Gene Page:PLD2

Summary?
GeneID 5338
Symbol PLD2
Synonyms -
Description 磷脂酶D2
Reference MIM:602384|HGNC:HGNC:9068|Ensembl:ENSG00000129219|HPRD:03857|Vega:OTTHUMG00000090779
Gene type protein-coding
Map location 17p13.1
Pascal p-value 0.207
Sherlock p-value 0.268
Fetal beta 0.229
DMG 2 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23956071 17 4710044 PLD2 1.131E-4 -0.367 0.029 DMG:Wockner_2014
cg16685860 17 4710619 PLD2 -0.03 0.46 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL类型
rs1038121 chr17 4475243 PLD2 5338 0.12 cis
rs1038118 chr17 4475583 PLD2 5338 0.14 cis
rs16905508 chr8 137113905 PLD2 5338 0.08 trans
rs11785077 chr8 137115681 PLD2 5338 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTB PS1TP5BP1 肌动蛋白,β - HPRD 11373276
ALDOA ALDA | MGC10942 | MGC17716 | MGC17767 “肾上腺脑白质退化症”olase A, fructose-bisphosphate - HPRD,BioGRID 11876650
AMPH AMPH1 amphiphysin - HPRD,BioGRID 10764771
AQP3 GIL aquaporin 3 (Gill blood group) - HPRD,BioGRID 14675200
ARF1 - ADP-ribosylation factor 1 Reconstituted Complex BioGRID 10801846|11373276
ARF1 - ADP-ribosylation factor 1 - HPRD 10801846|12519790
BIN1 AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9 bridging integrator 1 - HPRD,BioGRID 10764771
CAV1 CAV | MSTP085 | VIP21 caveolin 1, caveolae protein, 22kDa - HPRD,BioGRID 10675563
CAV2 CAV | MGC12294 2窖蛋白 Co-fractionation BioGRID 10675563
CSK MGC117393 c-src tyrosine kinase - HPRD 12697812
EGFR ERBB | ERBB1 | HER1 | PIG61 | mENA epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) - HPRD,BioGRID 9837959
EGFR ERBB | ERBB1 | HER1 | PIG61 | mENA epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) EGFR interacts with PLD1. This interaction was modelled on a demonstrated interaction between human EGFR and mouse PLD2. BIND 9837959
FRAP1 FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1 FK506 binding protein 12-rapamycin associated protein 1 Affinity Capture-Western BioGRID 16837165
FYN MGC45350 | SLK | SYN FYN oncogene related to SRC, FGR, YES - HPRD 12697812
GAPDH G3PD | GAPD | MGC88685 glyceraldehyde-3-phosphate dehydrogenase - HPRD,BioGRID 12753082
GM2A SAP-3 GM2 ganglioside activator - HPRD 11672434
KIAA1303 - raptor Affinity Capture-Western BioGRID 16837165
LCK YT16 | p56lck | pp58lck lymphocyte-specific protein tyrosine kinase - HPRD 12697812
OPRM1 KIAA0403 | MOR | MOR1 | OPRM opioid receptor, mu 1 - HPRD,BioGRID 12519790
PEA15 HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PED phosphoprotein enriched in astrocytes 15 - HPRD,BioGRID 10926929
PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase, type I, alpha - HPRD 11032811
PLCG1 PLC-II | PLC1 | PLC148 | PLCgamma1 phospholipase C, gamma 1 - HPRD,BioGRID 12646582
PLCG1 PLC-II | PLC1 | PLC148 | PLCgamma1 phospholipase C, gamma 1 PLC-gamma1 interacts with PLD2. This interaction was modeled on a demonstrated interaction between PLC-gamma1 from an unspecified species and human PLD2. BIND 14744865
PRKCA AAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACA protein kinase C, alpha - HPRD,BioGRID 11042115
PRKCD MAY1 | MGC49908 | PKCD | nPKC-delta protein kinase C, delta - HPRD,BioGRID 11744693
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		 BioGRID 12697812


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCEROPHOSPHOLIPID METABOLISM 77 35 All SZGR 2.0 genes in this pathway
KEGG ETHER LIPID METABOLISM 33 15 All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY 23 16 All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY 28 22 All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY 37 32 All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 62 43 All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 45 33 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 49 34 All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 50 41 All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 15 14 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 34 26 All SZGR 2.0 genes in this pathway
PID ARF 3PATHWAY 19 13 All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 33 25 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198 112 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PA 27 14 All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 82 39 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185 114 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 17P13 DELETION 21 15 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425 261 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 92 60 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 107 72 All SZGR 2.0 genes in this pathway