Gene Page:BRWD1

概括?
基因 54014
象征 BRWD1
Synonyms C21orf107 | DCAF19 | N143 | WDR9
Description 包含1的溴结构域和WD重复域
Reference HGNC: HGNC: 12760|Ensembl:ENSG00000185658|HPRD:11683|Vega:OTTHUMG00000066030
Gene type protein-coding
Map location 21q22.2
Pascal p-value 0.01
度p-value DEG：SANDERS_2014：DS1_P = -0.210：DS1_BETA = 0.001850：DS2_P = 9.29E-02：DS2_BETA = -0.083：DS2_FDR = 2.84E-01
Fetal beta 1.145
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans
元

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
度:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
Expression 元-analysis of gene expression Pvalue: 1.469

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21203420 21 40684731 BRWD1 -0.018 0.46 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2261205 chr5 180626340 BRWD1 54014 0.06 trans
rs750788 chr5 180638894 BRWD1 54014 0.1 trans
RS16958358 chr17 55502410 BRWD1 54014 0.16 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0030528 transcription regulator activity IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
去：0006357 regulation of transcription from RNA polymerase II promoter IEA -
去：0006350 transcription IEA -
GO:0008150 biological_process nd -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 16780588
GO:0005634 nucleus IEA -
GO:0005737 细胞质 IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PARENT MTOR SIGNALING UP 567 375 该途径中的所有SZGR 2.0基因
HORIUCHI WTAP TARGETS UP 306 188 该途径中的所有SZGR 2.0基因
BASAKI YBX1 TARGETS DN 384 230 该途径中的所有SZGR 2.0基因
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS DN 459 276 该途径中的所有SZGR 2.0基因
BIDUS METASTASIS DN 161 93 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS DN 848 527 该途径中的所有SZGR 2.0基因
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 该途径中的所有SZGR 2.0基因
BENPORATH ES 1 379 235 该途径中的所有SZGR 2.0基因
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 该途径中的所有SZGR 2.0基因
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 该途径中的所有SZGR 2.0基因
KUNINGER IGF1 VS PDGFB TARGETS UP 82 51 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性5 482 296 该途径中的所有SZGR 2.0基因
HELLER HDAC TARGETS UP 317 208 该途径中的所有SZGR 2.0基因
DAIRKEE CANCER PRONE RESPONSE BPA 51 35 该途径中的所有SZGR 2.0基因
CCND1和CDK4的Molenaar目标 67 48 该途径中的所有SZGR 2.0基因
Matzuk减数分裂和DNA修复 39 26 该途径中的所有SZGR 2.0基因
PYEON CANCER HEAD AND NECK VS CERVICAL UP 193 95 该途径中的所有SZGR 2.0基因
DELACROIX RAR BOUND ES 462 273 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
mir-122 2315 2321 m8 hsa-miR-122a UGGAGUGUGACAAUGGUGUUUGU
miR-124.1 873 879 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 872 879 1A,m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-125/351 90 96 1A hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain ucccugagacccuuaaccugug
miR-130/301 159 165 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain Cagugcaaugaagggauggau
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-132/212 144 151 1A,m8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain uaacagucuacccaugggg
miR-181 126 132 m8 HSA-MIR-181Abrain aacauucaacgcugucggugagu
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 197 203 1A hsa-miR-182 uuuggcaaugguagaacucaca
miR-186 894 900 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 158 164 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b ugugcaaauccaugcaaaacuga
miR-200bc/429 237 243 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-23 128 134 m8 hsa-miR-23abrain aucacauugccagggauucc
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-26 2550 2556 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ uucaaguaauucaggauagguu
miR-29 2275 2282 1A,m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-30-5p 418 425 1A,m8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-323 128 134 1A HSA-MIR-323brain gcacauuacggucgaccucu
mir-376 112 119 1A,m8 hsa-miR-376a AUCAUAGAGGAAAAUCCACGU
hsa-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-433-3p 139 145 m8 hsa-miR-433brain AUCAUGAUGGGCUCCUCGGUGU
miR-7 834 840 1A hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
mir-96 196 203 1A,m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC