Gene Page:PLAT

Summary?
GeneID 5327
Symbol PLAT
Synonyms T-PA|TPA
Description plasminogen activator, tissue type
Reference MIM:173370|HGNC:HGNC:9051|Ensembl:ENSG00000104368|HPRD:01419|Vega:OTTHUMG00000164072
Gene type protein-coding
Map location 8p12
Pascal p-value 0.121
Sherlock p-value 0.636
Fetal beta -0.711
DMG 1 (# studies)
Support Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression Meta-analysis of gene expression Pvalue: 1.352
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06931905 8 42036940 PLAT 4.38E-5 0.274 0.021 DMG:Wockner_2014
cg04563438 8 42065244 PLAT 4.044E-4 -0.363 0.044 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
IFI44L 0.93 0.86
PARP9 0.91 0.87
IFIT3 0.90 0.81
IFIT1 0.89 0.72
TAP1 0.87 0.74
IRF9 0.86 0.72
IFI35 0.85 0.73
IFITM3 0.84 0.67
PSMB8 0.83 0.73
SP110 0.83 0.79
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NEURL4 -0.50 -0.64
TCOF1 -0.50 -0.57
SPTAN1 -0.50 -0.61
NOVA2 -0.49 -0.64
MYO18A -0.49 -0.52
PELP1 -0.49 -0.60
CLIP2 -0.49 -0.58
RRP1 -0.49 -0.56
KIAA0427 -0.48 -0.59
DHX37 -0.48 -0.60

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0004252 serine-type endopeptidase activity IEA glutamate (GO term level: 7) -
GO:0008233 peptidase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006464 蛋白质改性过程 TAS 3087818
GO:0006508 proteolysis TAS 3087818
GO:0007596 blood coagulation TAS 3839198
GO:0048008 platelet-derived growth factor receptor signaling pathway IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005856 cytoskeleton IDA 18029348
GO:0005576 extracellular region EXP 2503541|2962641
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IEA -
GO:0005737 cytoplasm IEA -
GO:0030141 secretory granule IEA -
GO:0045177 apical part of cell IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ANXA2 ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36| PAP-IV annexin A2 - HPRD,BioGRID 11978811|12468550
CALR CRT | FLJ26680 | RO | SSA | cC1qR calreticulin - HPRD,BioGRID 9359841
CKAP4 CLIMP-63 | ERGIC-63 | MGC99554 | p63 cytoskeleton-associated protein 4 - HPRD 12913003
CLEC3B DKFZp686H17246 | TN | TNA C-type lectin domain family 3, member B - HPRD,BioGRID 12694198
F10 FX | FXA coagulation factor X - HPRD,BioGRID 11371191
F2 PT coagulation factor II (thrombin) Co-crystal Structure BioGRID 10543954
FGA Fib2 | MGC119422 | MGC119423 | MGC119425 fibrinogen alpha chain - HPRD,BioGRID 3088041|11170397
GRIN1 NMDA1 | NMDAR1 | NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 - HPRD 15448144
HMGB1 DKFZp686A04236 | HMG1 | HMG3 | SBP-1 high-mobility group box 1 - HPRD,BioGRID 1909331|8366113
KRT8 CARD2 | CK8 | CYK8 | K2C8 | K8 | KO keratin 8 - HPRD,BioGRID 9988531
LAMA1 LAMA laminin, alpha 1 - HPRD,BioGRID 8360181
LAMA3 BM600 | E170 | LAMNA | LOCS | lama3a laminin, alpha 3 - HPRD 10956663
LAMA5 KIAA1907 laminin, alpha 5 Reconstituted Complex BioGRID 10956663
LRP1 A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) - HPRD,BioGRID 1502153|10632583
LRP1B LRP-DIT | LRPDIT low density lipoprotein-related protein 1B (deleted in tumors) - HPRD 11384978
MAPK1 ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk mitogen-activated protein kinase 1 - HPRD 15861134
MAPK3 ERK1 | HS44KDAP |嗡嗡声KER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 mitogen-activated protein kinase 3 - HPRD 15861134
PLAT DKFZp686I03148 | T-PA | TPA plasminogen activator, tissue - HPRD 9268299
PLAU ATF | UPA | URK | UROKINASE | u-PA plasminogen activator, urokinase - HPRD,BioGRID 7721771
SERPINA5 PAI3 | PCI | PLANH3 | PROCI serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 - HPRD,BioGRID 2551064
SERPINE1 PAI | PAI-1 | PAI1 | PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 - HPRD,BioGRID 2110366|8607113
SERPING1 C1IN | C1INH | C1NH | HAE1 | HAE2 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 - HPRD 7586269
SERPINI1 DKFZp781N13156 | PI12 | neuroserpin serpin peptidase inhibitor, clade I (neuroserpin), member 1 - HPRD,BioGRID 12354288
SPARC ON secreted protein, acidic, cysteine-rich (osteonectin) - HPRD 2745554


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG COMPLEMENT AND COAGULATION CASCADES 69 49 All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY 20 13 All SZGR 2.0 genes in this pathway
BIOCARTA FIBRINOLYSIS PATHWAY 12 8 All SZGR 2.0 genes in this pathway
BIOCARTA PLATELETAPP PATHWAY 14 10 All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY 41 32 All SZGR 2.0 genes in this pathway
PID INTEGRIN2 PATHWAY 29 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA UP 74 45 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 44 30 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS DN 120 73 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185 119 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
KERLEY RESPONSE TO CISPLATIN UP 44 30 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP 169 127 All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP 64 45 All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA 39 25 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 57 45 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8P12 P11 AMPLICON 57 32 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC UP 54 30 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP 61 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 64 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP 56 34 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 60 42 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 60 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP 62 35 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
NAKAJIMA MAST CELL 46 34 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 50 34 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 37 31 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C1 19 15 All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 64 44 All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1 58 43 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 0HR 63 48 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9 92 59 All SZGR 2.0 genes in this pathway
TRACEY RESISTANCE TO IFNA2 DN 32 23 All SZGR 2.0 genes in this pathway
SANSOM WNT PATHWAY REQUIRE MYC 58 43 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 36 21 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP 56 36 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL DN 43 28 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 32 20 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 91 63 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442 275 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 89 61 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 109 68 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K4ME3 AND H3K27ME3 34 21 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN 20 17 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207 139 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 140 94 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
STEGER ADIPOGENESIS DN 25 15 All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2 57 39 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238 125 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway