76 | -0.86 |
| HIGD1B | -0.75 | -0.86 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOLYSIS GLUCONEOGENESIS | 62 | 41 | All SZGR 2.0 genes in this pathway |
| KEGG CITRATE CYCLE TCA CYCLE | 32 | 23 | All SZGR 2.0 genes in this pathway |
| KEGG VALINE LEUCINE AND ISOLEUCINE BIOSYNTHESIS | 11 | 8 | All SZGR 2.0 genes in this pathway |
| KEGG PYRUVATE METABOLISM | 40 | 26 | All SZGR 2.0 genes in this pathway |
| KEGG BUTANOATE新陈代谢 | 34 | 20 | All SZGR 2.0 genes in this pathway |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 48 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 141 | 85 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 13 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME PYRUVATE METABOLISM | 19 | 14 | All SZGR 2.0 genes in this pathway |
| WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP | 108 | 67 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA DN | 526 | 357 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| BARRIER COLON CANCER RECURRENCE UP | 42 | 28 | All SZGR 2.0 genes in this pathway |
| DITTMER PTHLH TARGETS DN | 73 | 51 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| BURTON ADIPOGENESIS 6 | 189 | 112 | All SZGR 2.0 genes in this pathway |
| WONG MITOCHONDRIA GENE MODULE | 217 | 122 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| 金所有DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| 金所有DISORDERS CALB1 CORR UP | 548 | 370 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 | 227 | 149 | All SZGR 2.0 genes in this pathway |