Gene Page:PLCG2
Summary?
基因 | 5336 |
象征 | PLCG2 |
Synonyms | APLAID|FCAS3|PLC-IV|PLC-gamma-2 |
Description | 磷脂酶C伽马2 |
Reference | MIM:600220|HGNC:HGNC:9066|Ensembl:ENSG00000197943|HPRD:02570|Vega:OTTHUMG00000176532 |
基因类型 | 蛋白质编码 |
Map location | 16q24.1 |
Pascal p-value | 0.362 |
胎儿β | -0.512 |
主持人 | Caudate basal ganglia Putamen basal ganglia |
Gene in Data Sources
基因集名称 | Method of gene set | Description | 信息 |
---|---|---|---|
CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
---|---|---|---|---|---|---|---|---|
RS4468612 | 16 | 81861556 | PLCG2 | ENSG00000197943.5 | 6.67944e-7 | 0 | 48693 | gtex_brain_putamen_basal |
RS11645217 | 16 | 81867338 | PLCG2 | ENSG00000197943.5 | 5.44893E-7 | 0 | 54475 | gtex_brain_putamen_basal |
RS4258607 | 16 | 81867410 | PLCG2 | ENSG00000197943.5 | 9.72192E-9 | 0 | 54547 | gtex_brain_putamen_basal |
rs72832055 | 16 | 81869387 | PLCG2 | ENSG00000197943.5 | 4.3735E-9 | 0 | 56524 | gtex_brain_putamen_basal |
RS61374069 | 16 | 81874200 | PLCG2 | ENSG00000197943.5 | 1.39027E-9 | 0 | 61337 | gtex_brain_putamen_basal |
RS12599660 | 16 | 81875131 | PLCG2 | ENSG00000197943.5 | 1.00355E-10 | 0 | 62268 | gtex_brain_putamen_basal |
RS8043593 | 16 | 81876279 | PLCG2 | ENSG00000197943.5 | 3.56153E-11 | 0 | 63416 | gtex_brain_putamen_basal |
rs67823242 | 16 | 81876369 | PLCG2 | ENSG00000197943.5 | 6.87651E-11 | 0 | 63506 | gtex_brain_putamen_basal |
rs72832062 | 16 | 81877470 | PLCG2 | ENSG00000197943.5 | 3.32294E-10 | 0 | 64607 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达(GTEX)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/PLCG2_DE_GTEx.png)
Devlopment期间的基因表达(BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
Footnote:
SC:分皮质区域;SM:感觉运动区域s; FC: frontal cortex; and TP: temporal-parietal cortex
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。
大脑区域的顶级共表达基因
前10个积极共表达的基因 | ||
Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
MAP1LC3A | 0.77 | 0.80 |
TFR2 | 0.76 | 0.79 |
Fabp3 | 0.74 | 0.82 |
B4GALT2 | 0.73 | 0.72 |
PAK6 | 0.72 | 0.75 |
GNG3 | 0.72 | 0.78 |
NGB | 0.72 | 0.70 |
SPATA2L | 0.72 | 0.75 |
LEPREL2 | 0.71 | 0.81 |
DEAF1 | 0.71 | 0.77 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
AF347015.2 | -0.37 | -0.34 |
AF347015.26 | -0.37 | -0.36 |
PLXNB1 | -0.36 | -0.38 |
AF347015.18 | -0.35 | -0.35 |
AF347015.8 | -0.34 | -0.32 |
mt-cyb | -0.33 | -0.32 |
AF347015.33 | -0.33 | -0.32 |
AF347015.15 | -0.33 | -0.31 |
AL139819.3 | -0.32 | -0.32 |
AIF1L | -0.32 | -0.35 |
Section IV. Protein-protein interaction annotation
互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
---|---|---|---|---|---|
BLK | MGC10442 | B淋巴酪氨酸激酶 | - | HPRD,BioGRID | 8395016 |
BLNK | bash |blnk-s |Ly57 |MGC111051 |SLP-65 |SLP65 | B细胞链接器 | - | HPRD | 11274146 |
btk | AGMX1 |在|ATK |bpk |IMD1 |MGC126261 |MGC126262 |PSCTK1 |XLA | 布鲁顿阿氨基葡萄糖酸酪氨酸激酶 | 亲和力捕获 - 韦斯特恩 | Biogrid | 10981967|12093870 |
CBLB | DKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56 | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | - | HPRD,BioGRID | 12093870 |
FCER1G | FCRG | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | - | HPRD,BioGRID | 10469124 |
FLT1 | flt |VEGFR1 | 与FMS相关的酪氨酸激酶1(血管内皮生长因子/血管通透性因子受体) | - | HPRD | 9398617 |
Fyn | MGC45350 | SLK | SYN | Fyn Oncogene与SRC,FGR,是的 | - | HPRD,BioGRID | 8395016 |
GAB1 | - | GRB2-associated binding protein 1 | - | HPRD | 11507676 |
GAB2 | KIAA0571 | GRB2-associated binding protein 2 | - | HPRD,BioGRID | 12135708 |
KDR | CD309 |flk1 |VEGFR |VEGFR2 | 激酶插入结构域受体(III型受体酪氨酸激酶) | - | HPRD | 9398617 |
KHDRBS1 | FLJ34027 | Sam68 | p62 | KH结构域含有RNA结合,信号转导相关1 | - | HPRD | 10467411 |
拉特 | 拉特1 | pp36 | 激活T细胞的接头 | - | HPRD,BioGRID | 10469124 |
拉特2 | HSPC046 |实验室|ntal |WBSCR15 |WBSCR5 |WSCR5 | 激活T细胞的接头family, member 2 | - | HPRD,BioGRID | 12514734 |
LCP2 | SLP-76 |SLP76 | 淋巴细胞胞质蛋白2(含有76KDA的白细胞蛋白的SH2结构域) | - | HPRD,BioGRID | 10469124 |
林恩 | FLJ26625 | JTK8 | V-YES-1 Yamaguchi肉瘤病毒相关的癌基因同源物 | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 8395016|10981967 |
PLCG1 | PLC-II |PLC1 |PLC148 |Plcgamma1 | 磷脂酶C,伽马1 | - | HPRD | 8885868 |
PRKD1 | PKC-MU | PKCM | PKD | PRKCM | 蛋白激酶D1 | - | HPRD,BioGRID | 8885868 |
PTPN11 | bptp3 |CFC |MGC14433 |NS1 |PTP-1D |PTP2C |SH-PTP2 |sh-ptp3 |SHP2 | protein tyrosine phosphatase, non-receptor type 11 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12135708 |
SH3BP2 | 3BP2 |CRBM |CRPM |FLJ42079 |RES4-23 | SH3膜结合蛋白2 | - | HPRD | 11390470 |
SHC1 | FLJ26504 | SHC | SHCA | SHC(SRC同源性2结构域)转化蛋白1 | - | HPRD,BioGRID | 10623845 |
SYK | DKFZp313N1010 | FLJ25043 | FLJ37489 | 脾酪氨酸激酶 | 亲和力捕获 - 韦斯特恩 | Biogrid | 10981967 |
VAV1 | VAV | VAV 1鸟嘌呤核苷酸交换因子 | 亲和力捕获 - 韦斯特恩 | Biogrid | 10981967 |