SZGR2 - Beplay体育中心

Summary？

基因	5340
象征	PLG
Synonyms	-
Description	纤溶酶原
Reference	MIM:173350\|HGNC：HGNC：9071\|Ensembl:ENSG00000122194\|HPRD:01417\|Vega:OTTHUMG00000015957
基因类型	蛋白质编码
Map location	6q26
Pascal p-value	0.037
胎儿β	0.028

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症	点击显示详细信息
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.0033

Section I. Genetics and epigenetics annotation

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene	Pearson's Correlation	斯皮尔曼的相关性
mettl11a	0.90	0.89
C19orf62	0.88	0.88
AP2S1	0.88	0.87
TIMM50	0.88	0.85
MANBAL	0.87	0.84
CDK5	0.87	0.84
TSFM	0.87	0.82
fibp	0.86	0.85
ASNA1	0.86	0.83
FLOT1	0.85	0.84

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	斯皮尔曼的相关性
AF347015.18	-0.58	-0.43
AF347015.26	-0.56	-0.41
AF347015.2	-0.54	-0.37
AF347015.8	-0.49	-0.34
AF347015.15	-0.48	-0.34
MT-CO2	-0.47	-0.30
mt-cyb	-0.47	-0.33
AC010300.1	-0.47	-0.47
AC016705.1	-0.47	-0.40
AL139819.3	-0.47	-0.39

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0004252	serine-type endopeptidase activity	TAS	glutamate (GO term level: 7)	9242524
去：0005509	calcium ion binding	IEA		-
去：0008233	肽酶活性	IEA		-
GO：0034185	apolipoprotein binding	IPI		16480936
生物过程	去学期	证据	神经关键字	PubMed ID
去：0006508	proteolysis	IEA		-
GO:0006917	诱导凋亡	IEA		-
GO:0006917	诱导凋亡	TAS		11257124
GO:0008285	negative regulation of cell proliferation	TAS		8910613
去：0007596	血液凝血	IMP		1986355
GO:0006915	凋亡	IEA		-
GO:0042246	tissue regeneration	IEA		-
GO：0016525	血管生成的阴性调节	TAS		11257124
GO：0043537	血管内皮细胞迁移的阴性调节	TAS		11257124
GO:0046716	muscle maintenance	IEA		-
GO:0045445	成肌细胞差异	IEA		-
GO:0048771	组织重塑	IEA		-
GO:0051918	negative regulation of fibrinolysis	IDA		14726399
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005576	细胞外区域	经验		2318848\|2962641
去：0005576	细胞外区域	IEA		-
去：0005615	细胞外空间	IDA		6216475

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ACTG1	行为\|ACTG \|DFNA20 \|DFNA26	肌动蛋白，伽马1	PLGinteracts with ACTG1 (G-actin). This interaction was modelled on a demonstrated interaction between human PLG and bovine ACTG1.	绑定	15746964
AMOT	KIAA1071	血管敏	-	HPRD	11257124
anxa2	Anx2 \|Anx2l4 \|cal1h \|lip2 \|LPC2 \|LPC2D \|p36 \|PAP-IV	annexin A2	-	HPRD	10077593
ATP5B	ATPMB \|atpsb \|MGC5231	ATP合酶，H+转运，线粒体F1复合物，β多肽	-	HPRD	10077593
C7	-	complement component 7	-	HPRD,BioGRID	7814888
CHGA	CGA	chromogranin A (parathyroid secretory protein 1)	-	HPRD,BioGRID	11342539
CLEC3B	DKFZP686H17246 \|TN \|TNA	C-type lectin domain family 3, member B	-	HPRD	10964919
CPB2	CPU \| PCPB \| TAFI	carboxypeptidase B2 (plasma)	-	HPRD,BioGRID	1939207
CXCL2	CINC-2A \|gro2 \|grob \|mgsa-b \|MIP-2A \|MIP2 \|mip2a \|scyb2	chemokine (C-X-C motif) ligand 2	-	HPRD,BioGRID	10928473
ENO1	eno1l1 \|MBP-1 \|MPB1 \|nne \|pph	enolase 1, (alpha)	重构的复合物	Biogrid	11169399
F10	FX \| FXA	凝结因子x	-	HPRD,BioGRID	11371191
F3	CD142 \|TF \|TFA	凝血因子III（血小板素，组织因子）	-	HPRD,BioGRID	9490681
HMGB1	DKFZP686A04236 \|HMG1 \|HMG3 \|SBP-1	高机动性组框1	-	HPRD,BioGRID	1909331
HRG	DKFZP779H1622 \|HPRG \|HRGP	富含组氨酸的糖蛋白	-	HPRD	8478593
IGFBP3	BP-53 \|IBP3	胰岛素样生长因子结合蛋白3	-	HPRD,BioGRID	9688635
KNG1	BDK \|kng	差异1	-	HPRD,BioGRID	9428707
喇嘛1	喇嘛	laminin, alpha 1	-	HPRD,BioGRID	8360181
喇嘛3	BM600 \|E170 \|lamna \|locs \|Lama3a	laminin, alpha 3	-	HPRD	10956663
喇嘛5	KIAA1907	laminin, alpha 5	重构的复合物	Biogrid	10956663
NGF	Beta-NGF \| HSAN5 \| MGC161426 \| MGC161428 \| NGFB	nerve growth factor (beta polypeptide)	-	HPRD	11729324
帕帕	asbabp2 \|Dipla1 \|IGFBP-4ase \|爸爸\|PAPP-A \|Pappa1	妊娠相关血浆蛋白A，Pappalysin 1	生化活动	Biogrid	7586586
PLAU	ATF \| UPA \| URK \| UROKINASE \| u-PA	纤溶酶原激活剂，尿激酶	-	HPRD	2829380\|3920216
PRNP	ASCR \| CD230 \|库贾氏症\| GSS \| MGC26679 \| PRIP \| PrP \|PrP27-30 \| PrP33-35C \| PrPc \| prion	prion protein	PRPSC与PLG相互作用。	绑定	11438139
S100A10	42c \|Anx2l \|Anx2lg \|cal1l \|Clp11 \|CA [1] \|GP11 \|MGC111133 \|P11 \|P10	S100钙结合蛋白A10	-	HPRD,BioGRID	11939791
serpinc1	AT3 \| ATIII \| MGC22579	serpin peptidase inhibitor, clade C (antithrombin), member 1	-	HPRD	10974350
serpine1	pai \|pai-1 \|pai1 \|PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	重构的复合物	Biogrid	11113116
serpinf2	A2AP \| AAP \| ALPHA-2-PI \| API \| PLI	SERPIN肽酶抑制剂，进化枝F（α-2抗刺蛋白，色素上皮衍生因子），成员2	-	HPRD,BioGRID	158022\|2437112 \|3334852
Sparc	上	分泌的蛋白质，酸性，富含半胱氨酸的蛋白质（骨蛋白）	-	HPRD,BioGRID	2745554\|7982919
TFPI2	FLJ21164 \|pp5 \|Ref1 \|TFPI-2	组织因子途径抑制剂2	-	HPRD	8555184
THBS1	THBS \| TSP \| TSP1	thrombospondin 1	-	HPRD,BioGRID	2522013

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
kegg补充和凝结级联	69	49	All SZGR 2.0 genes in this pathway
BIOCARTA AMI PATHWAY	20	13	All SZGR 2.0 genes in this pathway
BIOCARTA FIBRINOLYSIS PATHWAY	12	8	All SZGR 2.0 genes in this pathway
Biocarta血小板途径	14	10	All SZGR 2.0 genes in this pathway
PID血管生成素受体途径	50	41	All SZGR 2.0 genes in this pathway
PID P75 NTR途径	69	51	All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY	41	32	All SZGR 2.0 genes in this pathway
PID Syndecan 4途径	32	25	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
细胞外基质的反应组降解	29	11	All SZGR 2.0 genes in this pathway
REACTOME EXTRACELLULAR MATRIX ORGANIZATION	87	42	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
Reactome糖尿病途径	133	91	All SZGR 2.0 genes in this pathway
胰岛素像生长因子结合蛋白IGFBPS对胰岛素类似生长因子IGF活性的反应组调节	16	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
反应组止血	466	331	All SZGR 2.0 genes in this pathway
Reactome血小板激活信号传导和聚集	208	138	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN	514	319	All SZGR 2.0 genes in this pathway
RANKIN ANGIOGENIC TARGETS OF VHL HIF2A UP	5	5	All SZGR 2.0 genes in this pathway
弗莱赫纳活检肾脏移植被拒绝vs ok dn	546	351	All SZGR 2.0 genes in this pathway
棕色髓样细胞的发育	165	100	All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES	244	154	All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS DIRECT UP	27	21	All SZGR 2.0 genes in this pathway
XU GH1外源目标DN	120	69	All SZGR 2.0 genes in this pathway
由FOXP3绑定的Marson刺激	1022	619	All SZGR 2.0 genes in this pathway
李肝癌	49	29	All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION DN	60	38	All SZGR 2.0 genes in this pathway
阿塞维多肝癌DN	540	340	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN	274	165	All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化	940	425	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
Labbe TGFB1靶向	102	64	All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN	138	92	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
Chang Core血清反应	212	128	All SZGR 2.0 genes in this pathway
清肝癌亚类增殖DN	179	97	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP	85	50	All SZGR 2.0 genes in this pathway
Hoshida肝癌生存DN	113	76	All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S3	266	180	All SZGR 2.0 genes in this pathway
开罗肝脏发展DN	222	141	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向	504	321	All SZGR 2.0 genes in this pathway
Servitja肝HNF1A靶向DN	157	105	All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上	1839	928	All SZGR 2.0 genes in this pathway
NABA ECM监管机构	238	125	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Gene Page:PLG