Gene Page:PMCH

Summary?
GeneID 5367
Symbol PMCH
Synonyms MCH|ppMCH
Description pro-melanin concentrating hormone
Reference MIM:176795|HGNC:HGNC:9109|Ensembl:ENSG00000183395|HPRD:01459|Vega:OTTHUMG00000170479
Gene type protein-coding
Map location 12q23.2
Pascal p-value 0.991
Support G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0030354 melanin-concentrating hormone activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007268 synaptic transmission IEA neuron, Synap, Neurotransmitter (GO term level: 6) -
GO:0007218 neuropeptide signaling pathway IEA Neurotransmitter (GO term level: 8) -
GO:0007283 spermatogenesis NAS -
GO:0007165 signal transduction NAS 1572663
GO:0007631 feeding behavior IEA -
GO:0007631 feeding behavior ISS -
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region NAS 8326825

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188 108 All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305 177 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION DN 68 41 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT DN 47 32 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 95 57 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 66 47 All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS UP 50 26 All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN 45 28 All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS DN 120 69 All SZGR 2.0 genes in this pathway
MCCOLLUM GELDANAMYCIN RESISTANCE UP 10 9 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 88 59 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-155 165 171 1A hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG