Summary
基因 5362
象征 PLXNA2
Synonyms OCT | PLXN2
Description plexin A2
Reference MIM:601054|HGNC:HGNC:9100|Ensembl:ENSG00000076356|HPRD:03033|Vega:Otthumg0000000036564
基因类型 蛋白质编码
地图位置 1q32.2
Sherlock p-value 0.275
胎儿β 1.239
主持人 前扣带回皮层BA24
支持 G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet
Darnell FMRP目标

基因in Data Sources
基因集名称 基因组方法 Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
简历:PGCNP 全基因组协会研究 GWAS
PMID:cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
协会 A combined odds ratio method (Sun等。2008), association studies 2 链接到Szgene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息
网络 Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献:31

Section I. Genetics and epigenetics annotation

@EQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID PVALUE QVALUE TSS距离 EQTL类型
RS865199 1 208028592 PLXNA2 ENSG00000076356.6 4.2908E-7 0.01 389073 gtex_brain_ba24

第二节。转录组注释

一般基因表达(GTEX)

无法使用

Devlopment期间的基因表达(BrainCloud)

Footnote:
共有269个时间点秘密策划,n = 38胎儿samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达(brainspan)

Footnote:
SC:亚皮质区域;SM:感觉运动区域;FC:额叶皮层;和TP:颞顶皮层
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。

大脑区域的顶级共表达基因

前10个积极共表达的基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
RBM5 0.94 0.94
PRPF3 0.93 0.93
mettl3 0.93 0.92
RBM6 0.92 0.93
ZNF509 0.92 0.93
hars2 0.92 0.91
ZCCHC8 0.91 0.92
Znf7 0.91 0.92
CCNL1 0.91 0.92
ZNF211 0.91 0.90
前10个负共表达基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
AF347015.31 -0.76 -0.87
AF347015.27 -0.74 -0.85
MT-CO2 -0.74 -0.85
mt-cyb -0.71 -0.82
ifi27 -0.71 -0.82
AF347015.33 -0.71 -0.80
AIFM3 -0.70 -0.73
AF347015.8 -0.70 -0.83
HLA-F -0.70 -0.71
HIGD1B -0.68 -0.81

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0004872 受体活性 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去:0007165 信号转导 IEA -
去:0007275 multicellular organismal development IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去:0005622 细胞内 IEA -
去:0016020 membrane IEA -
GO:0016021 膜不可或缺 IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG轴突指导 129 103 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
Reactome Axon指导 251 188 All SZGR 2.0 genes in this pathway
SEMA3A信号中的Reactome CRMP 14 14 All SZGR 2.0 genes in this pathway
Reactome其他闪光素相互作用 15 14 All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 15 14 All SZGR 2.0 genes in this pathway
Reactome Smaphorin相互作用 68 53 All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 13 9 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向 191 128 All SZGR 2.0 genes in this pathway
HU血管生成DN 37 25 All SZGR 2.0 genes in this pathway
Rashi对电离辐射1的响应1 45 27 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 62 33 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
Kim Myc放大目标DN 97 51 All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN 637 377 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
gotzmann上皮到间充质过渡dn 206 136 All SZGR 2.0 genes in this pathway
Benporath Suz12目标 1038 678 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
与H3K27me3的Benporath ES 1118 744 All SZGR 2.0 genes in this pathway
Benporath PRC2目标 652 441 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞 293 193 All SZGR 2.0 genes in this pathway
Jazaeri乳腺癌BRCA1 vs BRCA2 DN 43 31 All SZGR 2.0 genes in this pathway
Browne HCMV感染24小时 148 96 All SZGR 2.0 genes in this pathway
Bild HRAS致癌特征 261 166 All SZGR 2.0 genes in this pathway
Lee转移和替代剪接 74 51 All SZGR 2.0 genes in this pathway
Martinez RB1靶向DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向DN 591 366 All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 93 40 All SZGR 2.0 genes in this pathway
Boyault肝癌子类G1 UP 113 70 All SZGR 2.0 genes in this pathway
黄成人组织茎模块 721 492 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向 504 321 All SZGR 2.0 genes in this pathway
Bruins通过TP53组A的UVC响应 898 516 All SZGR 2.0 genes in this pathway
ewsr1 fli1融合DN的TORCHIA目标 321 200 All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标 824 528 All SZGR 2.0 genes in this pathway
Rattenbacher由Celf1绑定 467 251 All SZGR 2.0 genes in this pathway
林乳腺干细胞向上 489 314 All SZGR 2.0 genes in this pathway
Durand Stroma S向上 297 194 All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上 1839年 928 All SZGR 2.0 genes in this pathway
NABA ECM有关联 171 89 All SZGR 2.0 genes in this pathway
NABA女性相关 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-101 4940 4946 M8 hsa-miR-101 uacaguacugauaacugaag
miR-137 1174 1181 1A,M8 HSA-MIR-137 uauugcuuaagaauacgcguag
mir-142-5p 352 358 M8 HSA-MIR-142-5P cauaaaguagaaagcacuac
miR-145 4730 4736 1a HSA-MIR-145 guccaguuucccaggaaucccuu
miR-15/16/195/424/497 302 308 M8 HSA-MIR-15Abrain uagcagcacauaugguugug
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain uagcagcacaucaugguuaca
HSA-MIR-195SZ uagcagaaaaauauuggc
hsa-miR-424 Cagcagcaauucauguuuugaa
HSA-MIR-497 cagcagcacacuguguuugu
miR-199 4728 4735 1A,M8 HSA-MIR-199A CCCAGUGUUCAGACUACCUGUUC
HSA-MIR-199B cccaguguuuagacuaucuuc
mir-214 3780 3787 1A,M8 hsa-miR-214brain acagcaggcacagacaggcag
mir-26 1180 1187 1A,M8 HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-30-5p 1164 1171 1A,M8 HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-31 2052 2058 M8 HSA-MIR-31 Aggcaagaugcuggcauagcug
mir-326 92 98 M8 hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
mir-330 305 311 M8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-369-3p 4740 4747 1A,M8 HSA-MIR-369-3P aauauacaugguugaucuuu
miR-374 4741 4747 M8 HSA-MIR-374 uuauaauacaAccugauaagug
miR-378 2105 2111 1a HSA-MIR-378 CUCCUGACUCCAGGUCCUGUGU
mir-410 4948 4955 1A,M8 HSA-MIR-410 aauauaacacagauggcugu