Gene Page:GHRL

Summary?
GeneID 51738
Symbol GHRL
Synonyms MTLRP
Description ghrelin/obestatin prepropeptide
Reference MIM:605353|HGNC:HGNC:18129|Ensembl:ENSG00000157017|HPRD:05638|Vega:OTTHUMG00000155360
Gene type protein-coding
Map location 3p25.3
Pascal p-value 0.482
Fetal beta -0.173
eGene Cerebellar Hemisphere
Cerebellum
Cortex
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance和Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 6

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10994209 chr10 61877705 GHRL 51738 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0016608 growth hormone-releasing hormone activity IEA -
GO:0016608 growth hormone-releasing hormone activity ISS 10604470
GO:0031768 ghrelin receptor binding ISS -
GO:0030296 protein tyrosine kinase activator activity IMP 15350694
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0051965 positive regulation of synaptogenesis IDA Synap (GO term level: 10) 16491079
GO:0051965 positive regulation of synaptogenesis IEA Synap (GO term level: 10) -
GO:0060079 regulation of excitatory postsynaptic membrane potential IEA neuron, Synap (GO term level: 10) -
GO:0016358 dendrite development IDA neurite, dendrite (GO term level: 11) 16491079
GO:0016358 dendrite development IEA neurite, dendrite (GO term level: 11) -
GO:0000187 activation of MAPK activity IMP 15350694
GO:0001937 negative regulation of endothelial cell proliferation IDA 15572208
GO:0030252 growth hormone secretion TAS 16511605
GO:0007204 elevation of cytosolic calcium ion concentration ISS -
GO:0007186 G-protein coupled receptor protein signaling pathway ISS 10604470
GO:0006006 glucose metabolic process NAS 17392603
GO:0008343 adult feeding behavior ISS -
GO:0009755 hormone-mediated signaling TAS 16511605
GO:0008154 actin polymerization or depolymerization IDA 15232612
GO:0043066 negative regulation of apoptosis IDA 15158140
GO:0032024 positive regulation of insulin secretion ISS -
GO:0032100 positive regulation of appetite IEA -
GO:0032100 positive regulation of appetite ISS -
去:0016525 negative regulation of angiogenesis NAS 15572208
GO:0040013 negative regulation of locomotion IEA -
GO:0042127 regulation of cell proliferation IDA 15564328|16394173
GO:0051216 cartilage development NAS 15576457
GO:0040018 positive regulation of multicellular organism growth IC 16511605
GO:0032691 negative regulation of interleukin-1 beta production IDA 15232612
GO:0043400 cortisol secretion NAS 17201814
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process IDA 15232612
GO:0050728 negative regulation of inflammatory response IDA 15232612
GO:0043627 response to estrogen stimulus IDA 15292338
GO:0046676 negative regulation of insulin secretion IEA -
GO:0046697 decidualization IDA 17494105
去:0045409 negative regulation of interleukin-6 biosynthetic process IDA 15232612
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0030424 axon IDA neuron, axon, Neurotransmitter (GO term level: 6) 17113048
GO:0005576 extracellular region IDA 17392603
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IDA 15039149|15531532
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 16 11 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 35 24 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
ROLEF GLIS3 TARGETS 37 29 All SZGR 2.0 genes in this pathway