Gene Page:PLK1

Summary?
GeneID 5347
Symbol PLK1
Synonyms PLK|STPK13
Description polo like kinase 1
Reference MIM:602098|HGNC:HGNC:9077|Ensembl:ENSG00000166851|HPRD:03652|Vega:OTTHUMG00000096984
Gene type protein-coding
Map location 16p12.2
Pascal p-value 0.159
Fetal beta -0.129
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775

部分即遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06240124 16 23690079 PLK1 4.4E-9 -0.024 2.6E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 12493754|15070733|15654075
|16439210|18329369
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0004674 protein serine/threonine kinase activity TAS 8127874
GO:0016740 transferase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007049 cell cycle IEA -
GO:0007067 mitosis TAS 9177283
GO:0008283 cell proliferation TAS 8127874
GO:0051301 cell division IEA -
GO:0051437 positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle EXP 10793135
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005813 centrosome IDA 11256614
GO:0005829 cytosol EXP 15678101
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm EXP 11897663|12738781|12939256
|15148369|15199097
|15469984

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ASPM ASP | Calmbp1 | DKFZp686N06184 | FLJ10517 | FLJ10549 | FLJ43117 | MCPH5 asp (abnormal spindle) homolog, microcephaly associated (Drosophila) - HPRD 11283617
BRCA2 BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1 breast cancer 2, early onset Affinity Capture-Western
Reconstituted Complex		 BioGRID 12815053|14647413
C7orf20 CEE | CGI-20 chromosome 7 open reading frame 20 Two-hybrid BioGRID 16169070
CDC25C CDC25 cell division cycle 25 homolog C (S. pombe) - HPRD,BioGRID 11202906
CDC25C CDC25 cell division cycle 25 homolog C (S. pombe) Plk1磷酸化CDC2同种型不详5C. This interaction was modeled on a demonstrated phosphorylation of CDC25C from an unspecified species by human Plk1. BIND 15766665
CHEK2 CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53 CHK2 checkpoint homolog (S. pombe) - HPRD,BioGRID 12493754
DCTN1 DAP-150 | DP-150 | HMN7B | P135 dynactin 1 (p150, glued homolog, Drosophila) Affinity Capture-Western BioGRID 12852857
DNAJB9 DKFZp564F1862 | ERdj4 | MDG1 | MST049 | MSTP049 DnaJ (Hsp40) homolog, subfamily B, member 9 Two-hybrid BioGRID 16169070
GORASP1 FLJ23443 | GOLPH5 | GRASP65 | MGC118894 | MGC118897 | P65 golgi reassembly stacking protein 1, 65kDa - HPRD 11447294
KIF23 CHO1 | KNSL5 | MKLP-1 | MKLP1 kinesin family member 23 - HPRD 8524282
MAGED1 DLXIN-1 | NRAGE melanoma antigen family D, 1 Two-hybrid BioGRID 16169070
NPM1 B23 | MGC104254 | NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) - HPRD 15190079
NUDC HNUDC | MNUDC | NPD011 nuclear distribution gene C homolog (A. nidulans) - HPRD,BioGRID 12852857
PIN1 DOD | UBL5 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 - HPRD,BioGRID 9499405
PIN1 DOD | UBL5 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Pin1 interacts with PLK1. BIND 9499405
PITPNM1 DRES9 | FLJ44997 | NIR2 | PITPNM | RDGB | RDGB1 | RDGBA | RDGBA1 | Rd9 phosphatidylinositol transfer protein, membrane-associated 1 Nir2 interacts with Plk1. BIND 15125835
PSMA1 HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30 proteasome (prosome, macropain) subunit, alpha type, 1 Affinity Capture-Western BioGRID 11205743
PSMA2 HC3 | MU | PMSA2 | PSC2 proteasome (prosome, macropain) subunit, alpha type, 2 Affinity Capture-MS BioGRID 11205743
PSMA3 HC8 | MGC12306 | MGC32631 | PSC3 proteasome (prosome, macropain) subunit, alpha type, 3 - HPRD,BioGRID 11205743
PSMA4 HC9 | HsT17706 | MGC111191 | MGC12467 | MGC24813 | PSC9 proteasome (prosome, macropain) subunit, alpha type, 4 - HPRD,BioGRID 11205743
PSMA5 MGC117302 | MGC125802 | MGC125803 | MGC125804 | PSC5 | ZETA proteasome (prosome, macropain) subunit, alpha type, 5 - HPRD,BioGRID 11205743
PSMA6 IOTA | MGC22756 | MGC2333 | MGC23846 | PROS27 | p27K proteasome (prosome, macropain) subunit, alpha type, 6 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11205743
PSMA7 C6 | HSPC | MGC3755 | RC6-1 | XAPC7 proteasome (prosome, macropain) subunit, alpha type, 7 - HPRD,BioGRID 11205743
PSMB1 FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5 proteasome (prosome, macropain) subunit, beta type, 1 - HPRD,BioGRID 11205743
PSMB3 HC10-II | MGC4147 proteasome (prosome, macropain) subunit, beta type, 3 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11205743
PSMB5 LMPX | MB1 | MGC104214 | X proteasome (prosome, macropain) subunit, beta type, 5 Affinity Capture-Western BioGRID 11205743
PSMB6 DELTA | LMPY | MGC5169 | Y proteasome (prosome, macropain) subunit, beta type, 6 Affinity Capture-Western BioGRID 11205743
PSMB7 Z proteasome (prosome, macropain) subunit, beta type, 7 Affinity Capture-Western BioGRID 11205743
RECQL5 FLJ90603 | RECQ5 RecQ protein-like 5 Two-hybrid BioGRID 16169070
TSC1 KIAA0243 | LAM | MGC86987 | TSC tuberous sclerosis 1 Affinity Capture-Western BioGRID 16339216
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 Affinity Capture-Western BioGRID 16339216
WEE1 DKFZp686I18166 | FLJ16446 | WEE1A | WEE1hu WEE1 homolog (S. pombe) Wee1A interacts with and is phophorylated by Plk1. This interaction was modeled on a demonstrated interaction between human Wee1A and mouse Plk1. BIND 15070733


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 114 79 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY 24 20 All SZGR 2.0 genes in this pathway
PID P73PATHWAY 79 59 All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 39 25 All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY 46 25 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY 40 30 All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY 54 40 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 66 43 All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 59 38 All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 15 8 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 85 46 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 81 50 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 72 38 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 87 51 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF THE APC C 23 10 All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 151 84 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN 53 25 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 139 76 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN 172 112 All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP 58 44 All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN 49 33 All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 97 58 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 140 73 All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP 64 45 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR DN 20 12 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149 101 All SZGR 2.0 genes in this pathway
KARAKAS TGFB1 SIGNALING 18 15 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP 108 75 All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 76 57 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP 42 26 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234 137 All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL DN 25 16 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE DN 11 9 All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP 54 33 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3 101 64 All SZGR 2.0 genes in this pathway
LY AGING OLD DN 56 35 All SZGR 2.0 genes in this pathway
LY AGING MIDDLE DN 16 10 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6 91 44 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESPONSE 40 25 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME RED 16 11 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180 114 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 79 45 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
FIRESTEIN CTNNB1 PATHWAY 33 23 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
我IBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 148 83 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356 214 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN 98 69 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN 72 47 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE 44 25 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
WANG METASTASIS OF BREAST CANCER ESR1 UP 22 14 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有年代的目标ATB1 UP 344 215 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
REICHERT MITOSIS LIN9 TARGETS 28 17 All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 114 69 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway