SZGR2 - Beplay体育中心

Summary？

基因	5329
象征	PLAUR
Synonyms	CD87 \| U-PAR \| UPAR \| URKR
Description	纤溶酶原激活剂，尿激酶receptor
Reference	MIM：173391\|HGNC：HGNC：9053\|Ensembl:ENSG00000011422\|HPRD:01421\|Vega：Otthumg00000182778
基因类型	蛋白质编码
Map location	19q13
Pascal p-value	0.365
胎儿β	0.807
主持人	Myers' cis & trans 元

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
rs2682594	CHR19	43940775	PLAUR	5329		0.09		顺式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
ZNF629	0.93	0.94
BAT2L	0.93	0.94
disp2	0.93	0.94
NAV1	0.92	0.94
KIAA1549	0.92	0.94
抽筋1l	0.92	0.93
MFHAS1	0.92	0.94
CAMSAP1	0.92	0.95
FAM123C	0.92	0.93
USP22	0.92	0.95

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
serpinb6	-0.67	-0.75
AF347015.31	-0.66	-0.86
AF347015.27	-0.66	-0.84
MT-CO2	-0.65	-0.86
S100B	-0.65	-0.81
COPZ2	-0.64	-0.78
AF347015.33	-0.64	-0.81
C5orf53	-0.64	-0.72
FXYD1	-0.64	-0.81
HEPN1	-0.63	-0.70

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
EEF1A1	CCS-3 \|CCS3 \|EEF-1 \|EEF1A \|ef-tu \|EF1A \|FLJ25721 \|graf-1ef \|HNGC：16303 \|leng7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	真核翻译伸长因子1 alpha 1	Two-hybrid	Biogrid	16169070
FAP	DKFZP686G13158 \|DPPIV \|FAPA	成纤维细胞激活蛋白，α	-	HPRD,BioGRID	12376466
Fyn	MGC45350 \| SLK \| SYN	Fyn Oncogene与SRC，FGR，是的	-	HPRD	9417082
HCK	JTK9	血压细胞激酶	-	HPRD,BioGRID	11097855
IGF2R	CD222 \| CIMPR \| M6P-R \| MPR1 \| MPRI	insulin-like growth factor 2 receptor	重构的复合物	Biogrid	9566979
itgam	CD11B \| CR3A \| MAC-1 \| MAC1A \| MGC117044 \| MO1A \| SLEB6	integrin, alpha M (complement component 3 receptor 3 subunit)	-	HPRD,BioGRID	10744708
ITGB2	CD18 \|小伙子\|lcamb \|LFA-1 \|Mac-1 \|MF17 \|MFI7	整合素，β2（补体组件3受体3和4亚基）	亲和力捕获 - 韦斯特恩	Biogrid	10388537
JAK1	jak1a \|jak1b \|JTK3	Janus激酶1（蛋白酪氨酸激酶）	-	HPRD,BioGRID	9417082
KNG1	BDK \|kng	差异1	-	HPRD,BioGRID	14764580
LRP1	A2MR \|apoer \|APR \|CD91 \|FLJ16451 \|IGFBP3R \|LRP \|MGC88725 \|TGFBR5	低密度脂蛋白相关蛋白1（Alpha-2-巨球蛋白受体）	-	HPRD,BioGRID	11359936
LRP1B	LRP-DIT \|lrpdit	low density lipoprotein-related protein 1B (deleted in tumors)	-	HPRD	11384978\|12194987
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	An unspecified isoform of PLAUR (uPAR) interacts with PDGFRB.	绑定	15889147
PFN2	D3S1319E \|PFL	profilin 2	Two-hybrid	Biogrid	16169070
PLAU	ATF \| UPA \| URK \| UROKINASE \| u-PA	纤溶酶原激活剂，尿激酶	-	HPRD,BioGRID	3031025\|11501527
PLAU	ATF \| UPA \| URK \| UROKINASE \| u-PA	纤溶酶原激活剂，尿激酶	-	HPRD	11501527
TYK2	JTK1	酪氨酸激酶2	亲和力捕获 - 韦斯特恩	Biogrid	9417082
VTN	V75 \|vn \|vnt	玻霉素	-	HPRD	8830783

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg补充和凝结级联	69	49	All SZGR 2.0 genes in this pathway
PID Integin1途径	66	44	All SZGR 2.0 genes in this pathway
PID Integin3途径	43	25	All SZGR 2.0 genes in this pathway
PID FRA路径	37	28	All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY	15	14	All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY	41	32	All SZGR 2.0 genes in this pathway
PID Integin2途径	29	18	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID INTEGRIN5 PATHWAY	17	9	All SZGR 2.0 genes in this pathway
PID FGF途径	55	37	All SZGR 2.0 genes in this pathway
蛋白质的反应组代谢	518	242	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	26	19	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	188	116	All SZGR 2.0 genes in this pathway
反应组止血	466	331	All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性	351	230	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
周的炎症反应生活	485	293	All SZGR 2.0 genes in this pathway
多恩乳腺癌类DN	34	26	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
Gargalovic对氧化磷脂的反应蓝色	136	80	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出	176	123	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
Kim WT1靶向8小时	164	122	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP	171	112	All SZGR 2.0 genes in this pathway
DMOG的Elvidge缺氧	130	85	All SZGR 2.0 genes in this pathway
Elvidge HIF1A和HIF2A靶向DN	104	72	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP	64	46	All SZGR 2.0 genes in this pathway
kokkinakis蛋氨酸剥夺48小时	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN	508	354	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa Forever DN转变	31	23	All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment	536	340	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP	126	78	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER PROGRESSION UP	9	6	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN	186	107	All SZGR 2.0 genes in this pathway
ZIRN Tretinoin响应WT1 UP	23	14	All SZGR 2.0 genes in this pathway
ZIRN维甲酸响应	21	13	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 6HR	26	15	All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 6HR	19	8	All SZGR 2.0 genes in this pathway
XU HGF TARGETS INDUCED BY AKT1 48HR UP	14	8	All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN	41	33	All SZGR 2.0 genes in this pathway
Gruetzmann胰腺癌	358	245	All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN	38	31	All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 BULK DN	23	15	All SZGR 2.0 genes in this pathway
Hasina NOL7目标	13	11	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT DN	26	19	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向	292	168	All SZGR 2.0 genes in this pathway
Amit EGF响应120 HELA	69	47	All SZGR 2.0 genes in this pathway
Amit EGF响应480 HELA	164	118	All SZGR 2.0 genes in this pathway
Amit EGF响应120 MCF10A	43	28	All SZGR 2.0 genes in this pathway
阿米特血清反应120 MCF10A	65	44	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP	223	140	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
Wong IFNA2电阻DN	34	20	All SZGR 2.0 genes in this pathway
中岛嗜酸性粒细胞	30	20	All SZGR 2.0 genes in this pathway
棕色髓样细胞的发育	165	100	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
Lenaour树突状细胞成熟DN	128	90	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
TACI UP淋巴细胞的淋巴细胞成熟	92	58	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
哈里斯缺氧	81	64	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
Browne HCMV感染48小时DN	504	323	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
麦克拉克兰牙齿龋齿DN	245	144	All SZGR 2.0 genes in this pathway
盖斯对dsrna的响应	38	29	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP	253	147	All SZGR 2.0 genes in this pathway
Bild HRAS致癌特征	261	166	All SZGR 2.0 genes in this pathway
Hillion HMGA1B目标	92	68	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变	180	114	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN	36	21	All SZGR 2.0 genes in this pathway
WILENSKY RESPONSE TO DARAPLADIB	29	20	All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN	108	64	All SZGR 2.0 genes in this pathway
Matthews皮肤致癌作用	17	10	All SZGR 2.0 genes in this pathway
Matthews AP1目标	17	12	All SZGR 2.0 genes in this pathway
冬季缺氧metagene	242	168	All SZGR 2.0 genes in this pathway
Cromer肿瘤发生	63	36	All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记	165	118	All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟A	67	52	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
Chang Core血清反应	212	128	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
池子侵入性乳腺癌	288	168	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Hepatoblast	16	12	All SZGR 2.0 genes in this pathway
woo肝癌复发	105	75	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S1	237	159	All SZGR 2.0 genes in this pathway
由MYC DN监管	253	192	All SZGR 2.0 genes in this pathway
Browne HCMV感染2小时DN	49	33	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
Hirsch细胞转换签名	242	159	All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应	549	316	All SZGR 2.0 genes in this pathway
Delpuech FOXO3靶向	68	49	All SZGR 2.0 genes in this pathway
BMI1和PCGF2的Wiederschain目标	57	39	All SZGR 2.0 genes in this pathway
Winzen通过KHSRP退化	100	70	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7	403	240	All SZGR 2.0 genes in this pathway
ERBB2的611CTF同工型的PEDERSEN目标	76	45	All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时	199	143	All SZGR 2.0 genes in this pathway
通过KDM3A的Krieg缺氧	53	34	All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS	239	156	All SZGR 2.0 genes in this pathway
通过p38部分的phong TNF响应	160	106	All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38	337	236	All SZGR 2.0 genes in this pathway
Altemeier对LPS具有机械通气的反应	128	81	All SZGR 2.0 genes in this pathway
前列腺癌模型中的Acevedo FGFR1靶标	289	184	All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导	222	159	All SZGR 2.0 genes in this pathway

Gene Page:PLAUR