Gene Page:ATP6V1G2
Summary?
| GeneID | 534 |
| Symbol | ATP6V1G2 |
| Synonyms | ATP6G|ATP6G2|NG38|VMA10 |
| Description | ATPase H+ transporting V1 subunit G2 |
| Reference | MIM:606853|HGNC:HGNC:862|Ensembl:ENSG00000213760|HPRD:06030|Vega:OTTHUMG00000166618 |
| Gene type | protein-coding |
| Map location | 6p21.3 |
| Pascal p-value | 9.718E-6 |
| Sherlock p-value | 0.947 |
| Support | ION BALANCE CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SEZ6L2 | 0.93 | 0.94 |
| ACP2 | 0.91 | 0.91 |
| GPI | 0.91 | 0.89 |
| SLC45A1 | 0.90 | 0.91 |
| PCYOX1L | 0.90 | 0.88 |
| CLSTN3 | 0.90 | 0.93 |
| SLC27A4 | 0.90 | 0.93 |
| ENO2 | 0.90 | 0.89 |
| AP2A1 | 0.90 | 0.90 |
| SV2A | 0.89 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.60 | -0.46 |
| AP002478.3 | -0.57 | -0.52 |
| AF347015.18 | -0.57 | -0.47 |
| NOSTRIN | -0.56 | -0.45 |
| GNG11 | -0.56 | -0.50 |
| MT-CO2 | -0.56 | -0.44 |
| AC098691.2 | -0.54 | -0.48 |
| AF347015.31 | -0.54 | -0.43 |
| AF347015.2 | -0.54 | -0.39 |
| AF347015.8 | -0.53 | -0.42 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IEA | - | |
| GO:0005515 | protein binding | 知识产权I | 14667819 | |
| GO:0016787 | hydrolase activity | IEA | - | |
| GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism | IEA | - | |
| 去:0016887 | ATPase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006811 | ion transport | IEA | - | |
| GO:0015992 | proton transport | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0030285 | integral to synaptic vesicle membrane | IEA | Synap (GO term level: 14) | - |
| GO:0016471 | vacuolar proton-transporting V-type ATPase complex | IEA | - | |
| GO:0042470 | melanosome | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG OXIDATIVE PHOSPHORYLATION | 135 | 73 | All SZGR 2.0 genes in this pathway |
| KEGG霍乱弧菌感染 | 56 | 32 | All SZGR 2.0 genes in this pathway |
| KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | 68 | 44 | All SZGR 2.0 genes in this pathway |
| REACTOME INSULIN RECEPTOR RECYCLING | 23 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | 33 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME IRON UPTAKE AND TRANSPORT | 36 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | 25 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY INSULIN RECEPTOR | 108 | 72 | All SZGR 2.0 genes in this pathway |
| LU AGING BRAIN DN | 153 | 120 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| LEIN NEURON MARKERS | 69 | 45 | All SZGR 2.0 genes in this pathway |
| MEISSNER ES ICP WITH H3K4ME3 | 34 | 17 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC ICP WITH H3K4ME3 | 20 | 9 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN ICP WITH H3K4ME3 | 32 | 17 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 | 73 | 37 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| ROESSLER LIVER CANCER METASTASIS DN | 53 | 29 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |