Gene Page:LRP1B

概括?
基因 53353
Symbol LRP1B
Synonyms LRP-DIT|LRPDIT
Description LDL receptor related protein 1B
Reference MIM:608766|HGNC:HGNC:6693|ENSEMBL：ENSG00000168702|HPRD:16383|Vega:OTTHUMG00000131799
Gene type protein-coding
Map location 2q21.2
Sherlock p-value 0.119
Fetal beta -0.335
DMG 1 (# studies)
eGene Putamen basal ganglia

数据源中的基因
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.023
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02395
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02322989 2 142888598 LRP1B -0.026 0.34 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10211565 2 142889154 LRP1B ENSG00000168702.12 2.18965E-6 0.03 116 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去你rm Evidence Neuro keywords PubMed ID
GO:0005041 low-density lipoprotein receptor activity IEA -
GO:0004872 receptor activity IEA -
GO:0005509 calcium ion binding IEA -
GO:0005515 protein binding IEA -
生物过程 去你rm Evidence Neuro keywords PubMed ID
GO:0006898 receptor-mediated endocytosis TAS 10766186
GO:0015031 protein transport TAS 10766186
Cellular component 去你rm Evidence Neuro keywords PubMed ID
GO:0005624 membrane fraction IEA -
去：0016020 membrane IEA -
GO：0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DELYS THYROID CANCER DN 232 154 该途径中的所有SZGR 2.0基因
ROVERSI GLIOMA COPY NUMBER DN 54 37 该途径中的所有SZGR 2.0基因
SILIGAN BOUND BY EWS FLT1 FUSION 47 34 该途径中的所有SZGR 2.0基因
MOHANKUMAR TLX1 TARGETS DN 193 112 该途径中的所有SZGR 2.0基因
DING LUNG CANCER MUTATED SIGNIFICANTLY 26 22 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN 1237 837 该途径中的所有SZGR 2.0基因
ULE SPLICING VIA NOVA2 43 38 该途径中的所有SZGR 2.0基因
DOUGLAS BMI1 TARGETS DN 314 188 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER RELAPSE IN BONE UP 97 61 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL UP 260 174 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 该途径中的所有SZGR 2.0基因
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 77 52 该途径中的所有SZGR 2.0基因
DING LUNG CANCER BY MUTATION RATE 20 18 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 231 237 m8 HSA-MIR-103brain AGCAGCAUUGUACAGGGCUAUGA
HSA-MIR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-130/301 207 213 1A hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p 1711 1718 1A,m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
mir-15/16/195/424/497 232 238 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-155 1447 1454 1A,m8 hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-183 1524 1530 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-196 1505 1512 1A,m8 hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-200bc/429 66 73 1A,m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-214 234 240 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-330 524 531 1A,m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-361 1353 1359 m8 hsa-miR-361brain UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p 68 75 1A,m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
mir-374 69 75 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
mir-493-5p 1441 1447 1A hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-494 1686年 1692年 m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
mir-495 258 264 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-543 1586 1592 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU