Gene Page:PGM3

Summary?
GeneID 5238
Symbol PGM3
Synonyms AGM1|IMD23|PAGM|PGM 3
Description phosphoglucomutase 3
Reference MIM:172100|HGNC:HGNC:8907|Ensembl:ENSG00000013375|HPRD:01390|Vega:OTTHUMG00000015110
Gene type protein-coding
Map location 6q14.1-q15
Pascal p-value 8.268E-4
Sherlock p-value 0.603
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4546623 chr8 98411165 PGM3 5238 0.01 trans
rs7328038 chr13 65364069 PGM3 5238 0.05 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DTNA 0.78 0.81
ZFYVE21 0.77 0.81
TSPAN7 0.76 0.79
RETSAT 0.75 0.78
NT5E 0.73 0.76
GPM6B 0.72 0.78
CDH20 0.72 0.73
PGM1 0.72 0.74
C14orf159 0.72 0.73
MAP3K5 0.71 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBMX2 -0.52 -0.52
RPS25P8 -0.46 -0.52
UPF3B -0.46 -0.41
RPL28 -0.46 -0.51
ZNF695 -0.46 -0.34
EXOSC8 -0.46 -0.44
RPL11 -0.45 -0.53
RPS16P1 -0.45 -0.54
EZH2 -0.45 -0.41
RP9 -0.45 -0.45

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
走:0000287 magnesium ion binding IEA -
走:0004610 phosphoacetylglucosamine mutase activity IDA 11004509
走:0016853 isomerase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
走:0006041 glucosamine metabolic process NAS 11004509
走:0005975 carbohydrate metabolic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
走:0005575 cellular_component ND -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM 44 30 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188 116 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS 14 8 All SZGR 2.0 genes in this pathway
REACTOME ASPARAGINE N LINKED GLYCOSYLATION 81 54 All SZGR 2.0 genes in this pathway
REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN 29 17 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN 186 114 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 UP 89 51 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER 83 52 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
由喀斯特IWANAGA致癌PTEN 181 112 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway