Gene Page:ACP2
Summary?
| GeneID | 53 |
| Symbol | ACP2 |
| Synonyms | LAP |
| Description | 酸性磷酸酶2,lysosomal |
| Reference | MIM:171650|HGNC:HGNC:123|Ensembl:ENSG00000134575|HPRD:01375|Vega:OTTHUMG00000166949 |
| Gene type | protein-coding |
| Map location | 11p11.2|11p12-p11 |
| Pascal p-value | 0.03 |
| Sherlock p-value | 4.513E-4 |
| eGene | 小脑 |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RPUSD3 | 0.69 | 0.72 |
| CGREF1 | 0.68 | 0.72 |
| HMOX2 | 0.68 | 0.72 |
| SLC25A19 | 0.68 | 0.69 |
| MECR | 0.68 | 0.72 |
| MKKS | 0.67 | 0.70 |
| FXYD7 | 0.67 | 0.69 |
| DHRS7B | 0.66 | 0.70 |
| C6orf154 | 0.66 | 0.71 |
| MAP1LC3A | 0.66 | 0.72 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.18 | -0.42 | -0.28 |
| MT-ATP8 | -0.35 | -0.18 |
| ANP32C | -0.35 | -0.34 |
| AF347015.26 | -0.34 | -0.20 |
| AC100783.1 | -0.33 | -0.27 |
| HSP90AB4P | -0.33 | -0.33 |
| AC010300.1 | -0.33 | -0.33 |
| NSBP1 | -0.33 | -0.31 |
| AF347015.8 | -0.32 | -0.18 |
| EIF5B | -0.32 | -0.35 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG RIBOFLAVIN METABOLISM | 16 | 11 | All SZGR 2.0 genes in this pathway |
| KEGG LYSOSOME | 121 | 83 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP | 139 | 83 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN | 153 | 100 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| WU HBX TARGETS 2 DN | 16 | 11 | All SZGR 2.0 genes in this pathway |
| JOSEPH RESPONSE TO SODIUM BUTYRATE DN | 64 | 45 | All SZGR 2.0 genes in this pathway |
| WANG CISPLATIN RESPONSE AND XPC DN | 228 | 146 | All SZGR 2.0 genes in this pathway |
| WU HBX TARGETS 1 UP | 16 | 10 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER LATE RECURRENCE DN | 69 | 48 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 8 21 TRANSLOCATION | 368 | 247 | All SZGR 2.0 genes in this pathway |
| SASSON RESPONSE TO GONADOTROPHINS UP | 91 | 59 | All SZGR 2.0 genes in this pathway |
| SASSON RESPONSE TO FORSKOLIN UP | 90 | 58 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| TIAN BHLHA15 TARGETS | 16 | 8 | All SZGR 2.0 genes in this pathway |