Gene Page:ENPP1
Summary?
| GeneID | 5167 |
| Symbol | ENPP1 |
| Synonyms | ARHR2|COLED|M6S1|NPP1|NPPS|PC-1|PCA1|PDNP1 |
| Description | ectonucleotide pyrophosphatase/phosphodiesterase 1 |
| Reference | MIM:173335|HGNC:HGNC:3356|Ensembl:ENSG00000197594|HPRD:01415|Vega:OTTHUMG00000015572 |
| Gene type | protein-coding |
| Map location | 6q22-q23 |
| Pascal p-value | 0.203 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 1 |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg05417985 | 6 | 132128945 | ENPP1 | -0.029 | 0.31 | DMG:Nishioka_2013 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | 皮尔森的相关性 | Spearman's Correlation |
| FGFR4 | 0.73 | 0.51 |
| HPX | 0.70 | 0.49 |
| KIAA1683 | 0.69 | 0.52 |
| PLA2G4B | 0.69 | 0.50 |
| IL3RA | 0.67 | 0.50 |
| JMJD7-PLA2G4B | 0.67 | 0.50 |
| CSAD | 0.67 | 0.43 |
| AC008403.1 | 0.67 | 0.45 |
| CCDC84 | 0.67 | 0.51 |
| CCNL2 | 0.67 | 0.44 |
| 十大negatively co-expressed genes | ||
| Gene | 皮尔森的相关性 | Spearman's Correlation |
| PLA2G4A | -0.40 | -0.46 |
| RGS5 | -0.40 | -0.46 |
| CYCS | -0.39 | -0.42 |
| ABCG2 | -0.39 | -0.43 |
| NAPB | -0.38 | -0.39 |
| C6orf106 | -0.38 | -0.42 |
| TPMT | -0.38 | -0.44 |
| OSTF1 | -0.37 | -0.41 |
| CCDC25 | -0.37 | -0.41 |
| GHITM | -0.37 | -0.42 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | - | |
| GO:0003676 | nucleic acid binding | IEA | - | |
| GO:0005158 | insulin receptor binding | IDA | 7830796 | |
| GO:0005515 | protein binding | 新闻学会 | 11289049 | |
| GO:0005524 | ATP binding | IDA | 7830796 | |
| GO:0004551 | nucleotide diphosphatase activity | EXP | 8001561 | |
| GO:0004551 | nucleotide diphosphatase activity | IEA | - | |
| GO:0004519 | endonuclease activity | IEA | - | |
| GO:0004528 | phosphodiesterase I activity | IEA | - | |
| GO:0016787 | hydrolase activity | IEA | - | |
| GO:0042803 | protein homodimerization activity | IDA | 7830796 | |
| GO:0046872 | metal ion binding | IEA | - | |
| GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding | IC | 7830796 | |
| GO:0047429 | nucleoside-triphosphate diphosphatase activity | IDA | 7830796|10513816|11159191 |
|
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0001503 | ossification | IEA | - | |
| GO:0006091 | generation of precursor metabolites and energy | IDA | 12746903 | |
| GO:0008152 | metabolic process | IEA | - | |
| GO:0006796 | phosphate metabolic process | IDA | 10513816|11159191 | |
| GO:0009143 | nucleoside triphosphate catabolic process | IDA | 10513816 | |
| GO:0030500 | regulation of bone mineralization | IC | 10513816 | |
| GO:0030505 | inorganic diphosphate transport | IDA | 10513816 | |
| GO:0032869 | cellular response to insulin stimulus | IDA | 7830796|17849011 | |
| GO:0030279 | negative regulation of ossification | IEA | - | |
| GO:0030308 | negative regulation of cell growth | IDA | 17849011 | |
| GO:0030730 | sequestering of triacylglycerol | IDA | 17849011 | |
| GO:0030643 | cellular phosphate ion homeostasis | IDA | 11159191 | |
| GO:0031953 | negative regulation of protein amino acid autophosphorylation | IDA | 11289049 | |
| GO:0045599 | negative regulation of fat cell differentiation | IDA | 17849011 | |
| GO:0045719 | negative regulation of glycogen biosynthetic process | IDA | 11289049 | |
| GO:0046849 | bone remodeling | IEA | - | |
| GO:0046325 | negative regulation of glucose import | IDA | 17849011 | |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | IDA | 7830796|17849011 | |
| GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | IDA | 7830796 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005615 | extracellular space | IDA | 11159191 | |
| GO:0016021 | integral to membrane | TAS | 1315502 | |
| GO:0009986 | cell surface | IDA | 10513816 | |
| GO:0005886 | plasma membrane | EXP | 8001561 | |
| GO:0005886 | plasma membrane | IDA | 10513816 | |
| GO:0016323 | basolateral plasma membrane | NAS | 9553761 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PURINE METABOLISM | 159 | 96 | All SZGR 2.0 genes in this pathway |
| KEGG STARCH AND SUCROSE METABOLISM | 52 | 33 | All SZGR 2.0 genes in this pathway |
| KEGG RIBOFLAVIN METABOLISM | 16 | 11 | All SZGR 2.0 genes in this pathway |
| KEGG NICOTINATE AND NICOTINAMIDE METABOLISM | 24 | 16 | All SZGR 2.0 genes in this pathway |
| KEGG PANTOTHENATE AND COA BIOSYNTHESIS | 16 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF VITAMINS AND COFACTORS | 51 | 36 | All SZGR 2.0 genes in this pathway |
| NAKAMURA CANCER MICROENVIRONMENT UP | 26 | 14 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| JAEGER METASTASIS UP | 44 | 23 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP | 119 | 66 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
| CHEBOTAEV GR TARGETS UP | 77 | 62 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS B UP | 26 | 16 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS E UP | 97 | 60 | All SZGR 2.0 genes in this pathway |
| INGRAM SHH TARGETS UP | 127 | 79 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| PASQUALUCCI LYMPHOMA BY GC STAGE UP | 283 | 177 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 UP | 256 | 159 | All SZGR 2.0 genes in this pathway |
| ROZANOV MMP14 TARGETS UP | 266 | 171 | All SZGR 2.0 genes in this pathway |
| MANALO HYPOXIA DN | 289 | 166 | All SZGR 2.0 genes in this pathway |
| MANALO HYPOXIA UP | 207 | 145 | All SZGR 2.0 genes in this pathway |
| YAGI AML SURVIVAL | 129 | 87 | All SZGR 2.0 genes in this pathway |
| TRAYNOR RETT SYNDROM DN | 19 | 14 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| TSENG IRS1 TARGETS DN | 135 | 88 | All SZGR 2.0 genes in this pathway |
| HEDENFALK BREAST CANCER BRCA1 VS BRCA2 | 163 | 113 | All SZGR 2.0 genes in this pathway |
| TSENG ADIPOGENIC POTENTIAL DN | 46 | 28 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE DN | 373 | 196 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P7 | 90 | 52 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| RIGGI EWING SARCOMA PROGENITOR UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| HUANG FOXA2 TARGETS UP | 45 | 28 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B UP | 172 | 109 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| JIANG TIP30 TARGETS UP | 46 | 28 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | All SZGR 2.0 genes in this pathway |
| HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE UP | 36 | 24 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER LATE RECURRENCE DN | 69 | 48 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S2 | 115 | 74 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 DN | 88 | 61 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| PLASARI TGFB1 TARGETS 10HR UP | 199 | 143 | All SZGR 2.0 genes in this pathway |
| WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |