Gene Page:PIN1

Summary?
GeneID 5300
Symbol PIN1
Synonyms DOD|UBL5
Description peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Reference MIM:601052|HGNC:HGNC:8988|Ensembl:ENSG00000127445|HPRD:03031|Vega:OTTHUMG00000180388
Gene type protein-coding
Map location 19p13
Pascal p-value 0.228
Sherlock p-value 0.23
Fetal beta -1.568
DMG 2 (# studies)
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0573

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04699474 19 9945708 PIN1 2.24E-5 -0.307 0.017 DMG:Wockner_2014
cg22728790 19 9945653 PIN1 1.08E-7 -0.007 2.34E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PTPN3 0.87 0.59
PTPN4 0.86 0.81
AKAP2 0.85 0.74
MCF2 0.85 0.62
FAM19A4 0.84 0.33
RORA 0.84 0.47
EPN3 0.84 0.45
RASSF3 0.84 0.49
CHRNA3 0.83 0.53
SLC17A6 0.83 0.69
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C16orf74 -0.32 -0.53
RGS20 -0.32 -0.48
C1orf61 -0.31 -0.61
CXCL14 -0.31 -0.48
OAF -0.31 -0.47
CSAG1 -0.30 -0.50
CLDN10 -0.29 -0.47
AF347015.21 -0.29 -0.54
EIF4EBP3 -0.29 -0.53
VAMP5 -0.29 -0.54

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA -
GO:0005515 protein binding 新闻学会 11470801
GO:0016853 isomerase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006457 protein folding IEA -
GO:0007049 cell cycle IEA -
GO:0007088 regulation of mitosis TAS 10391244
GO:0042127 regulation of cell proliferation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 8606777

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BCL2 Bcl-2 B-cell CLL/lymphoma 2 - HPRD 11988841
BCL2 Bcl-2 B-cell CLL/lymphoma 2 Affinity Capture-Western BioGRID 11326318
CCNB1 CCNB cyclin B1 - HPRD 9499405
CCND1 BCL1 | D11S287E | PRAD1 | U21B31 cyclin D1 PIN1 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human PIN1 and Cyclin D1 from an unspecified species. BIND 11805292
CDC2 CDC28A | CDK1 | DKFZp686L20222 | MGC111195 cell division cycle 2, G1 to S and G2 to M - HPRD 11774038
CDC25C CDC25 cell division cycle 25 homolog C (S. pombe) - HPRD 9482729|9499405
|10037602|9499405|10037602
CDC25C CDC25 cell division cycle 25 homolog C (S. pombe) - HPRD,BioGRID 9499405|10037602
CDC27 APC3 | CDC27Hs | D0S1430E | D17S978E | HNUC cell division cycle 27 homolog (S. cerevisiae) - HPRD,BioGRID 9499405|10939594
CDC27 APC3 | CDC27Hs | D0S1430E | D17S978E | HNUC cell division cycle 27 homolog (S. cerevisiae) Pin1 interacts with Cdc27. BIND 9499405
CDK9 C-2k | CDC2L4 | CTK1 | PITALRE | TAK cyclin-dependent kinase 9 - HPRD 11575923
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide - HPRD,BioGRID 11940573
CSNK2A2 CK2A2 | CSNK2A1 | FLJ43934 casein kinase 2, alpha prime polypeptide - HPRD,BioGRID 11940573
CSNK2B CK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224 casein kinase 2, beta polypeptide - HPRD 11940573
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa - HPRD,BioGRID 11533658
DAB2 DOC-2 | DOC2 | FLJ26626 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) - HPRD,BioGRID 12881709
DDX24 - DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 Two-hybrid BioGRID 16169070
GGA2 FLJ20966 | KIAA1080 | VEAR golgi associated, gamma adaptin ear containing, ARF binding protein 2 Two-hybrid BioGRID 16189514
GPAA1 GAA1 | hGAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) Two-hybrid BioGRID 16169070
HNRNPC C1 | C2 | HNRNP | HNRPC | MGC104306 | MGC105117 | MGC117353 | MGC131677 | SNRPC 异构核核糖核蛋白C (C1、C2) Two-hybrid BioGRID 16189514
JUN AP-1 | AP1 | c-Jun jun oncogene - HPRD,BioGRID 11432833
KIF20B DKFZp434B0435 | DKFZp434P0810 | KRMP1 | MPHOSPH1 | MPP-1 | MPP1 kinesin family member 20B - HPRD,BioGRID 11470801
KLHL20 KHLHX | KLEIP | KLHLX | RP3-383J4.3 kelch-like 20 (Drosophila) Two-hybrid BioGRID 16169070
LEPR CD295 | OBR leptin receptor Two-hybrid BioGRID 16169070
MAPT DDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAU microtubule-associated protein tau - HPRD,BioGRID 10391244
MDFI I-MF | I-mfa MyoD family inhibitor Two-hybrid BioGRID 16189514
MYT1 C20orf36 | MTF1 | MYTI | PLPB1 myelin transcription factor 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 10504341
NFATC2 KIAA0611 | NFAT1 | NFATP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 - HPRD,BioGRID 11356192
NONO NMT55 | NRB54 | P54 | P54NRB non-POU domain containing, octamer-binding Two-hybrid BioGRID 16189514
PKMYT1 DKFZp547K1610 | FLJ20093 | MYT1 protein kinase, membrane associated tyrosine/threonine 1 - HPRD,BioGRID 9499405|10504341
PKMYT1 DKFZp547K1610 | FLJ20093 | MYT1 protein kinase, membrane associated tyrosine/threonine 1 Pin1 interacts with phosphorylated Myt1. BIND 10504341
PLK1 PLK | STPK13 polo-like kinase 1 (Drosophila) - HPRD,BioGRID 9499405
PLK1 PLK | STPK13 polo-like kinase 1 (Drosophila) Pin1 interacts with PLK1. BIND 9499405
POLR2A MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa - HPRD 10932246
POLR2A MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa Affinity Capture-Western BioGRID 10393805
PTOV1 ACID2 | DKFZp586I111 | MGC71475 prostate tumor overexpressed 1 Two-hybrid BioGRID 16169070
PTPN1 PTP1B protein tyrosine phosphatase, non-receptor type 1 - HPRD 9499405
RAB4A HRES-1/RAB4 | RAB4 RAB4A, member RAS oncogene family - HPRD,BioGRID 10888662
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 Raf-1 interacts with Pin1. This interaction was modelled on a demonstrated interaction between human Raf-1 and Pin1 from monkey and unspecified species. BIND 15664191
RAI1 DKFZp434A139 | KIAA1820 | MGC12824 | SMCR | SMS retinoic acid induced 1 Two-hybrid BioGRID 16189514
RBBP8 CTIP | RIM retinoblastoma binding protein 8 Two-hybrid BioGRID 16189514
RBPMS HERMES RNA binding protein with multiple splicing Two-hybrid BioGRID 16189514
SFRS12 DKFZp564B176 | MGC133045 | SRrp508 | SRrp86 splicing factor, arginine/serine-rich 12 - HPRD 14559993
SOCS3 ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3 抑制细胞因子信号3 Two-hybrid BioGRID 16169070
SUPT5H FLJ34157 | SPT5 | SPT5H suppressor of Ty 5 homolog (S. cerevisiae) - HPRD,BioGRID 11575923
TOP2A TOP2 | TP2A topoisomerase (DNA) II alpha 170kDa - HPRD,BioGRID 11940573
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 - HPRD,BioGRID 12388558|12397362
TP73 P73 tumor protein p73 Pin1 interacts with phosphorylated p73-alpha BIND 15175157
TP73 P73 tumor protein p73 Pin1 interacts with p73-beta. BIND 15175157
TRAF2 MGC:45012 | TRAP | TRAP3 TNF receptor-associated factor 2 Two-hybrid BioGRID 16189514
TSC22D4 THG-1 | THG1 TSC22 domain family, member 4 Two-hybrid BioGRID 16189514
VHL HRCA1 | RCA1 | VHL1 von Hippel-Lindau tumor suppressor Affinity Capture-MS BioGRID 17353931
WEE1 DKFZp686I18166 | FLJ16446 | WEE1A | WEE1hu WEE1 homolog (S. pombe) Affinity Capture-Western
Far Western		 BioGRID 9499405
ZCCHC10 FLJ20094 zinc finger, CCHC domain containing 10 Two-hybrid BioGRID 16169070
ZMIZ2 DKFZp761I2123 | KIAA1886 | ZIMP7 | hZIMP7 zinc finger, MIZ-type containing 2 Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 71 51 All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY 34 28 All SZGR 2.0 genes in this pathway
ST WNT BETA CATENIN PATHWAY 34 28 All SZGR 2.0 genes in this pathway
PID P73PATHWAY 79 59 All SZGR 2.0 genes in this pathway
PID MYC PATHWAY 25 22 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 59 50 All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 66 45 All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159 116 All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING 31 19 All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 73 57 All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279 178 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER 22 19 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 121 79 All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS DN 16 12 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 52 33 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOGONIA 24 17 All SZGR 2.0 genes in this pathway
金ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
金BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
金ALL DISORDERS DURATION CORR DN 146 90 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194 133 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-200bc/429 111 117 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU