SZGR2 - Beplay体育中心

Summary？

基因	5270
象征	serpine2
Synonyms	gdn \| gdnpf \| pi-7 \| pi7 \| pn-1 \| pn1 \| pni
Description	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Reference	MIM：177010\|HGNC:HGNC:8951\|Ensembl：ENSG00000135919\|HPRD：01510\|Vega：Otthumg00000133163
基因类型	蛋白质编码
Map location	2q36.1
Pascal p-value	0.464
Sherlock p-value	0.103
胎儿β	-1.664
DMG	1(# studies)
主持人	Myers' cis & trans
Support	G2CDB.HUMANPSP

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1
GSMA_IIA	Genome scan meta-analysis (All samples)	PSR：0.00916
gsma_iie	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01016
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

差异甲基化基因

Probe	染色体	位置	最近的基因	p（dis）	Beta (dis)	fdr（dis）	学习
cg23055236	2	224873911	serpine2	4.317E-4	0.513	0.045	DMG：Wockner_2014

EQTL注释

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS13395823	CHR2	225743518	serpine2	5270		0.04		顺式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO:0004867	丝氨酸型内肽酶抑制剂活性	nas		2877744\|3997857
去：0008201	肝素约束	nas		3997857
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0007399	nervous system development	IEA	神经突（GO期限：5）	-
GO:0007275	multicellular organismal development	IEA		-
GO:0030154	细胞分化	IEA		-
GO:0030162	调节蛋白水解	nas		2877744\|3997857
去：0030334	细胞迁移的调节	nas		2877744
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005576	细胞外区域	nas		2877744\|3997857

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
Schuetz乳腺癌导管侵入性	351	230	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE DN	21	13	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病	1382	904	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
Horiuchi WTAP靶向	306	188	All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 10D的Takeda目标	194	122	All SZGR 2.0 genes in this pathway
Hoebeke淋巴干细胞DN	86	59	All SZGR 2.0 genes in this pathway
Mullighan MLL签名1 DN	242	165	All SZGR 2.0 genes in this pathway
Mullighan MLL签名2 DN	281	186	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP	87	45	All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN	485	334	All SZGR 2.0 genes in this pathway
Castellano NRAS靶向	68	41	All SZGR 2.0 genes in this pathway
阿霉素的Graessmann凋亡	1142	669	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向D	38	23	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变	394	258	All SZGR 2.0 genes in this pathway
Johansson神经胶质作用是PDGFB	58	44	All SZGR 2.0 genes in this pathway
Mahadevan伊马替尼抵抗	23	15	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮	176	111	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP	227	137	All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM4	261	153	All SZGR 2.0 genes in this pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER LARGE VS TINY UP	44	24	All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向	1037	673	All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标	795	478	All SZGR 2.0 genes in this pathway
狮子有Sox4结合位点	40	26	All SZGR 2.0 genes in this pathway
狮子转移	539	324	All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP	35	32	All SZGR 2.0 genes in this pathway
gotzmann上皮到间充质过渡dn	206	136	All SZGR 2.0 genes in this pathway
Amit EGF响应480 HELA	164	118	All SZGR 2.0 genes in this pathway
Cervera SDHB目标2	114	76	All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向	84	51	All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植被拒绝与OK	63	48	All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者	555	346	All SZGR 2.0 genes in this pathway
LEI MYB目标	318	215	All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤MS	48	32	All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML	246	180	All SZGR 2.0 genes in this pathway
Yagi AML Fab标记	191	131	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
ONGUSAHA TP53 TARGETS	38	23	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP	56	35	All SZGR 2.0 genes in this pathway
Simbulan Parp1靶向	31	23	All SZGR 2.0 genes in this pathway
麦克拉克兰牙齿龋齿DN	245	144	All SZGR 2.0 genes in this pathway
RODWELL老化肾脏没有血液	222	139	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
伯顿成生7	51	34	All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN	287	208	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP	253	147	All SZGR 2.0 genes in this pathway
Kyng DNA损坏4NQO或伽马辐射	15	13	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默	461	298	All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变	180	114	All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION DN	60	38	All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN	564	326	All SZGR 2.0 genes in this pathway
LE SKI TARGETS UP	17	12	All SZGR 2.0 genes in this pathway
威尔逊蛋白酶在肿瘤骨接口上	21	14	All SZGR 2.0 genes in this pathway
Boquest干细胞向上	260	174	All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜	425	298	All SZGR 2.0 genes in this pathway
huper乳房基础与腔内	54	29	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
Ruiz TNC靶向DN	142	79	All SZGR 2.0 genes in this pathway
Schraets MLL靶向	35	21	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
LEE SP4 THYMOCYTE	14	11	All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
Cheok对胃嘌呤和高清MTX DN的反应	25	18	All SZGR 2.0 genes in this pathway
清肝癌子类CTNNB1 DN	170	105	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
开罗肝母细胞瘤	207	143	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP	166	105	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应14	143	86	All SZGR 2.0 genes in this pathway
中村脂肪形成早期DN	38	27	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE DN	38	25	All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP	307	182	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
Hirsch细胞转换签名	242	159	All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应	549	316	All SZGR 2.0 genes in this pathway
STAT3的Azare肿瘤转化	121	70	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化	100	70	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
Servitja Islet HNF1A靶向	163	111	All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A	770	480	All SZGR 2.0 genes in this pathway
Guillaumond KLF10靶向	51	39	All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向DN	418	245	All SZGR 2.0 genes in this pathway
通过p38完成的phong TNF响应	227	151	All SZGR 2.0 genes in this pathway
Rattenbacher由Celf1绑定	467	251	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A	182	108	All SZGR 2.0 genes in this pathway
boudoukha由IGF2BP2绑定	111	59	All SZGR 2.0 genes in this pathway
NABA ECM监管机构	238	125	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
mir-410	548	554	1a	hsa-miR-410	aauauaacacagauggcugu
miR-542-3p	628	634	M8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:serpine2