Gene Page:PITX3

Summary?
GeneID 5309
Symbol PITX3
Synonyms ASMD|ASOD|CTPP4|CTRCT11|PTX3
Description paired like homeodomain 3
Reference MIM:602669|HGNC:HGNC:9006|Ensembl:ENSG00000107859|HPRD:04051|Vega:OTTHUMG00000018952
Gene type protein-coding
Map location 10q24.32
Pascal p-value 0.028
Fetal beta -0.255

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CYBB 0.78 0.76
LCP1 0.75 0.70
DOCK2 0.75 0.71
ITGB2 0.74 0.70
NCKAP1L 0.74 0.68
TLR7 0.74 0.66
SYK 0.73 0.67
CSF1R 0.72 0.70
IRF8 0.72 0.67
LAPTM5 0.72 0.68
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.18 -0.29 -0.28
AF347015.2 -0.28 -0.27
MT-CO2 -0.27 -0.28
AF347015.21 -0.27 -0.22
AF347015.31 -0.26 -0.27
AF347015.26 -0.25 -0.24
AF347015.8 -0.25 -0.25
AC100783.1 -0.25 -0.27
IL32 -0.24 -0.20
CXCL14 -0.24 -0.19

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity IEA -
GO:0043565 sequence-specific DNA binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0048666 neuron development IEA neuron (GO term level: 9) -
GO:0030901 midbrain development IEA Brain (GO term level: 8) -
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0009887 organ morphogenesis TAS 9620774
GO:0007275 multicellular organismal development IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BENPORATH SUZ12 TARGETS 1038 678 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652 441 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS UP 13 10 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 88 59 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-133 220 226 m8 hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-328 236 242 1A hsa-miR-328brain CUGGCCCUCUCUGCCCUUCCGU
miR-339 217 223 1A hsa-miR-339 UCCCUGUCCUCCAGGAGCUCA
miR-542-5p 20 27 1A,m8 hsa-miR-542-5p UCGGGGAUCAUCAUGUCACGAG