Gene Page:PLP1

Summary?
GeneID 5354
Symbol PLP1
Synonyms GPM6C|HLD1|MMPL|PLP|PLP/DM20|PMD|SPG2
Description proteolipid protein 1
Reference MIM:300401|HGNC:HGNC:9086|Ensembl:ENSG00000123560|HPRD:02321|Vega:OTTHUMG00000022111
Gene type protein-coding
Map location Xq22
Sherlock p-value 0.126
Fetal beta -3.785
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanARC
G2Cdb.humanNRC
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
Literature High-throughput literature-search Co-occurance与精神分裂症nia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0005198 structural molecule activity TAS 2479017
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0022010 myelination in the central nervous system IEA neuron, axon, oligodendrocyte, dendrite (GO term level: 14) -
GO:0008366 axon ensheathment TAS neuron, axon (GO term level: 12) 2479017
GO:0007268 synaptic transmission TAS neuron, Synap, Neurotransmitter (GO term level: 6) 2479017
GO:0048469 cell maturation IEA -
GO:0042759 long-chain fatty acid biosynthetic process IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0043209 myelin sheath IEA neuron, axon, oligodendrocyte, Glial (GO term level: 7) -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 175 82 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID UP 45 26 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN 39 27 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
JOHANSSON BRAIN CANCER EARLY VS LATE DN 45 35 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200 112 All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS 74 41 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185 111 All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION 40 29 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 141 99 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS DN 61 47 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
NIELSEN SCHWANNOMA UP 18 16 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 82 55 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS 108 68 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM PTEN TARGETS UP 18 9 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-140 41 47 1A hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-146 2010 2016 1A hsa-miR-146a UGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrain UGAGAACUGAAUUCCAUAGGCU
miR-186 1130 1136 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-26 111 117 m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-29 986 992 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-361 1908 1914 m8 hsa-miR-361brain UUAUCAGAAUCUCCAGGGGUAC
miR-362 572 578 m8 hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-543 2006 2012 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU