SZGR2 - Beplay体育中心

Summary？

基因	5166
象征	PDK4
Synonyms	-
Description	丙酮酸脱氢酶激酶4
Reference	MIM：602527\|HGNC:HGNC:8812\|Ensembl：ENSG00000004799\|HPRD:03957\|Vega:OTTHUMG00000153977
基因类型	蛋白质编码
Map location	7q21.3
pascal p-value	0.219
Sherlock p-value	0.277
DEG P值	DEG：ZHAO_2015：P = 5.29E-05：Q = 0.0489
胎儿β	-2.228
DMG	1(# studies)
主持人	Cerebellar Hemisphere Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Zhao_2015	RNA Sequencing analysis	转录组测序和全基因组的关联分析揭示了精神分裂症和躁郁症中的溶酶体功能和肌动蛋白细胞骨架重塑。
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
表达	Meta-analysis of gene expression	pvalue: 2.071

Section I. Genetics and epigenetics annotation

Differentially methylated gene

probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG22171829	7	95225520	PDK4	1.843E-4	-0.625	0.034	DMG：Wockner_2014

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	QVALUE	EQTL类型
RS1022180	CHR6	165969395	PDK4	5166	0.11	反式
rs7032605	Chr9	30426130	PDK4	5166	0.09	反式
rs10969802	Chr9	30636427	PDK4	5166	0.03	反式
rs10969816	Chr9	30661611	PDK4	5166	0.03	反式
rs12350524	Chr9	30743421	PDK4	5166	0.03	反式
RS12343068	Chr9	30783524	PDK4	5166	0.03	反式
RS10511868	Chr9	30816504	PDK4	5166	0.03	反式
rs303549	Chr9	106039392	PDK4	5166	0.12	反式
RS7334509	CHR13	46692410	PDK4	5166	0.11	反式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	pearson's Correlation	斯皮尔曼的相关性
DNMT1	0.97	0.97
GCN1L1	0.96	0.96
NUP62	0.96	0.97
LIG3	0.96	0.96
ZXDC	0.95	0.95
BRPF1	0.95	0.96
SF1	0.95	0.97
GEMIN4	0.95	0.96
QRICH1	0.95	0.97
pRPF8	0.95	0.96

Top 10 negatively co-expressed genes
Gene	pearson's Correlation	斯皮尔曼的相关性
AF347015.31	-0.78	-0.92
MT-CO2	-0.76	-0.92
AF347015.27	-0.75	-0.90
AF347015.33	-0.75	-0.88
C5orf53	-0.74	-0.79
FXYD1	-0.73	-0.87
mt-cyb	-0.73	-0.88
S100B	-0.73	-0.85
AF347015.8	-0.73	-0.90
HIGD1B	-0.72	-0.88

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0000155	two-component sensor activity	IEA		-
去：0005524	ATP binding	IEA		-
GO:0004740	丙酮酸脱氢酶（乙酰基转移）激酶活性	TAS		8798399
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006006	葡萄糖代谢过程	TAS		8798399
去：0005975	碳水化合物代谢过程	IEA		-
GO:0007165	信号转导	IEA		-
GO：0016310	磷酸化	IEA		-
GO：0018106	肽基 - 抗苷酸磷酸化	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005739	mitochondrion	TAS		8798399
去：0005743	线粒体内膜	IEA		-
去：0005759	线粒体基质	IEA		-

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
反应组丙酮酸代谢和柠檬酸TCA循环	48	32	All SZGR 2.0 genes in this pathway
Reactome TCA循环和呼吸电子传输	141	85	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	13	9	All SZGR 2.0 genes in this pathway
反应组丙酮酸代谢	19	14	All SZGR 2.0 genes in this pathway
pARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
Sengupta鼻咽癌与LMP1 DN	175	82	All SZGR 2.0 genes in this pathway
turashvili乳房小叶癌与导管正常DN	91	53	All SZGR 2.0 genes in this pathway
turashvili乳房小叶癌与小叶正常	94	59	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN	367	220	All SZGR 2.0 genes in this pathway
NUP98 HOXA9融合8D DN的Takeda目标	205	127	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN	142	90	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
Chiaradonna肿瘤转化KRAS CDC25 DN	51	35	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变	394	258	All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP	116	68	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN	62	44	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
Dauer Stat3靶向DN	50	34	All SZGR 2.0 genes in this pathway
Bertucci侵入性癌导管与小叶DN	46	34	All SZGR 2.0 genes in this pathway
里克曼头颈癌F	54	32	All SZGR 2.0 genes in this pathway
林被肿瘤微环境沉默	108	73	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7Q21 Q22 AMPLICON	76	33	All SZGR 2.0 genes in this pathway
BYSTRYKH造血细胞和脑QTL Trans	185	114	All SZGR 2.0 genes in this pathway
李肝癌电抗	60	42	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP	103	69	All SZGR 2.0 genes in this pathway
Kaab心脏中心与心室DN	261	183	All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE DN	18	14	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
Mulligan NTF3通过INSR和IGF1R DN信号传导	13	6	All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向	601	369	All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛	299	167	All SZGR 2.0 genes in this pathway
Fujii YBX1靶向	43	28	All SZGR 2.0 genes in this pathway
riggi ewing肉瘤祖先DN	191	123	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
等级结肠和直肠癌DN	101	65	All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜	425	298	All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN	70	43	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
Mootha PGC	420	269	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
Aguirre胰腺癌复制号	298	174	All SZGR 2.0 genes in this pathway
清肝癌子类CTNNB1 UP	176	110	All SZGR 2.0 genes in this pathway
清肝癌亚类增殖DN	179	97	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S3	266	180	All SZGR 2.0 genes in this pathway
Uzonyi对白三烯和凝血酶的反应	37	26	All SZGR 2.0 genes in this pathway
Nakayama软组织肿瘤PCA2 DN	80	51	All SZGR 2.0 genes in this pathway
YAO对孕酮簇1的时间反应1	68	50	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS DN	115	73	All SZGR 2.0 genes in this pathway
Ohguchi肝HNF4A靶向	44	30	All SZGR 2.0 genes in this pathway
BHAT ESR1不是通过AKT1 DN的目标	88	61	All SZGR 2.0 genes in this pathway
BHAT ESR1通过AKT1 DN目标	82	51	All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3	430	288	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
Servitja肝HNF1A靶向	135	96	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移6	29	20	All SZGR 2.0 genes in this pathway
wakabayashi脂肪形成PPARG绑定8D	658	397	All SZGR 2.0 genes in this pathway
杨Bcl3靶向	364	236	All SZGR 2.0 genes in this pathway
pLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
Plasari TGFB1通过NFIC 10小时信号传导	54	38	All SZGR 2.0 genes in this pathway
Wang MLL目标	289	188	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向DN	418	245	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway
Zwang击倒第二个EGF脉冲	293	119	All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上	1839	928	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-148/152	760	767	1A，M8	hsa-miR-148a	ucagugcacuacaacuuugu
				HSA-MIR-152^brain	UCAGUGCAUGACACUUGGG
				hsa-miR-148b	ucagugcaucacacaacuuugu
miR-15/16/195/424/497	49	55	M8	HSA-MIR-15A^brain	uagcagcacauaugguugug
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				HSA-MIR-15B^brain	UAGCAGCACAUCAUGGUUUACA
				HSA-MIR-195^SZ	uagcagaaaaauauuggc
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				HSA-MIR-497	cagcagcacacuguguuugu
miR-181	59	65	M8	HSA-MIR-181A^brain	AACAUUCAACGCUGUCGGUGAGU
				HSA-MIR-181B^SZ	AACAUUCAUUGCUGUCGGUGGG
				HSA-MIR-181C^brain	AACAUUCAACCUGUCGGUGAGU
				HSA-MIR-181D^brain	aacauucauuguugucggggguggguu
mir-9	1839	1846	1A，M8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:PDK4